Results 111 to 120 of about 396,285 (245)

Partial or Complete Loss of Norepinephrine Differentially Alters Contextual Fear and Catecholamine Release Dynamics in Hippocampal CA1

Biological Psychiatry Global Open Science
Background: Contextual fear learning is heavily dependent on the hippocampus. Despite evidence that catecholamines contribute to contextual encoding and memory retrieval, the precise temporal dynamics of their release in the hippocampus during behavior ...
Leslie R. Wilson, Nicholas W. Plummer, Irina Y. Evsyukova, Daniela Patino, Casey L. Stewart, Kathleen G. Smith, Kathryn S. Konrad, Sydney A. Fry, Alex L. Deal, Victor W. Kilonzo, Sambit Panda, Natale R. Sciolino, Jesse D. Cushman, Patricia Jensen   +13 more
doaj   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3333-3353, October 2026.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

Pharmacology and Distribution of Norepinephrine Transporters in the Human Locus Coeruleus and Raphe Nuclei

, 1997
The norepinephrine transporter (NET) is a site of action for tricyclic antidepressant drugs and for drugs of abuse such as amphetamine and cocaine. In this study, the binding of [3H]nisoxetine to NETs in the noradrenergic cell group, the locus coeruleus,
Craig A. Stockmeier, Garrick W. Cason, Violetta Klimek, Gregory A. Ordway   +3 more
core   +1 more source

Dexmedetomidine Inhibition of GABA Neurons in the Ventral Tegmental Area Attenuates the Depth of Sedation in Mice

Brain and Behavior, Volume 16, Issue 10, October 2026.
Graphical Abstract ABSTRACT Introduction Dexmedetomidine is a sedative anesthetic with a unique ability to produce an arousable state of sedation. However, the neural mechanisms underlying this arousable sedation remain incompletely understood. Previous studies have implicated dopaminergic neurons in the ventral tegmental area (VTA) in mediating this ...
Jin Rao, Gaolin Qiu, Jiansheng Wang, Yuanhai Li   +3 more
wiley   +1 more source

Trigeminal Nerve Stimulation for Disorders of Consciousness: A Narrative Review of Potential Mechanisms, Clinical Evidence, and Future Perspectives

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Preclinical studies indicate that Trigeminal Nerve Stimulation (TNS) treats Disorders of Consciousness (DoC) by activating neural pathways that promote the release of orexin, dopamine, and norepinephrine. Additionally, TNS modulates cerebral hemodynamics and immunoregulation to enhance consciousness in experimental animals.
Haodong Niu, Yilin Zhang, Nan Wang, Xiaoke Chai, Yiyi Zhai, Zhiyao Zheng, Yangxi Xu, Yitong Jia, Kefei Wan, Sipeng Zhu, Tianqing Cao, Qiheng He, Minghao Liu, Zhuoyang Li, Yichen Wang, Haitao Huang, Juanning Si, Yi Yang, Jizong Zhao   +18 more
wiley   +1 more source

Propofol regulates arousal by enhancing inhibitory synaptic transmission of noradrenergic neurons in the locus coeruleus of adult male mice

Scientific Reports
Locus coeruleus-noradrenergic (LC-NA) neurons have been suggested to be involved in the effects of general anesthetics. However, the contribution of LC-NA neurons during propofol anesthesia remains unknown.
Tatsuya Abe, Miyuki Kurabe, Yuka Nakamura, Mika Sasaki, Yutaka Seino, Kenta Furutani, Masaki Ueno, Hiroshi Baba   +7 more
doaj   +1 more source

Brain‐Wide Connectivity and Topographic Organization of Leptin Receptor Neurons in the Dorsomedial Hypothalamus

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Whole‐brain input–output mapping reveals that DMDLepRb and DMHLepRb neurons share a highly conserved global connectivity architecture yet exhibit local connection biases: DMDLepRb neurons preferentially integrate arousal and defensive signals, whereas DMHLepRb neurons favor viscerosensory and metabolic inputs, uncovering a principle of conserved global
Yaxin Hao, Xiang Zhang, Danyang Zhao, Haixing Zhong, Yongqiang Chen, Heming Li, Minghui Ren, Mengchu Zhu, Fang Yuan   +8 more
wiley   +1 more source

Locus coeruleus

Scholarpedia, 2010
Sébastien Bouret, Susan Sara
openaire   +2 more sources

Impaired Dynamic Cerebral Autoregulation Across the REM Sleep Behavior Disorder Spectrum: Evidence From Isolated REM Sleep Without Atonia to Parkinson's Disease With RBD

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
The progression from isolated REM sleep without atonia (iRSWA) to isolated REM sleep behavior disorder (iRBD) and Parkinson's disease with RBD, accompanied by increasing autonomic dysfunction and REM sleep disruption. Elevated phasic RSWA, reduced REM sleep duration, autonomic dysfunction, and neurotransmitter dysregulation contribute to impaired ...
Yanan Zhang, Ying Piao, Qingqing Sun, Huimin Li, Yaru Wang, Jun Lu, Zhenni Guo, Zan Wang   +7 more
wiley   +1 more source

Raw data for: Optogenetic stimulation of the locus coeruleus enhances appetitive extinction in rats

behavioural data described in: Optogenetic stimulation of the locus coeruleus enhances appetitive extinction in rats appearing in ...
Corbit, Laura
core   +1 more source