Results 111 to 120 of about 380,424 (246)

Partial or Complete Loss of Norepinephrine Differentially Alters Contextual Fear and Catecholamine Release Dynamics in Hippocampal CA1

Biological Psychiatry Global Open Science
Background: Contextual fear learning is heavily dependent on the hippocampus. Despite evidence that catecholamines contribute to contextual encoding and memory retrieval, the precise temporal dynamics of their release in the hippocampus during behavior ...
Leslie R. Wilson, Nicholas W. Plummer, Irina Y. Evsyukova, Daniela Patino, Casey L. Stewart, Kathleen G. Smith, Kathryn S. Konrad, Sydney A. Fry, Alex L. Deal, Victor W. Kilonzo, Sambit Panda, Natale R. Sciolino, Jesse D. Cushman, Patricia Jensen   +13 more
doaj   +1 more source

Bladder distention activates noradrenergic locus coeruleus neurons by an excitatory amino acid mechanism.

, 1992
International audienceThe present study was designed to determine the neurotransmitter(s) involved in activation of noradrenergic locus coeruleus neurons by urinary bladder distention.
Aston-Jones, G., Page, M.E., Valentino, R.J., Akaoka, H.   +3 more
core   +1 more source

Comorbidity Mechanism and Management of Chronic Low Back Pain and Major Depressive Disorder: From Neural Circuit Remodeling to Precision Medicine

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Objective This review systematically elaborates multi‐system interactive mechanisms underlying comorbid chronic low back pain (CLBP) and major depressive disorder (MDD), synthesizes recent advances in diagnosis, treatment, and management, and proposes precision medicine directions to address clinical challenges, including missed diagnosis ...
Lin Faqu, Lin Chenjuan, Xiang Xiangyin, Li Xin   +3 more
wiley   +1 more source

LOCUS COERULEUS NOREPINEPHRINE IN ACTIVE AVOIDANCE AND REWARD SEEKING BEHAVIOR

Cue driven behavior relies on the ability to appropriately respond to stimuli in the environment to obtain resources (food, water, etc.) or avoid threats/danger.
Rodberg, Ellen
core   +1 more source

Effects of Transcutaneous Vagus Nerve Stimulation on Cerebral Perfusion and Cognitive Function Under Simulated High‐Altitude Hypobaric Hypoxia

Brain and Behavior, Volume 16, Issue 9, September 2026.
This graphical abstract illustrates the study design of this research. Participants were divided into tVNS (n = 23) and control (n = 20) groups. Baseline MRI was acquired before chamber entry. Biochemical and cognitive tests were performed at three phases: pre‐chamber, in‐chamber (with tVNS for the intervention group), and post‐exit. Follow‐up MRI were
Xiaojun Yu, Jinhao Lyu, Jiayu Huang, Yuheng Mao, Wenxia Zhou, Jian Hu, Yongqin Xiong, Xiaoxiao Ma, Jianxing Hu, Caohui Duan, Chenran Wang, Xiangbing Bian, Lin Ma, Jianhui Wang, Xin Lou   +14 more
wiley   +1 more source

Neural Circuit Mechanisms of Disorders of Consciousness and Potential Therapeutic Targets of Brain Stimulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review integrates three hierarchical frameworks—ascending reticular activating system (ARAS), mesocircuit hypothesis, and intrinsic connectivity networks (ICNs)—to update the neural mechanisms of disorders of consciousness (DoC). We highlight emerging evidence for glutamatergic ARAS pathways, a bidirectional GPi–GPe mesocircuit regulating ...
Yichen Zhou, Tianqing Cao, Sipeng Zhu, Qiheng He, Yitong Jia, Xiaoke Chai, Nan Wang, Yi Yang   +7 more
wiley   +1 more source

Propofol regulates arousal by enhancing inhibitory synaptic transmission of noradrenergic neurons in the locus coeruleus of adult male mice

Scientific Reports
Locus coeruleus-noradrenergic (LC-NA) neurons have been suggested to be involved in the effects of general anesthetics. However, the contribution of LC-NA neurons during propofol anesthesia remains unknown.
Tatsuya Abe, Miyuki Kurabe, Yuka Nakamura, Mika Sasaki, Yutaka Seino, Kenta Furutani, Masaki Ueno, Hiroshi Baba   +7 more
doaj   +1 more source

Whole‐Brain Monosynaptic Inputs and Outputs of Corticotropin‐Releasing Hormone Neurons of the Paraventricular Nucleus of the Hypothalamus in Male Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Using rabies‐based monosynaptic retrograde tracing and AAV anterograde labeling, this study maps the brain‐wide inputs and outputs of PVN CRH neurons, identifying them as a key hub coordinating stress, autonomic, and behavioral responses. ABSTRACT Objective The paraventricular nucleus of the hypothalamus (PVN) is a central hub integrating ...
Ziteng Yue, Danyang Zhao, Xinxin Chen, Yousheng Zhang, Heng Zhang, Yinchang Wang, Yuhang Liu, Yuxin Yang, Can Geng, Yimeng Song, Xiaoyi Wang, Sheng Wang   +11 more
wiley   +1 more source

Locus coeruleus

Scholarpedia, 2010
Sébastien Bouret, Susan Sara
openaire   +2 more sources

Advances in Targeting Central Cholinergic Dysfunction for Neurodegenerative Diseases: From Pharmacotherapy to Neuromodulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review charts the evolution of cholinergic therapies for neurodegenerative diseases—from classical acetylcholinesterase inhibitors (AChEIs) providing symptomatic relief to precision multi‐target drugs and neuromodulation (VNS, DBS, NIBS) that restore dysfunctional circuits. Emerging gene therapy, cell regeneration, and advanced cholinergic imaging
Lei Lei, Xiaoyu Hu, Ruida Lu, Jian‐jun Yang, Qingsheng Meng   +4 more
wiley   +1 more source