Results 111 to 120 of about 52,640 (225)

Temperature Dependence of Paramagnetic Species in the Human Brain Tissue: An X‐Band EPR Study

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 3031-3043, May 2026.
ABSTRACT Purpose Paramagnetic ions are distributed throughout the human brain. The increased accumulation of these metals, such as iron and copper, can induce cellular death and the development of neurological diseases. Electron Paramagnetic Resonance (EPR) is a spectroscopic technique capable of detecting these ions in a given biological sample ...
André Avanzine, José Henrique Monteiro de Azevedo, Martina Huber, Fábio Seiji Otsuka, Maria Concepción García Otaduy, Roberta Diehl Rodriguez, Carlos Ernesto Garrido Salmon   +6 more
wiley   +1 more source

Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity

eLife
Impairments of locus coeruleus (LC) are implicated in anxiety/depression and Alzheimer’s disease (AD). Increases in cytosolic noradrenaline (NA) concentration and monoamine oxidase A (MAO-A) activity initiate the LC impairment through production of NA ...
Hiroki Toyoda, Doyun Kim, Byeong Geon Koh, Tomomi Sano, Takashi Kanematsu, Seog Bae Oh, Youngnam Kang   +6 more
doaj   +1 more source

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, Volume 183, Issue 9, Page 2099-2122, May 2026.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Partial or Complete Loss of Norepinephrine Differentially Alters Contextual Fear and Catecholamine Release Dynamics in Hippocampal CA1

Biological Psychiatry Global Open Science
Background: Contextual fear learning is heavily dependent on the hippocampus. Despite evidence that catecholamines contribute to contextual encoding and memory retrieval, the precise temporal dynamics of their release in the hippocampus during behavior ...
Leslie R. Wilson, Nicholas W. Plummer, Irina Y. Evsyukova, Daniela Patino, Casey L. Stewart, Kathleen G. Smith, Kathryn S. Konrad, Sydney A. Fry, Alex L. Deal, Victor W. Kilonzo, Sambit Panda, Natale R. Sciolino, Jesse D. Cushman, Patricia Jensen   +13 more
doaj   +1 more source

The Correlation between Sleep and Creativity [PDF]

, 2010
Fredrich August von Kekule, a famous German chemist, was attempting to determine the shape of the benzene molecule, which was known to have six carbon atoms.
Debora Aricò, John Williamson, Kenneth Heilman, Pasquale Montagna, Paul Foster, Raffaele Ferri, Valeria Drago   +6 more
core   +1 more source

Sleep Alters the Velocity of Physiological Brain Pulsations in Humans

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Sleep alters I/CSF oscillatory flow, driven by increased respiratory (29%) and vasomotor pulsation (21%) velocities, while cardiovascular pulsations decreased by (22%). Velocity is quantified using optical flow analysis of MREG data. Spectral power increases alongside these pulsations (spatial correlation, r = 0.35 and r = 0.39, respectively ...
Ahmed Elabasy, Heta Helakari, Tommi Väyrynen, Zalán Rajna, Niko Huotari, Lauri Raitamaa, Ville Isokoski, Matti Järvelä, Mika Kaakinen, Johanna Piispala, Mika Kallio, Vesa Korhonen, Tapio Seppänen, Vesa Kiviniemi   +13 more
wiley   +1 more source

Locus coeruleus-CA1 projections are involved in chronic depressive stress-induced hippocampal vulnerability to transient global ischaemia

Nature Communications, 2019
Depression and transient ischaemic attacks are tightly regulated but the neural circuits underlying depression-modulated ischaemic injury are not known.
Qian Zhang, Dian Xing Hu, Feng He, Chun Yang Li, Guang Jian Qi, Hong Wei Cai, Tong Xia Li, Jie Ming, Pei Zhang, Xiao Qian Chen, Bo Tian   +10 more
doaj   +1 more source

Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety

Advanced Science, Volume 13, Issue 24, 27 April 2026.
This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi, Xiaoyi Wang, Huichun Luo, Ziteng Yue, Tianjiao Deng, Yuhang Liu, Xinxin Chen, Jianxu Zhao, Luo Shi, Ning Ma, Lingyan Mao, Jing Ding, Jiwen Xu, Ti‐Fei Yuan, Sheng Wang, Fang Yuan   +15 more
wiley   +1 more source

Effect of sensory deprivation and locus coeruleus phasic electrical stimulation following the deflection of adjacent whisker on response properties of principal whisker related-neurons in layer IV of rat barrel cortex [PDF]

Background: Barrel cortex of rodents is responsible for sensory information processing via facial whiskers. Locus coeruleus (LC), main source of cortical norepinephrine (NE), influences tactile sensory processing.
آفرینش, محمدرضا, سیاه پشت خاچکی, علی, شمسی زاده, علی, شیبانی, وحید, شیخکانلوی میلان, حمید   +4 more
core  

Prolonged morning wake transitions associated with amyloid beta burden: A cross‐sectional pilot study

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Sleep quality critically influences amyloid beta (Aβ) clearance, yet the specific role of morning wake transition duration remains unexplored. METHODS This hypothesis‐driven secondary analysis examined 97 cognitively unimpaired older adults (mean age ± SD: 74.4 ± 5.8 years) who underwent 14‐day actigraphy and 18F‐florbetapir ...
Georg von Fingerhut, Keitaro Makino, Yosuke Osuka, Kengo Ito, Takashi Kato, Shosuke Satake, Hiroyuki Shimada   +6 more
wiley   +1 more source