Results 91 to 100 of about 411,191 (267)
Movement Disorders Clinical Practice, EarlyView.Abstract Background Parkinson's disease (PD) is clinically heterogeneous, with variable progression rates that complicate clinical trial design. The data‐driven diffuse malignant (DM), intermediate (IM), and mild‐motor predominant (MMP) subtyping model has prognostic value but lacks disease duration–specific thresholds for prospective use in disease ...
Ahmed Negida +4 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo +10 more
wiley +1 more source
Natural Locus Coeruleus Dynamics During Feeding [PDF]
Data and code for the manuscript "Natural Locus Coeruleus Dynamics During Feeding" by Sciolino et.
SCIOLINO, NATALE
core +1 more source
Functional LOCUS COERULEUS IMAGING [PDF]
Data and scripts for the publication "Functional LOCUS COERULEUS IMAGING to investigate an ageing noradrenergic system"
Mareike Ludwig
core +2 more sources
Cell Reports, 2018 Summary: How general anesthesia causes loss of consciousness has been a mystery for decades. It is generally thought that arousal-related brain nuclei, including the locus coeruleus (LC), are involved.
Wen-jie Du +9 more
doaj +1 more source
medRxiv, 2020 Cognitive decline is a common feature of Parkinson's disease, and many of these cognitive deficits fail to respond to dopaminergic therapy. Therefore, targeting other neuromodulatory systems represents an important therapeutic strategy.
C. O’Callaghan +14 more
semanticscholar +1 more source
Heterogenous Neuropathology in a Pedigree with RAB39B‐Related Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background In 2015, we reported a family with Parkinson's disease resulting from the RAB39B p.G192R (c.574G>A) variant. Since then, two affected brothers from the family have undergone autopsy. Objectives To characterize neuropathological findings, assess intracellular distribution of RAB39B protein, and examine the effect of p.G192R on α ...
Caitlin Latimer +15 more
wiley +1 more source
Lesions of the locus coeruleus system aggravate ischemic damage in the rat brain [PDF]
, 1985 The possibility that the noradrenergic locus coeruleus system influences brain damage following ischemia was explored in rats. Bilateral lesions of the locus coeruleus projections to the forebrain aggravated the neuronal necrosis in the hippocampal CAI ...
Lindvall, Olle, +3 more
core +3 more sources
Increased opioid dependence in a mouse model of panic disorder
Frontiers in Behavioral Neuroscience, 2010 Panic disorder is a highly prevalent neuropsychiatric disorder that shows co-occurrence with substance abuse. Here, we demonstrate that TrkC, the high affinity receptor for neurotrophin-3, is a key molecule involved in panic disorder and opiate ...
Xavier Gallego +8 more
doaj +1 more source
A role for locus coeruleus in Parkinson tremor [PDF]
Frontiers in Human Neuroscience, 2012 We analyzed rest tremor, one of the etiologically most elusive hallmarks of Parkinson disease (PD), in 12 consecutive PD patients during a specific task activating the locus coeruleus (LC) to investigate a putative role of noradrenaline (NA) in tremor generation and suppression.
Ioannis Ugo eIsaias +9 more
openaire +4 more sources