Results 61 to 70 of about 31,294 (247)

Effectiveness and safety of implantable vagus nerve stimulation in people with primary generalized tonic–clonic seizures

Epilepsia Open, EarlyView.
The impact of prompt diagnosis and treatment, and early predictors of outcome severity in this cohort. Abstract Objective Most therapies for drug‐resistant epilepsy (DRE) focus on focal‐onset seizures, the most common seizure types. Studying primary generalized tonic–clonic seizures (PGTCS) is more challenging due to diagnostic and recruitment ...
Katherine Eggleston, Justine Curley, Ryan Verner, Maxine Dibue, Charles Gordon, Gaia Giannicola, Kathryn Nichol   +6 more
wiley   +1 more source

Dopaminergic novelty detection and theta oscillations: Virtual reality‐based adaptive interventions for cognitive enhancement in aging

Ibrain, EarlyView.
Aging‐related cognitive decline is associated with reduced dopaminergic signaling and disrupted theta oscillations, which together impair novelty detection and memory formation. This review shows how VR environments can be used to deliver adaptive, novelty‐rich stimuli that engage dopaminergic circuits and entrain theta rhythms, thereby enhancing ...
Abraham Olufemi Asuku, Ayodeji Johnson Ajibare   +1 more
wiley   +1 more source

Adrenergic signalling to astrocytes in anterior cingulate cortex contributes to pain-related aversive memory in rats

Communications Biology, 2023
Chemogenetic and optogenetic profiling in a rat model of acute pain-related unpleasantness suggests that colorectal distention-induced place aversion is mediated by locus coeruleus noradrenergic signalling to astrocytes in anterior cingulate cortex.
Zafar Iqbal, Zhuogui Lei, Aruna S. Ramkrishnan, Shu Liu, Mahadi Hasan, Mastura Akter, Yuk Yan Lam, Ying Li   +7 more
doaj   +1 more source

Microinjection of vasopressin into the locus coeruleus of conscious rats

, 1984
To determine whether vasopressin plays a role in central neural control of cardiovascular function by acting on the locus coeruleus we monitored arterial pressure and heart rate responses to graded injections of vasopressin (1-30 ng, 0.1-0.3 microliter ...
Berecek, K. H., K. G. Hofbauer, H. R. Olpe, R. S. Jones, Jones, R. S., Hofbauer, K. G., K. H. Berecek, Olpe, H. R.   +7 more
core   +1 more source

Fingerprinting heterocellular β-adrenoceptor functional expression in the brain using agonist activity profiles

Frontiers in Molecular Biosciences, 2023
Noradrenergic projections from the brainstem locus coeruleus drive arousal, attentiveness, mood, and memory, but specific adrenoceptor (AR) function across the varied brain cell types has not been extensively characterized, especially with agonists. This
Rachel A. Matt, Frederick G. Westhorpe, Rosemary F. Romuar, Payal Rana, Joel R. Gever, Anthony P. Ford   +5 more
doaj   +1 more source

Mapping Neurodegenerative Changes in Clinically Uncertain Parkinsonian Syndrome Patients Using Fast MR Spin TomogrAphy in Time‐Domain (MR‐STAT) Relaxometry at 3T

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background MR Spin TomogrAphy in Time‐domain (MR‐STAT) enables accelerated multiparametric relaxometry (T1/T2). Previous relaxometry studies predominantly compared Parkinson's disease patients with healthy controls (HC). The potential of relaxometry to distinguish neurodegenerative from non‐neurodegenerative parkinsonism in clinically ...
Martin B. Schilder, Elon D. Wallert, Stefano Mandija, Oscar van der Heide, Hongyan Liu, Miha Fuderer, Edwin Versteeg, Jan Booij, Rob M. A. de Bie, Martijn Beudel, Henk W. Berendse, Tom van Mierlo, Jeroen Blankevoort, Cornelis A. T. van den Berg, Elsmarieke van de Giessen, Alessandro Sbrizzi   +15 more
wiley   +1 more source

In vivo mapping of the human locus coeruleus [PDF]

NeuroImage, 2009
The locus coeruleus (LC) is a brainstem structure that has widespread cortical and sub-cortical projections to modulate states of attention. Our understanding of the LC's role in both normal attention and clinical populations affected by disrupted attention would be advanced by having in vivo functional and structural markers of the human LC.
Noam I. Keren, Carl Lozar, Kelly C. Harris, Paul S. Morgan, Mark A. Eckert   +4 more
openaire   +2 more sources

Exocrine Gland Dysfunction in Parkinson's Disease: Pathophysiology, Clinical Manifestations, and Therapeutic Perspectives—A Narrative Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz, Marina Farah, Laura Silveira‐Moriyama   +2 more
wiley   +1 more source

The effects of footshock and immobilization stress on tyrosine hydroxylase phosphorylation in the rat locus coeruleus and adrenal gland

, 2011
Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is regulated acutely by protein phosphorylation. No studies have systematically investigated the time course of TH phosphorylation in vivo in response to different ...
Bobrovskaya, L., L. Guan, Guan, L., L.K. Ong, P.W. Dickson, Dickson, P. W., B. Stutz, Dunkley, P., P.R. Dunkley, Dunkley, P. R., Stutz, B., Ong, L. K., L. Bobrovskaya, Dickson, P., Ong, L.K.   +14 more
core   +1 more source

Organization of the Locus Coeruleus-Norepinephrine System

, 2015
The release of the neurotransmitter norepinephrine throughout the mammalian brain is important for modulating attention, arousal, and cognition during many behaviors.
Luo, Liqun, Schwarz, Lindsay A.
core   +1 more source