Results 61 to 70 of about 396,285 (245)

The Locus Coeruleus in Chronic Pain

International Journal of Molecular Sciences
Pain perception is the consequence of a complex interplay between activation and inhibition. Noradrenergic pain modulation inhibits nociceptive transmission and pain perception. The main source of norepinephrine (NE) in the central nervous system is the Locus Coeruleus (LC), a small but complex cluster of cells in the pons.
Jorge Castejón España, Anusha Yasoda-Mohan, Sven Vanneste   +2 more
openaire   +2 more sources

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid, Piyush Padhi, Mahsa Gifani, John S. Beck, Jacob P. Thomas, Gargi Khadse, Catherine Kudela, Gregory J. Phillips, Anumantha G. Kanthasamy, Scott E. Counts   +9 more
wiley   +1 more source

The Locus Coeruleus Modulates Intravenous General Anesthesia of Zebrafish via a Cooperative Mechanism

Cell Reports, 2018
Summary: How general anesthesia causes loss of consciousness has been a mystery for decades. It is generally thought that arousal-related brain nuclei, including the locus coeruleus (LC), are involved.
Wen-jie Du, Rong-wei Zhang, Jia Li, Bai-bing Zhang, Xiao-lan Peng, Song Cao, Jie Yuan, Cheng-dong Yuan, Tian Yu, Jiu-lin Du   +9 more
doaj   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Increased opioid dependence in a mouse model of panic disorder

Frontiers in Behavioral Neuroscience, 2010
Panic disorder is a highly prevalent neuropsychiatric disorder that shows co-occurrence with substance abuse. Here, we demonstrate that TrkC, the high affinity receptor for neurotrophin-3, is a key molecule involved in panic disorder and opiate ...
Xavier Gallego, Patricia Murtra, Patricia Murtra, Teresa Zamalloa, Josep Maria Canals, Joseba Pineda, Alejandro Amador-Arjona, Rafael Maldonado, Mara Dierssen   +8 more
doaj   +1 more source

Locus coeruleus stimulation modulates olfactory bulb evoked potentials [PDF]

, 1987
Field-evoked potentials from the main olfactory bulb in response to stimulation of the olfactory nerve and lateral olfactory tract were measured without and with conditioning stimulation of the locus coeruleus noradrenergic system.
Almli, C. Robert, Pérez, Hernán, Hernández, Alejandro   +2 more
core   +1 more source

Neuropsychiatric‐Led Presentation of Late‐Onset Parkin‐Related Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Sarah Fullam, Shane Lyons, Martha Finnegan, Richard Walsh, Sean O'Dowd   +4 more
wiley   +1 more source

Novel targets in headache: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra, Peter J. Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman   +5 more
wiley   +1 more source

Functional LOCUS COERULEUS IMAGING

Data and scripts for the publication "Functional LOCUS COERULEUS IMAGING to investigate an ageing noradrenergic system"
Mareike Ludwig
core   +2 more sources

Double‐blind, sham‐controlled, trial of rhythmic 10 Hz median nerve stimulation for the reduction of tics in Tourette syndrome: Analyses of 3‐month follow‐up data for those receiving active stimulation

Journal of Neuropsychology, EarlyView.
Abstract Tourette syndrome [TS] is a neurological disorder of childhood onset characterised by the occurrence of tics: repetitive, purposeless movements or vocalisations. Effective treatment for tic disorders is an area of considerable unmet clinical need.
Stephen R. Jackson, Barbara Morera Maiquez, Georgina M. Jackson   +2 more
wiley   +1 more source