Results 41 to 50 of about 411,191 (267)

Locus Coeruleus Shows a Spatial Pattern of Structural Disintegration in Parkinson's Disease

Movement Disorders, 2022
Parkinson's disease (PD) causes a loss of neuromelanin‐positive, noradrenergic neurons in the locus coeruleus (LC), which has been implicated in nonmotor dysfunction.
Christopher F. Madelung, David Meder, S. Fuglsang, M. M. Marques, V. Boer, Kristoffer H. Madsen, E. Petersen, A. Hejl, A. Løkkegaard, H. Siebner   +9 more
semanticscholar   +1 more source

A Locus Coeruleus- dorsal CA1 dopaminergic circuit modulates memory linking

bioRxiv, 2021
Individual memories are often linked so that the recall of one triggers the recall of another. For example, contextual memories acquired close in time can be linked, and this is known to depend on temporary increase in excitability that drive the overlap
Ananya Chowdhury, A. Luchetti, Giselle Fernandes, Daniel Almeida Filho, George Kastellakis, Alexandra Tzilivaki, Erica M. Ramirez, Mary Y Tran, Panayiota Poirazi, Alcino J. Silva   +9 more
semanticscholar   +1 more source

A possible role of the locus coeruleus in complex regional pain syndrome [PDF]

, 2012
Heightened sensitivity to painful stimulation commonly spreads from the affected limb to the ipsilateral forehead in patients with complex regional pain syndrome (CRPS).
Peter D Drummond, Drummond, P.D., Peter D. Drummond   +2 more
core   +2 more sources

The locus coeruleus mediates behavioral flexibility

bioRxiv, 2022
Behavioral flexibility refers to the ability to adjust behavioral strategies in response to changing environmental contingencies. A major hypothesis in the field posits that the activity of neurons in the locus coeruleus (LC) plays an important role in ...
Jim McBurney-Lin, Hongdian Yang
semanticscholar   +1 more source

Different Patterns of Locus Coeruleus MRI Alteration in Alzheimer’s and Dementia with Lewy Bodies [PDF]

, 2023
Background: The integrity of Locus Coeruleus can be evaluated in vivo using specific Magnetic Resonance Imaging sequences. While this nucleus has been shown to be degenerated both in post-mortem and in vivo studies in Alzheimer’s Disease, for other ...
Fornai F., Cademartiri F., Ceravolo R., Baldacci F., Tognoni G., Palermo G., Bastiani L., Tommasini L., Giorgi F. S., Gesi M., Galgani A., Vergallo A., Lombardo F., Martini N., Bellini G., Frosini D., Pavese N.   +16 more
core   +1 more source

Localisation of NG2 immunoreactive neuroglia cells in the rat locus coeruleus and their plasticity in response to stress [PDF]

, 2014
The locus coeruleus (LC) nucleus modulates adaptive behavioural responses to stress and dysregulation of LC neuronal activity is implicated in stress-induced mental illnesses.
Metzger, Friedrich, Friedrich Metzger, Metzger, F, Seifi, Mohsen, Mohsen eSeifi, Johannes J. van der Want, Corteen, Nicole L, Jerome D Swinny, van der Want, Johannes J, Corteen, Nicole L., Seifi, M, Swinny, Jerome D, Corteen, NL, Johannes Jacobus Van Der Want, Nicole L. Corteen, Swinny, Jerome D., Swinny, JD, van der Want, Johannes J., van der Want, Johannes, Nicole Louise Corteen, Mohsen Seifi, Jerome D. Swinny, Friedrich eMetzger   +22 more
core   +1 more source

A Reciprocal Relationship Between Bottom-up Trace Strength and the Attentional Blink Bottleneck: Relating the LC-NE and ST2 Models [PDF]

, 2008
There is considerable current interest in neural modelling of the attentional blink phenomenon. Two prominent models of this task are the Simultaneous Type Serial Token (ST2) model and the Locus Coeruleus Norepinephrine (LC-NE) model. The former of these
Craston, Patrick, Chennu, Srivas, Wyble, Brad, Bowman, Howard   +3 more
core   +1 more source

MRI‐assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction

Alzheimer's & Dementia, 2021
The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep–wake cycle, modulating cognitive function, and AD progression.
J. Elman, O. Puckett, A. Beck, C. Fennema-Notestine, Latonya K. Cross, A. Dale, G. Eglit, L. Eyler, N. Gillespie, E. Granholm, D. Gustavson, D. Hagler, S. Hatton, R. Hauger, A. Jak, M. Logue, L. McEvoy, R. McKenzie, M. Neale, M. Panizzon, C. Reynolds, Mark E. Sanderson-Cimino, R. Toomey, X. Tu, Nathan Whitsel, McKenna E. Williams, H. Xian, Melinda Lyons, C. Franz, W. Kremen   +29 more
semanticscholar   +1 more source

Tuning arousal with optogenetic modulation of locus coeruleus neurons. [PDF]

, 2010
Neural activity in the noradrenergic locus coeruleus correlates with periods of wakefulness and arousal. However, it is unclear whether tonic or phasic activity in these neurons is necessary or sufficient to induce transitions between behavioral states ...
de Lecea, Luis, Karl Deisseroth, Carter, Matthew E, Deisseroth, Karl, Antoine Adamantidis, Seiji Nishino, Nguyen, Hieu, Luis de Lecea, Ofer Yizhar, Hieu Nguyen, Matthew E Carter, Sachiko Chikahisa, Adamantidis, Antoine Roger, Yizhar, Ofer, Nishino, Seiji, Chikahisa, Sachiko   +15 more
core   +1 more source

Associations between locus coeruleus integrity and diagnosis, age, and cognitive performance in older adults with and without late-life depression: An exploratory study

NeuroImage: Clinical, 2022
Highlights • Semi-automated segmentation can discern plausible locus coeruleus structure in vivo.• Locus coeruleus structure appears to vary along its rostrocaudal extent.• Individuals with late-life depression show intact locus coeruleus integrity ...
Navona Calarco, C. Cassidy, B. Selby, Colin Hawco, A. Voineskos, B. Diniz, Yuliya S. Nikolova   +6 more
semanticscholar   +1 more source