Results 41 to 50 of about 396,285 (245)
Molecular Pain, 2017 N-acetylaspartylglutamate (NAAG) is the third most prevalent and widely distributed neurotransmitter in the mammalian nervous system. NAAG activates a group II metabotropic glutamate receptor (mGluR3) and is inactivated by an extracellular enzyme ...
Takahiro Nonaka +6 more
doaj +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Parkinson's disease (PD) is clinically heterogeneous, with variable progression rates that complicate clinical trial design. The data‐driven diffuse malignant (DM), intermediate (IM), and mild‐motor predominant (MMP) subtyping model has prognostic value but lacks disease duration–specific thresholds for prospective use in disease ...
Ahmed Negida +4 more
wiley +1 more source
Biology, 2022 Alzheimer’s disease (AD), which is characterized by extracellular accumulation of amyloid-beta peptide and intracellular aggregation of hyperphosphorylated tau, is the most common form of dementia.
Dilek Mercan, Michael Thomas Heneka
doaj +1 more source
Locus coeruleus contrast and diffusivity metrics differentially relate to age and memory performance
Scientific ReportsNeurocognitive aging researchers are increasingly focused on the locus coeruleus, a neuromodulatory brainstem structure that degrades with age. With this rapid growth, the field will benefit from consensus regarding which magnetic resonance imaging (MRI)
Ilana J. Bennett +5 more
doaj +1 more source
Illuminating the locus coeruleus: control of posture and arousal [PDF]
, 2010 Optogenetic stimulation of the locus coeruleus noradrenergic neurons can increase wakefulness, and high-frequency stimulation decreases noradrenaline levels and produces loss of muscle tone similar to that seen in ...
Siegel, Jerome M +3 more
core +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Parkinson's disease (PD) and multiple system atrophy (MSA) are α‐synucleinopathies with overlapping autonomic and sleep dysfunction, but distinct trajectories. Objectives This study compared sleep and autonomic profiles in PD and MSA and elucidated disease‐specific associations using structural equation modeling (SEM).
Bora Jin +5 more
wiley +1 more source
Selective WGA uptake in the hippocampus from the locus coeruleus of DBH-WGA transgenic mice
Frontiers in Behavioral Neuroscience, 2012 We generated transgenic mice in which a transsynaptic tracer, wheat germ agglutinin (WGA), was specifically expressed in the locus coeruleus neurons under the control of the dopamine-β-hydroxylase gene promoter. WGA protein was produced in more than 95%
Susan G eWalling +4 more
doaj +1 more source
The Locus Coeruleus Noradrenaline System in Delirium
Frontiers in Aging Neuroscience, 2021 Delirium is a brain state involving severe brain dysfunction affecting cognitive and attentional capacities. Our opinion statement review aims to elucidate the relationship between abnormal arousal and locus coeruleus (LC) activity in cognitive ...
Niels Hansen, Alina Isabel Rediske
doaj +1 more source
APα restores the number of TH-IR cells in locus coeruleus of MPTP-lesioned mice.
, 2012 Locus coeruleus is a brain structure where the majority of the neurons containing NE. A. Representative images of TH-IR cells in locus coeruleus. B. The numbers of TH-IR cells. C. The number of BrdU-IR cells.
Samuel O. Adeosun (115355) +17 more
core +1 more source
In vivo mapping of the human locus coeruleus [PDF]
NeuroImage, 2009 The locus coeruleus (LC) is a brainstem structure that has widespread cortical and sub-cortical projections to modulate states of attention. Our understanding of the LC's role in both normal attention and clinical populations affected by disrupted attention would be advanced by having in vivo functional and structural markers of the human LC.
Noam I. Keren +4 more
openaire +2 more sources