Impact of early locus coeruleus lesions in the TgF344 Alzheimer's disease rat model. [PDF]
Alzheimers DementAbstract INTRODUCTION In murine models of Alzheimer's disease (AD), lesioning the locus coeruleus–norepinephrine (LC‐NE) system with DSP‐4 exacerbates AD‐like neuropathology and cognitive impairment. However, the impact of LC lesions during prodromal stages is poorly characterized. METHODS TgF344‐AD and wild‐type rats received monthly injections of DSP‐
Marriott AE +6 more
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Altered brainstem responses to modafinil in schizophrenia: implications for adjunctive treatment of cognition. [PDF]
, 2018 Candidate pro-cognitive drugs for schizophrenia targeting several neurochemical systems have consistently failed to demonstrate robust efficacy. It remains untested whether concurrent antipsychotic medications exert pharmacodynamic interactions that ...
Carter, Cameron S +3 more
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Visual and Electrosensory Circuits of the Diencephalon in Mormyrids [PDF]
, 1990 Mormyrids are one of two groups of teleost fishes known to have evolved electroreception, and the concomitant neuroanatomical changes have confounded the interpretation of many of their brain areas in a comparative context, e.g., the diencephalon, where ...
Adams +71 more
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Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling. [PDF]
, 2015 Although PI3Kγ has been extensively investigated in inflammatory and cardiovascular diseases, the exploration of its functions in the brain is just at dawning.
Alessandra Ghigo +10 more
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Locus Coeruleus in Non-Mammalian Vertebrates
Brain Sciences, 2022 The locus coeruleus (LC) is a vertebrate-specific nucleus and the primary source of norepinephrine (NE) in the brain. This nucleus has conserved properties across species: highly homogeneous cell types, a small number of cells but extensive axonal ...
Sijia Wang, Zhirong Wang, Yu Mu
doaj +1 more source
Locus coeruleus complex of the family Delphinidae [PDF]
, 2018 The locus coeruleus (LC) is the largest catecholaminergic nucleus and extensively projects to widespread areas of the brain and spinal cord. The LC is the largest source of noradrenaline in the brain.
Arbelo, Manuel +6 more
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Quantifying the contrast of the human locus coeruleus in vivo at 7 Tesla MRI.
PLoS ONE, 2019 The locus coeruleus is a small brainstem nucleus which contains neuromelanin cells and is involved in a number of cognitive functions such as attention, arousal and stress, as well as several neurological and psychiatric disorders.
Klodiana-Daphne Tona +3 more
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Synaptic interactions between perifornical lateral hypothalamic area, locus coeruleus nucleus and the oral pontine reticular nucleus are implicated in the stage succession during sleep-wakefulness cycle [PDF]
, 2013 This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permissionThe perifornical area in the posterior lateral hypothalamus (PeFLH) has been implicated in several physiological functions ...
Garzón, Miguel +3 more
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Modulation of physiological reflexes by pain: role of the locus coeruleus
Frontiers in Integrative Neuroscience, 2012 The locus coeruleus is activated by noxious stimuli, and this activation leads to inhibition of perceived pain. As two physiological reflexes, the acoustic startle reflex and the pupillary light reflex, are sensitive to noxious stimuli, this sensitivity,
Elemer eSzabadi
doaj +1 more source
The influence of the noradrenergic system on optimal control of neural plasticity [PDF]
, 2013 Decision making under uncertainty is challenging for any autonomous agent. The challenge increases when the environment’s stochastic properties change over time, i.e., when the environment is volatile.
Seurinck, Ruth +3 more
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