Locus Coeruleus Optogenetic Modulation: Lessons Learned from Temporal Patterns [PDF]
Brain Sciences, 2021 After reviewing seminal studies using optogenetics to interrogate the functional role of the locus coeruleus in behavior, we conclude that differences in firing rates and firing patterns of locus coeruleus neurons contribute to locus coeruleus nucleus ...
Carolyn W. Harley, Qi Yuan
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Pain and depression comorbidity causes asymmetric plasticity in the locus coeruleus neurons [PDF]
Brain : a journal of neurology, 2021 There is strong comorbidity between chronic pain and depression, although the neural circuits and mechanisms underlying this association remain unclear.
M. Llorca-Torralba +10 more
semanticscholar +3 more sources
Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson's disease. [PDF]
Brain : a journal of neurology, 2021 Previous studies have reported substantial involvement of the noradrenergic system in Parkinson's disease. Neuromelanin-sensitive MRI sequences and PET tracers have become available to visualize the cell bodies in the locus coeruleus and the density of ...
Christopher E. J. Doppler +16 more
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Locus Coeruleus magnetic resonance imaging in cognitively intact elderly subjects [PDF]
Brain Imaging and Behavior, 2021 The locus coeruleus is the main noradrenergic nucleus of the brain and is often affected in neurodegenerative diseases. Recently, magnetic resonance imaging with specific T1-weighted sequences for neuromelanin has been used to evaluate locus coeruleus ...
F. Giorgi +15 more
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Quantifying the contrast of the human locus coeruleus in vivo at 7 Tesla MRI. [PDF]
PLoS ONE, 2019 The locus coeruleus is a small brainstem nucleus which contains neuromelanin cells and is involved in a number of cognitive functions such as attention, arousal and stress, as well as several neurological and psychiatric disorders.
Klodiana-Daphne Tona +3 more
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Locus coeruleus features are linked to vagus nerve stimulation response in drug-resistant epilepsy [PDF]
Frontiers in NeuroscienceThe locus coeruleus–norepinephrine system is thought to be involved in the clinical effects of vagus nerve stimulation. This system is known to prevent seizure development and induce long-term plastic changes, particularly with the release of ...
Alexandre Berger +20 more
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The Longevity of Hippocampus-Dependent Memory Is Orchestrated by the Locus Coeruleus-Noradrenergic System [PDF]
Neural Plasticity, 2017 The locus coeruleus is connected to the dorsal hippocampus via strong fiber projections. It becomes activated after arousal and novelty, whereupon noradrenaline is released in the hippocampus.
Niels Hansen
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Modulation of physiological reflexes by pain: role of the locus coeruleus [PDF]
Frontiers in Integrative Neuroscience, 2012 The locus coeruleus is activated by noxious stimuli, and this activation leads to inhibition of perceived pain. As two physiological reflexes, the acoustic startle reflex and the pupillary light reflex, are sensitive to noxious stimuli, this sensitivity,
Elemer eSzabadi
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Locus coeruleus and dopaminergic consolidation of everyday memory [PDF]
Nature, 2016 The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect ...
T. Takeuchi +10 more
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Locus coeruleus contrast and diffusivity metrics differentially relate to age and memory performance [PDF]
Scientific ReportsNeurocognitive aging researchers are increasingly focused on the locus coeruleus, a neuromodulatory brainstem structure that degrades with age. With this rapid growth, the field will benefit from consensus regarding which magnetic resonance imaging (MRI)
Ilana J. Bennett +5 more
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