Results 41 to 50 of about 138,491 (253)

The role of noradrenaline in regulating the interaction between CD14⁺ monocytes and CD4⁺ T cells in multiple sclerosis

Неврология, нейропсихиатрия, психосоматика
Multiple sclerosis (MS) is an autoimmune demyelinating and neurodegenerative disease of the central nervous system (CNS) that affects young people. It has been established that CD14+ monocytes and T-helpers (CD4+ T cells) play an important role in both ...
D. V. Nikolaeva, R. R. Zhetishev, A. V. Lopatina, A. A. Sviridova, D. D. Esipova, N. E. Murugina, V. V. Murugin, A. N. Boyko, M. V. Melnikov   +8 more
doaj   +1 more source

Episodic memory: neurological and neuromediator mechanisms

Анналы клинической и экспериментальной неврологии, 2017
Significant advances in understanding of neurological and neuromediatormechanisms of memory along with the causes ofmemory decline in aging were achieved recently.
A. G. Polunina, E. A. Bryun
doaj   +1 more source

Role of the End-Point Mediators of Sympathoadrenal and Sympathoneural Stress Axes in the Pathogenesis of Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

Frontiers in Endocrinology, 2020
The role of stress effector systems in the initiation and progression of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), the most commonly used experimental model of MS, has strongly been suggested. To corroborate this notion,
Ivan Pilipović, Zorica Stojić-Vukanić, Ivana Prijić, Gordana Leposavić   +3 more
doaj   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

Limited Agreement Between Perceptual and Physiological Heat Strain at Initial Stay Times for Continuous Work in the Heat Before Heat Alleviation Controls

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Introduction Accurate assessment of heat strain at initial stay time (IST; core temperature 38.0°C or Δ1.0°C above resting), when heat mitigation decisions are required, is critical for managing occupational heat exposure. We evaluated the relationship and agreement between physiological (Physiological Strain Index [PSI] and adaptive PSI [aPSI]
Gil Bourgois, Kristina‐Marie T. Janetos, Fergus K. O'Connor, Leonidas G. Ioannou, Glen P. Kenny   +4 more
wiley   +1 more source

The brain of the archerfish Toxotes chatareus: A Nissl-based neuroanatomical atlas and catecholaminergic/cholinergic systems

Frontiers in Neuroanatomy, 2016
Over recent years, the seven-spot archerfish (Toxotes chatareus) has emerged as a new model for studies in visual and behavioral neuroscience thanks to its unique hunting strategy.
Naomi Karoubi, Ronen Segev, Mario F Wullimann   +2 more
doaj   +1 more source

Trace Elements Genetics: A Potential Role in Treatment‐Resistant Major Psychoses and Related Traits?

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Trace elements are pivotal to key biological processes, with possible effects on psychopathology. We investigated the hypothesis of shared genetic factors between trace elements levels, treatment resistance and related traits. We used genome‐wide summary statistics for trace elements blood concentration, treatment‐resistant depression (TRD ...
Chiara Fabbri, Alessandro Serretti, Marco Menchetti, Benedetta Vai, Francesco Benedetti, Lidia Fortaner‐Uyà, Concetta Crisafulli   +6 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

The Noradrenergic System in Parkinson’s Disease

Frontiers in Pharmacology, 2020
Nowadays it is well accepted that in Parkinson’s disease (PD), the neurodegenerative process occurs in stages and that damage to other areas precedes the neuronal loss in the substantia nigra pars compacta, which is considered a pathophysiological ...
Elena Paredes-Rodriguez, Elena Paredes-Rodriguez, Sergio Vegas-Suarez, Sergio Vegas-Suarez, Teresa Morera-Herreras, Teresa Morera-Herreras, Philippe De Deurwaerdere, Cristina Miguelez, Cristina Miguelez   +8 more
doaj   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source