Results 21 to 30 of about 17,260 (149)

Noradrenaline in Alzheimer’s Disease: A New Potential Therapeutic Target [PDF]

, 2022
A growing body of evidence demonstrates the important role of the noradrenergic system in the pathogenesis of many neurodegenerative processes, especially Alzheimer’s disease, due to its ability to control glial activation and chemokine production ...
Dello Russo, Cinzia, Gutiérrez, Irene L., Juan C. Leza, Leza Cerro, Juan Carlos, Novellino, F, García-Bueno, B, García Bueno, Borja, Cinzia Dello Russo, Caso, JR, Gutiérrez, IL, Novellino, Fabiana, Madrigal, JLM, Javier R. Caso, García-Bueno, Borja, Borja García-Bueno, José L. M. Madrigal, Leza, JC, Caso, Javier R., Muñoz Madrigal, José Luis, Leza, Juan C., Irene L. Gutiérrez, López Gutiérrez, Irene, Fabiana Novellino, Caso Fernández, Javier Rubén, Madrigal, José L. M., Dello Russo, C   +25 more
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Hippocampal seizures differentially modulate locus coeruleus activity and result in consistent time-locked release of noradrenaline in rat hippocampus

Neurobiology of Disease, 2023
The locus coeruleus (LC) is a small brainstem nucleus and is the sole source of noradrenaline in the neocortex, hippocampus and cerebellum. Noradrenaline is a powerful neuromodulator involved in the regulation of excitability and plasticity of large ...
Lars Emil Larsen, Sielke Caestecker, Latoya Stevens, Pieter van Mierlo, Evelien Carrette, Paul Boon, Kristl Vonck, Robrecht Raedt   +7 more
doaj   +1 more source

Diagnostic values of noradrenaline administered dose, procalcitonin (PCT) and blood lactic acid for septic shock [PDF]

Journal of Medical Biochemistry
Background: Sepsis/septic shock is a life-threatening condition that requires prompt and effective treatment. Noradrenaline is a widely used vasopressor to manage septic shock, but its optimal dosage remains unclear.
Ding Lili, Liu Mengru, Sun Haijun
doaj   +1 more source

Differences in Noradrenaline Receptor Expression Across Different Neuronal Subtypes in Macaque Frontal Eye Field

Frontiers in Neuroanatomy, 2020
Cognitive functions such as attention and working memory are modulated by noradrenaline receptors in the prefrontal cortex (PFC). The frontal eye field (FEF) has been shown to play an important role in visual spatial attention.
Max Lee, Adrienne Mueller, Tirin Moore, Tirin Moore   +3 more
doaj   +1 more source

Effect of noradrenaline on propofol-induced mitochondrial dysfunction in human skeletal muscle cells

Intensive Care Medicine Experimental, 2022
Background Mitochondrial dysfunction is a hallmark of both critical illness and propofol infusion syndrome and its severity seems to be proportional to the doses of noradrenaline, which patients are receiving.
Adéla Krajčová, Christine Skagen, Valér Džupa, Tomáš Urban, Arild C. Rustan, Kateřina Jiroutková, Bohumil Bakalář, G. Hege Thoresen, František Duška   +8 more
doaj   +1 more source

The renin‐angiotensin‐aldosterone system, neurohumoral axis and cardiovascular mortality in LURIC

The Journal of Clinical Hypertension, 2022
Although neurohormones and Renin‐Angiotensin‐Aldosterone‐System (RAAS) components are important predictors of cardiovascular mortality (CVM), their importance for predicting outcomes in patients with/without RAAS‐blockers and different degrees of ...
Babak Yazdani, Graciela E. Delgado, Marcus E. Kleber, Gökhan Yücel, Faeq Husain‐Syed, Thomas D. Kraemer, Jan Jochims, Jan Leipe, Winfried März, Bernhard K. Krämer   +9 more
doaj   +1 more source

Protocol for a randomised controlled trial of VAsopressin versus Noradrenaline as Initial therapy in Septic sHock (VANISH). [PDF]

, 2014
INTRODUCTION: Vasopressin is an alternative vasopressor in the management of septic shock. It spares catecholamine use but whether it improves outcome remains uncertain.
Brett, Stephen J., Gordon, AC, Perkins, GD, Brett, Stephen J, Brett, SJ, Mason, Alexina J., Mason, Alexina J, Ashby, D, Perkins, Gavin D., Gordon, Anthony C., Perkins, Gavin D, Ashby, Deborah, Mason, AJ, Gordon, Anthony C   +13 more
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Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography [PDF]

, 2012
Preliminary investigation of the radioiodinated (S,S)-reboxetine analogue, 123I-INER, in baboons showed this tracer to have promise for imaging the noradrenaline transporter (NAT) using single photon emission computed tomography (SPECT).
Sutherland, A., Tamagnan, G., Jobson, N.K., Batis, J., Tavares, A.A.S., Nicola K. Jobson, Sally L. Pimlott, Jeffery Batis, Dewar, D., Gilles Tamagnan, Deborah Dewar, Pimlott, S.L., Seibyl, J., Olivier Barret, Barret, O., Andrew Sutherland, Adriana Alexandre S. Tavares, John Seibyl   +17 more
core   +1 more source

Brief note about plasma catecholamines kinetics and submaximal exercise in untrained standardbreds

Annali dell'Istituto Superiore di Sanità, 2010
Four untrained standardbred horses performed a standardized exercise test on the treadmill and an automated blood collection system programmed to obtain blood samples every 15 s was used for blood collection in order to evaluate the kinetics of ...
Paolo Baragli, Sara Pacchini, Domenico Gatta, Michele Ducci, Claudio Sighieri   +4 more
doaj   +1 more source

Increased cyclooxygenase-2-derived prostanoids contributes to the hyperreactivity to noradrenaline in mesenteric resistance arteries from offspring of diabetic rats. [PDF]

PLoS ONE, 2012
This study analyzed the effect of in utero exposure to maternal diabetes on contraction to noradrenaline in mesenteric resistance arteries (MRA) from adult offspring, focusing on the role of cyclooxygenase (COX)-derived prostanoids.
Fernanda E Ramos-Alves, Diego B de Queiroz, Juliana Santos-Rocha, Gloria P Duarte, Fabiano E Xavier, Fabiano E Xavier   +5 more
doaj   +1 more source