Results 91 to 100 of about 397,901 (297)

Scalable training of L1-regularized log-linear models

open access: yes, 2007
The l-bfgs limited-memory quasi-Newton method is the algorithm of choice for optimizing the parameters of large-scale log-linear models with L2 regularization, but it cannot be used for an L1-regularized loss due to its non-differentiability whenever ...
Jianfeng Gao, Galen Andrew
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Computing Maximum Likelihood Estimates in Log-Linear Models

open access: yes, 2018
We develop computational strategies for extended maximum likelihood estimation, as defined in Rinaldo (2006), for general classes of log-linear models of widespread use, under Poisson and product-multinomial sampling schemes.
Alessandro Rinaldo (5363894)
core   +1 more source

Modelos de predição para sobrevivência de plantas de Eucalyptus grandis Prediction models of Eucalyptus grandis plant survival

open access: yesCiência e Agrotecnologia, 2009
Objetivou-se com este trabalho comparar modelos de predição de plantas sobreviventes de Eucalyptus grandis. Utilizaram-se os seguintes modelos: modelo linear misto com os dados transformados, utilizando-se as transformações angular e BOX-COX; modelo ...
Telde Natel Custódio, Décio Barbin
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

heatmap_llm – Supplemental material for Heatmaps for Patterns of Association in log-Linear Models

open access: yes, 2020
Supplemental material, heatmap_llm for Heatmaps for Patterns of Association in log-Linear Models by Mauricio Bucca in ...
Mauricio Bucca (6372308)
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

On Maximum Likelihood Estimation in Log-Linear Models

open access: yes, 2018
In this article, we combine results from the theory of linear exponential families, polyhedral geometry and algebraic geometry to provide analytic and geometric characterizations of log-linear models and maximum likelihood estimation.
Alessandro Rinaldo (5363894)
core   +1 more source

A Goodness-of-Fit Test for Log-Linearity in Cox Proportional Hazards Model Under Monotonic Covariate Effects

open access: yesMathematics
The Cox proportional hazards (PH) model is widely used because it models the covariates to the hazard through a log-linear effect. However, exploring flexible effects becomes desirable within the Cox PH framework when only a monotonic relationship ...
Huan Chen, Chuan-Fa Tang
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

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