Results 51 to 60 of about 3,443,781 (274)

High-dimensional simultaneous inference with the bootstrap

, 2016
We propose a residual and wild bootstrap methodology for individual and simultaneous inference in high-dimensional linear models with possibly non-Gaussian and heteroscedastic errors.
Bühlmann, Peter, Dezeure, Ruben, Zhang, Cun-Hui   +2 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Median Distance Model for Likert-Type Items in Contingency Table Analysis

Revstat Statistical Journal, 2023
Likert-type items (questions) are a widely used scale in questionnaire design. The “neutral” or “undecided” option may lead to misinterpretation and confusion about the results.
Serpil Aktas Altunay , Ayfer Ezgi Yilmaz   +1 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Novel Branches of (0,2) Theories

, 2012
We show that recently proposed linear sigma models with torsion can be obtained from unconventional branches of conventional gauge theories. This observation puts models with log interactions on firm footing.
A Adams, A D’Adda, A Strominger, C Quigley, Callum Quigley, CM Hull, D Andriot, D Nemeschansky, D Tong, DR Morrison, DR Morrison, E Witten, FF Gautason, J Gillard, J McOrist, JP Demailly, K Becker, K Becker, K Dasgupta, K Hori, K Hori, K Hori, M Blaszczyk, M Roček, Mark Stern, P Spindel, P Spindel, S Ivanov, Savdeep Sethi, SR Coleman, SR Green   +30 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Quantile Estimation Using the Log-Skew-Normal Linear Regression Model with Application to Children’s Weight Data

Mathematics, 2023
In this article, we establish properties that relate quantiles of the log-skew-normal distribution to its parameters, allowing us to investigate the relationship between quantiles of a positive skewed response variable and a set of explanatory variables ...
Raúl Alejandro Morán-Vásquez, Anlly Daniela Giraldo-Melo, Mauricio A. Mazo-Lopera   +2 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Heterogeneity among contingency tables diagnosed by hierarchical log-linear models and their effect on Biplots

Semina: Ciências Exatas e Tecnológicas, 2022
The theory of singular value decomposition of matched matrices is used to verify the heterogeneity of rows, columns and between matched two-way tables.
Carla Regina Guimarães Brighenti, Daniela Aparecida Mafra, Marcelo Angelo Cirillo   +2 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source