Results 101 to 110 of about 25,769,362 (302)
ClassicalGSG: Prediction of log P using classical molecular force fields and geometric scattering for graphs. [PDF]
J Comput Chem, 2021 Donyapour N, Hirn M, Dickson A.
europepmc +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
, 2018 The profile of variation in natural logarithm of the ratio of ensemble-averaged MSD to time,log (〈r2〉/t), with respect to the natural logarithm of time, log (t), is referred here as the log-log profile for simplicity. (A-G) Each plot demonstrates the log-
Rahul Gupta (358711)
core +1 more source
Physiological ReportsFew standardized tools are available for evaluation of disorders of consciousness (DOC). The potential of heart rate variability (HRV) during head‐up tilt (HUT) test was investigated as a complementary evaluation tool.
Weiqiang Cai +8 more
doaj +1 more source
Log ordinarity and log plurigenera of a proper SNCL scheme over a log point in characterisitic $p>0$
, 2020 In this article we give two applications of the spectral sequence of the log Hodge-Witt cohomology of a proper SNCL scheme over the log point of a perfect field of characterisitic $p>0$.
openaire +2 more sources
Dimeric polyphenols to pave the way for new antimalarial drugs. [PDF]
RSC Med Chem, 2023 Degotte G +6 more
europepmc +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
A Robust neural network approach for commodity flow distribution modelling tool
The Neural Network (NN) approach performance as a fully constraint spatial movement modelling tool is dependent upon its multi properties, like the training algorithm (TA).
Yue, Wen Long +2 more
core