Results 161 to 170 of about 104,140 (248)

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

open access: yesBritish Journal of Pharmacology, EarlyView.
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton   +6 more
wiley   +1 more source

Unraveling the active site cover of coproheme decarboxylase from Listeria monocytogenes

open access: yesThe FEBS Journal, EarlyView.
During heme biosynthesis in Gram‐positive bacteria, coproheme decarboxylase (ChdC) catalyzes the conversion of four‐propionate substrate coproheme to the two propionate product heme b. Its active site is universally covered by a flexible linking loop. This study identifies an important histidine residue, which stabilizes the loop in a ChdC homolog.
Nikolaus Falb   +4 more
wiley   +1 more source

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

open access: yesThe FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa   +1 more
wiley   +1 more source

Three‐dimensional three‐interval thixotropy test (3D‐3ITT) protocol for cosmetic lotions: A proof‐of‐concept study linking thixotropy to sensory and emotional responses

open access: yesInternational Journal of Cosmetic Science, EarlyView.
From rheology to emotion: 3D‐3ITT converts usage‐like shear histories into recovery maps and thixotropy index, TI3D. In a blinded half‐face study (N = 30), the higher‐ TI3D serum (S1s) improved absorption/clean feel and increased Relax and Comfort while lowering Anxiety relative to S2s.
Lihui Ye   +10 more
wiley   +1 more source

Quantum Models of Consciousness from a Quantum Information Science Perspective. [PDF]

open access: yesEntropy (Basel)
Gassab L   +3 more
europepmc   +1 more source

Effect of Cigarette Smoking on the Surface Roughness, Color, and Translucency of Zirconia Produced by Additive and Subtractive Manufacturing

open access: yesJournal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objective To compare the surface roughness, color stability, and translucency of zirconia produced by additive manufacturing (AM) and subtractive manufacturing (SM) after exposure to cigarette smoking. Materials and Methods A total of 60 disc‐shaped specimens were fabricated from 2 methods: AM (INNI Cera BCM W500/1000) and SM (VITA YZ T).
Bengisu Mahmutluoglu   +2 more
wiley   +1 more source

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