Results 151 to 160 of about 104,140 (248)

Finite-element-analysis of connection strength of assembled camshafts with different cam-bore profiles using tube hydroforming technology. [PDF]

Sci Rep, 2023
Ma J, Jiang Z, Lei J, Huang J, Liu J, Yang L, Wang H, Rong J.   +7 more
europepmc   +1 more source

Comparative Analysis of Stress Adaptation in the Yeast Microbiome of Cactus

Yeast, EarlyView.
Yeasts and related fungi isolated from cacti or nearby non‐cactus plants were characterized phenotypically and genomically, revealing differences that hint at modes of adaptation to the cactus host. ABSTRACT Together with other fungi, yeasts make up a significant component of the plant microbiome. As the planet warms, cacti expand their range.
Alya N. Hussain, Kevin T. Fotso, Michael A. McMurray   +2 more
wiley   +1 more source

Enhanced meta ensemble stacking approach with XGBoost and optuna based detection of Parkinson's disease. [PDF]

Front Digit Health
Joseph Raj AM, Kruthika SL, S A.
europepmc   +1 more source

Genetic risk factors in Finnish patients with Fuchs endothelial corneal dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To study the genetic risk factors of Fuchs endothelial corneal dystrophy (FECD) in the Finnish population using hospital‐based and large biobank cohorts. Methods We genotyped a cohort of 107 Finnish patients with FECD for the primary associated genetic risk factor, the TCF4 (CTG)>50 expansion, and studied their clinical phenotype.
Inka‐Tuulevi Vähämäki, Annamari T. Immonen, Joel T. Rämö, Aino M. Jaakkola, Kari Krootila, Maria Kaukonen, FinnGen, Aarno Palotie, Hannes Lohi, Tero T. Kivelä, Joni A. Turunen   +10 more
wiley   +1 more source

Expression and biochemical characterization of a patatin-like medium-chain esterase Rv1063c from <i>Mycobacterium tuberculosis</i>. [PDF]

Front Microbiol
Song Y, Dong S, Zhai R, Zhang M, Gao Z, Jia Y, Han W, Lin H.   +7 more
europepmc   +1 more source

Towards an ‘absolute’ timing of biostratigraphic and environmental phases from the Saalian late glacial to the Weichselian pleniglacial in central Europe—Insights from a lacustrine succession in Lichtenberg, northern Germany

Boreas, EarlyView.
Palynological records are central to the biostratigraphic subdivision of the Late Pleistocene in central Europe. Yet many interglacial and interstadial phases—such as the Eemian, Brörup and Odderade—remain only poorly constrained in time due to limited numerical dating.
Michael Hein, Thomas Kasper, Alexis Badai Samudra, Martin Theuerkauf, Markus Lothar Fischer, Neda Rahimzadeh, Maria Sekar Proborukmi, Sonja Rigterink, Agnieszka Gruszczyńska, Christian Zeeden, Simon Parfitt, David John Horne, Lucy Roberts, Dustin White, Lisa Brogmus, Hans von Suchodoletz, Tobias Lauer, Marcel Weiss, David Colin Tanner, Brigitte Urban   +19 more
wiley   +1 more source

The Greenwood function shows close alignment with pitch perceived by cochlear implant patients with long, flexible electrode arrays and fine-structure stimulation. [PDF]

Front Neurosci
Büchner A, Weller T, Penninger RT, Helpard L, Ladak HM, Agrawal S, Lenarz T, Schurzig D.   +7 more
europepmc   +1 more source

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, EarlyView.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source

Radial Hadamard-encoded ¹⁹F-MRI. [PDF]

MAGMA
Tadjalli Mehr K, Fischer J, Spreter F, Reiss S, Boll D, Özen AC, Gunashekar D, von Zur Mühlen C, Maier A, Bock M.   +9 more
europepmc   +1 more source

Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

British Journal of Pharmacology, EarlyView.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso, Jessica A. I. Muller, Yougang Zhang, Jean Giacomotto   +3 more
wiley   +1 more source