Results 61 to 70 of about 12,458 (247)

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

Advanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi   +7 more
wiley   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Flexible Dual-Band Ultrathin Frequency Selective Surface With Polarization Independence, Angular Stability, and Bending Insensitivity

IEEE Access
This paper introduces a novel ultrathin frequency selective surface (FSS) based on interconnected logarithmic spiral geometries. The structure is fabricated on a flexible polyimide substrate with a thickness of 0.05 mm, a relative permittivity of 4.3 ...
Maciel Alves de Oliveira, Ruann Victor de Andrade Lira, Alfredo Gomes Neto, Juliete da Silva Souza, Antonio Luiz Pereira de Siqueira Campos, Alexandre Jean Rene Serres   +5 more
doaj   +1 more source

Promotion of DFU Wound Healing via BRG1–COL16A1 Axis in Fibroblasts

Advanced Science, EarlyView.
In normal wound healing, transcription factor BRG1 is upregulated and binds the COL16A1 promoter to enhance its expression, promoting fibroblast proliferation, migration, contraction, extracellular matrix deposition, and granulation tissue formation, thus accelerating wound closure.
Penghui Wang, Jiaming Sun, Ying Wang, Bichen Ren, Yuxin Liu, Yunhan Liu, Liang Chen, Lu Yu, Tao Dai, Li Yu, Zhihui Dong   +10 more
wiley   +1 more source

Nuclear Spirals as Signatures of Supermassive Black Holes

, 2004
Recent high resolution images of spiral galaxies show wide varieties of features including nuclear spirals in the central parts. Some of the galaxies show grand-design nuclear spirals.
Ann, Hong Bae, Lee, Hyung Mok
core   +2 more sources

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Curves in Archeology: Computing the Volume of a Greek Vase

Metrology
The concept of dynamic symmetry in art and extensive measurements on Greek vases suggest that a vase and its parts can be inscribed into similar rectangles, with all rectangles having the same ratio of lengths of their side.
Siddhant Shah, Minfei Liang, Eugene Pinsky   +2 more
doaj   +1 more source

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

Advanced Science, EarlyView.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka, Richard T. Osgood, Hidetomi Nitta, Artur A. Indzhykulian   +3 more
wiley   +1 more source

A New View of the Spiral Structure of the Northern Outer Milky Way in Carbon Monoxide

The Astrophysical Journal Letters
Based on 32,162 molecular clouds from the Milky Way Imaging Scroll Painting project, we obtain new face-on molecular gas maps of the northern outer Galaxy. The total molecular gas surface density map reveals three segments of spirals, extending 16–43 kpc
Yan Sun, Ji Yang, Shaobo Zhang, Qing-Zeng Yan, Yang Su, Xuepeng Chen, Xin Zhou, Ye Xu, Hongchi Wang, Min Wang, Zhibo Jiang, Ji-Xian Sun, Deng-Rong Lu, Bing-Gang Ju, Xu-Guo Zhang, Min Wang   +15 more
doaj   +1 more source

Stationary perturbation configurations in a composite system of stellar and coplanarly magnetized gaseous singular isothermal discs

, 2003
We construct aligned and unaligned stationary perturbation configurations in a composite system of stellar and coplanarly magnetized gaseous singular isothermal discs (SIDs) coupled by gravity. In comparison with SID problems studied earlier, there exist
Beck, Beck, Bertin, Binney, Chakrabarti, Elmegreen, Fan, Fan, Fan, Ferguson, Frick, Frick, Galli, Goodman, Hohl, Jog, Jog, Jog, Kalnajs, Kalnajs, Kalnajs, Kato, Kennicutt, Krause, Lemos, Lin, Lin, Lin, Lou, Lou, Lou, Lou, Lou, Lou, Lou, Lou, Lou, Lou, Lowe, Mathewson, Mestel, Miller, Neininger, Neininger, Ostriker, Ostriker, Romeo, Safronov, Shen, Shen, Shu, Sofue, Sofue, Sukumar, Syer, Tacconi, Toomre, Toomre, Vandervoort, Vandervoort, Wang, Yu-Qing Lou, Yue Zou   +62 more
core   +1 more source