Results 71 to 80 of about 1,206,493 (389)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Prediction Method of Lithology Log Based on XGBoost Algorithm

Cejing jishu
The photoelectric absorption cross section index is an important parameter for lithology logging, and its measurement value is affected by environmental factors such as well diameter, drilling fluid density, and the gap between the logging instrument and
CHU Qingjun, GE Yunlong, TONG Maosong, WANG Yan, AN Lyuxing, YU Chuanwu, JIA Xin   +6 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Simulation Analysis of Soft Focusing of Azimuth Laterolog Resistivity Imaging LWD Tool

Cejing jishu
When logging while drilling directional lateral instruments work in formations, due to the long length of the drill collar, the surface potential attenuation is severe.
TANG Zhanghong, YANG Zhiliang, CHEN Gang, ZHANG Guoyan, ZHAI Xingyu, SONG Sen   +5 more
doaj   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Classification Evaluation Method for Complex Reservoirsin Xinglong Structural Belt

Cejing jishu
The reservoir of Linhe formation in the Xinglong tectonic belt of the Hetao basin is controlled by low geothermal temperature and late deep burial, with obvious weak diagenetic characteristics, strong heterogeneity of the reservoir, and complex pore ...
LI Xiaofeng, CAI Jun, XIAO Chengwen, CAI Wenyuan, YU Weigao, FU Shaoqing, GUO Yuqing   +6 more
doaj   +1 more source

Log–canonical forms and log canonical singularities

Mathematische Nachrichten, 2003
AbstractFor a normal subvarietyVof ℂnwith a good ℂ*–action we give a simple characterization for when it has only log canonical, log terminal or rational singularities. Moreover we are able to give formulas for the plurigenera of isolated singular points of such varieties and of the logarithmic Kodaira dimension ofV\{0}.
Zaidenberg, Mikhail, Flenner, Hubert
openaire   +4 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Application of Multi-Scale Borehole Acoustics Imaging Technology to Fracturing Effects Evaluation

Cejing jishu
Multiple types of waves co-existing in borehole acoustic logging, can provide various insights about the formation, because of their complementary investigation depth and perspectives. Focusing on ever-increasing needs in post-fracturing evaluation, this
SUN Xuekai, YU Chunhao, ZHANG Hao, ZHOU Jufeng, LIU Xianping   +4 more
doaj   +1 more source