Results 31 to 40 of about 696,327 (268)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Modalities in medieval logic [PDF]
, 2009 This dissertation is an exercise in conceptual archeology. Using the tools of contemporary logic we analyse texts in medieval logic and reconstruct their logical theories by creating a formal framework which models them. Our focus is medieval texts which
Uckelman, S.L., Uckelman, Sara L.
core
Logic Programming as Constructivism [PDF]
, 1989 The features of logic programming that seem unconventional from the viewpoint of classical logic can be explained in terms of constructivistic logic. We motivate and propose a constructivistic proof theory of non-Horn logic programming.
Bry, François
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Logical Nihilism and the Logic of ‘prem’
Logic and Logical Philosophy, 2020 As the final component of a chain of reasoning intended to take us all the way to logical nihilism, Russell (2018) presents the atomic sentence ‘prem’ which is supposed to be true when featuring as premise in an argument and false when featuring as conclusion in an argument. Such a sentence requires a non-reflexive logic and an endnote by Russell (2018)
openaire +4 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Informal Logic referees 2011-2012
, 2013 The Editors express their gratitude and appreciation to the indi-viduals listed below who served as referees for Informal Logic for Volumes 31 (2011) and 32 (2012)
Informal Logic Editors +1 more
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, 2023 Residuated basic logic (RBL) is the logic of residuated basic algebras, which constitutes a conservative extension of basic propositional logic (BPL). The basic implication is a residual of a non-associative binary operator in RBL.
Minghui Ma, Zhe Lin
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
An Introduction to Partition Logic [PDF]
, 2013 Classical logic is usually interpreted as the logic of propositions. But from Boole's original development up to modern categorical logic, there has always been the alternative interpretation of classical logic as the logic of subsets of any given ...
Ellerman, David
core +1 more source