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Logical Nihilism and the Logic of ‘prem’
Logic and Logical Philosophy, 2020 As the final component of a chain of reasoning intended to take us all the way to logical nihilism, Russell (2018) presents the atomic sentence ‘prem’ which is supposed to be true when featuring as premise in an argument and false when featuring as conclusion in an argument. Such a sentence requires a non-reflexive logic and an endnote by Russell (2018)
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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The Basic Intuitionistic Logic of Proofs [PDF]
, 2007 The language of the basic logic of proofs extends the usual propositional language by forming sentences of the sort x is a proof of F for any sentence F.
Artemov, S. +3 more
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
An Introduction to Partition Logic [PDF]
, 2013 Classical logic is usually interpreted as the logic of propositions. But from Boole's original development up to modern categorical logic, there has always been the alternative interpretation of classical logic as the logic of subsets of any given ...
Ellerman, David
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Fuzzy logics as the logics of chains
Fuzzy Sets and Systems, 2006 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Libor Behounek, Petr Cintula
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Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
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, 2022 This open access book makes a case for extending logic beyond its traditional boundaries, to encompass not only statements but also also questions. The motivations for this extension are examined in detail.
Ciardelli, Ivano
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Intelligent Tutoring Systems for Adult Learning in STEM Disciplines
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley +1 more source