Results 51 to 60 of about 991,150 (298)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Modalities in medieval logic [PDF]

open access: yes, 2009
This dissertation is an exercise in conceptual archeology. Using the tools of contemporary logic we analyse texts in medieval logic and reconstruct their logical theories by creating a formal framework which models them. Our focus is medieval texts which
Uckelman, S.L., Uckelman, Sara L.
core   +20 more sources

Logic frameworks for logic programs [PDF]

open access: yes, 1994
We show how logical frameworks can provide a basis for logic program synthesis. With them, we may use first-order logic as a foundation to formalize and derive rules that constitute program development calculi. Derived rules may be in turn applied to synthesize logic programs using higher-order resolution during proof that programs meet their ...
openaire   +4 more sources

The Logics of Strict-Tolerant Logic

open access: yesJournal of Philosophical Logic, 2014
A predicate \(T\) in a language is a transparent truth predicate if, for every valuation \(v\), for the language and every sentence \(A\), \(v(T\langle A\rangle) = v(A)\), where \(\langle A\rangle\) is a name of \(A\). Because of the semantic paradoxes, like the Liar and especially Curry's, it is well known that a suitably expressive language cannot ...
Eduardo Alejandro Barrio   +2 more
openaire   +3 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Inquisitive logic [PDF]

open access: yes, 2010
This paper investigates a generalized version of inquisitive semantics. A complete axiomatization of the associated logic is established, the connection with intuitionistic logic and several intermediate logics is explored, and the generalized version of
Ciardelli I   +6 more
core   +2 more sources

Logical Nihilism and the Logic of ‘prem’

open access: yesLogic and Logical Philosophy, 2020
As the final component of a chain of reasoning intended to take us all the way to logical nihilism, Russell (2018) presents the atomic sentence ‘prem’ which is supposed to be true when featuring as premise in an argument and false when featuring as conclusion in an argument. Such a sentence requires a non-reflexive logic and an endnote by Russell (2018)
openaire   +4 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

The Basic Intuitionistic Logic of Proofs [PDF]

open access: yes, 2007
The language of the basic logic of proofs extends the usual propositional language by forming sentences of the sort x is a proof of F for any sentence F.
Artemov, S.   +3 more
core  

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

open access: yesFEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court   +3 more
wiley   +1 more source

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