Results 41 to 50 of about 2,808 (225)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Benedict XVI and the Foundations of Politics
Wrocławski Przegląd TeologicznyThis article aims to present the political theology of Joseph Ratzinger/Benedict XVI. The first paragraph focuses on Ratzinger’s interpretation of selected New Testament source texts and the basic assumptions of what he called the “service to politics ...
Henryk Seweryniak
doaj +1 more source
Die Redekomposition wider "dieses Geschlecht" und seine Führung in der Redenquelle (vgl.Mt 23,1-39 par Lk 11,37-54) Bestand-Akoluthie-Kompositionsform [PDF]
, 2014 nicht ...
Schürmann, Heinz
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Protokolle zur Bibel, 2016 Das Logion vom hundertfachen bzw. vielfachen Lohn (Mk 10,29f; Mt 19,29;Lk 18,29f) unterscheidet in der markinischen Version deutlich zwischen der familia Dei als Vergeltung in diesem Äon und der ζωη αιωνιος im kommenden. Es verheißt diesen doppelten Lohn
Martin Stowasser
doaj
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
El Stromata VIII de Clemente de Alejandría [PDF]
, 2005 SUMARIO: 1. EL ESTADO DE LA CUESTION. 2. LA INVESTIGACION SOBRE LA AUTORfA Y COMPOSICION DEL TEXTO. 3. Los OBjETivos PROGRAMATICOS DE CLEMENTE. 4. Los cuATRO CLTIMOS CAPITULOS DE STROMATA V I L 5. EL LIBRO VIII DE LOS STROMATA. A.
Merino, M. (Marcelo)
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