Results 231 to 240 of about 126,178 (307)

Multivariate Poisson lognormal distribution for modeling counts from modern biological data: An overview. [PDF]

Comput Struct Biotechnol J
Subedi S, Dang UJ.
europepmc   +1 more source

Gold Nanoparticles Loaded With Lutetium‐177 Labeled DOTA‐TATE Exhibit Superior AR42J Cell Affinity and Extended Blood Circulation in AR42J Tumor Xenografts

Nano Select, Volume 7, Issue 2, February 2026.
The present study reports the development of a gold nanoparticle‐based delivery system functionalized with the established radiopharmaceutical [177Lu]Lu‐DOTA‐TATE. This design aims to enhance tumor‐targeting efficacy and improve the overall in vivo pharmacokinetic profile. In vitro studies demonstrated enhanced specificity toward somatostatin receptor (
Dheeraj Kumar, Rani Gnanasekar, Sheela Muralidharan, Shubhangi Mirapurkar, Krishna Mohan Repaka, Anupam Mathur, Madhava B. Mallia   +6 more
wiley   +1 more source

Optimized ACE2‐Fc fusion proteins with picomolar neutralization activity against highly evolved SARS‐CoV‐2 variants

Protein Science, Volume 35, Issue 2, February 2026.
Abstract The rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has compromised the efficacy of many authorized monoclonal antibody products. This highlights the need for alternative strategies, especially for vulnerable populations such as immunocompromised individuals.
Ferran Abancó, Ferran Tarrés‐Freixas, Rosalba Lepore, Elisa Molina‐Molina, Eloi Franco, Rytis Boreika, Edwards Pradenas, Dàlia Raïch‐Regué, Itziar Erkizia, Bonaventura Clotet, Alfonso Valencia, Júlia Vergara‐Alert, Joaquim Segalés, Jorge Carrillo, Nuria Izquierdo‐Useros, Julià Blanco, Benjamin Trinité   +16 more
wiley   +1 more source

Renal denervation for hypertension: cross-country cost-effectiveness insights from mainland China, Japan, and Thailand. [PDF]

Health Econ Rev
Lian D, Suo Y, Gai R, Li N, Ren Y, Xiao D, Zhao J, Zhang M, Liu S, Chen Y.   +9 more
europepmc   +1 more source

A Combined Model‐Based Meta‐Analysis of Aggregated and Individual FEV1 Data From Randomized COPD Trials

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Model‐based meta‐analysis allows integration of aggregated‐level data (AD) from different clinical trials in one model to assess population efficacy/safety. However, AD is limited in individual‐level information, while individual‐patient‐level data (IPD) are hard to obtain. Combined modeling may take advantage of both sources.
Liang Yang, Carolina Llanos‐Paez, Shuying Yang, Claire Ambery, Alienor Berges, Maria C. Kjellsson, Mats O. Karlsson   +6 more
wiley   +1 more source

Advancing wind energy potential estimation through multidistribution wind speed analysis in coastal Pakistan. [PDF]

Sci Rep
Abbas G, Ali A, Mushtaq Z, Rehman AU, Hussen S, Hamam H.   +5 more
europepmc   +1 more source

Tackling High Dimensionality in QSP: Guiding Model Order Reduction With Index Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Quantitative systems pharmacology (QSP) models offer a useful platform to integrate drug pharmacology with knowledge about biological mechanisms across multiple scales and data sources into a unified quantitative framework. This makes them invaluable to address many relevant questions in drug research and development.
Johannes Tillil, Wilhelm Huisinga, Jane Knöchel   +2 more
wiley   +1 more source

Generalized Galton's boards explain social phenomena via statistical physics. [PDF]

Sci Rep
Auricchio G, Ghiotto M, Gualandi S, Toscani G.   +3 more
europepmc   +1 more source

Immunogenicity Publication Bias and Its Consequences for Predictive Models: A Call for Transparent Reporting

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Understanding immunogenicity is crucial to improving therapeutic protein development. By comparing Phase I to III antidrug antibody (ADA) incidence data of Roche‐internal and approved monoclonal antibodies, we demonstrate a bias toward lower ADA incidence in published data, partly because ADA data from early trials—often discontinued for ...
Sophie Tascedda, Zicheng Hu, Hans Peter Grimm, Linnea C. Franssen   +3 more
wiley   +1 more source

Time dependent seismic fragility and serviceability assessment of reinforced concrete frames under chloride induced corrosion. [PDF]

Sci Rep
Kordtabar B, Dehestani M, Yazdanpanah O, Hasanzadeh A.   +3 more
europepmc   +1 more source