Results 91 to 100 of about 4,326 (212)

Tablet‐based Cognitive Assessment Tool (TabCAT) in a multisite study of early‐onset Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Brief digital cognitive measures may be a valuable and scalable alternative to traditional tests for improving early detection and disease monitoring in patients with early‐onset Alzheimer's disease (EOAD). METHODS We examined the convergent, diagnostic, and neuroanatomical validity of Tablet‐based Cognitive Assessment Tool ...
Wepnyu Yembe Njamnshi, Konstantinos Chiotis, Elena Tsoy, Ganna Blazhenets, Piyush Maiti, Jiaxiuxiu Zhang, Isabel Elaine Allen, Salma Rocha, Ranjani P. Shankar, Alinda Amuiri, Mawuli Lawson, Paul Aisen, Laurel Beckett, Ani Eloyan, Dustin B. Hammers, Kala Kirby, Robert Koeppe, Walter A. Kukull, Arthur W. Toga, Alireza Atri, David Clark, Gregory S. Day, Ranjan Duara, Neill R. Graff‐Radford, Ian Grant, Lawrence S. Honig, Erik C. B. Johnson, David T. Jones, Joseph Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Steven Salloway, Sharon J. Sha, Raymond Scott Turner, Thomas S. Wingo, David A. Wolk, Kyle Womack, Joel H. Kramer, Alexandra Touroutoglou, Michael J. Brickhouse, Clifford R. Jack Jr., Prashanthi Vemuri, Alexander Taurone, Maryanne Thangarajah, Kelly Nudelman, Maria C. Carrillo, Bradford C. Dickerson, Liana G. Apostolova, Katherine L. Possin, Gil D. Rabinovici, Renaud La Joie, LEADS Consortium   +54 more
wiley   +1 more source

Sensitivity of Speech Output to Delayed Auditory Feedback in Primary Progressive Aphasias

Frontiers in Neurology, 2018
Delayed auditory feedback (DAF) is a classical paradigm for probing sensori-motor interactions in speech output and has been studied in various disorders associated with speech dysfluency and aphasia.
Chris J. D. Hardy, Rebecca L. Bond, Kankamol Jaisin, Kankamol Jaisin, Charles R. Marshall, Lucy L. Russell, Katrina Dick, Sebastian J. Crutch, Jonathan D. Rohrer, Jason D. Warren   +9 more
doaj   +1 more source

Naming treatment in semantic and logopenic variant PPA [PDF]

, 2012
Primary progressive aphasia (PPA) is an acquired impairment of language caused by neurodegenerative disease affecting language regions in the brain. Unlike aphasia caused by stroke, the language impairments in PPA gradually worsen over time as atrophy ...
Gorno-Tempini, Maria Luisa, Henry, Maya L   +1 more
core  

The degraded concept representation system in semantic dementia:damage to pan-modal hub, then visual spoke [PDF]

, 2012
The core clinical feature of semantic dementia is a progressive yet selective degradation of conceptual knowledge. Understanding the cognitive and neuroanatomical basis for this deficit is a key challenge for both clinical and basic science.
Acosta-Cabronero, Antonucci, Baayen, Barsalou, Beauchamp, Binder, Binney, Bonner, Bonner, Bozeat, Bozeat, Breedin, Bright, Buxbaum, Capitani, Caramazza, Chao, Coltheart, Farah, Folstein, Funnell, Gainotti, Galantucci, Galton, Garrard, Goldberg, Goll, Gorno-Tempini, Hodges, Hodges, Hoffman, Hoffman, Hoffman, Ishibashi, Jefferies, Jefferies, Jefferies, Kellenbach, Kellenbach, Kiefer, Kiefer, Lambon Ralph, Lambon Ralph, Lambon Ralph, Lambon Ralph, Lambon Ralph, Lambon Ralph, Lewis, Luzzi, Macoir, Marinkovic, Martin, Martin, Matthew A. Lambon Ralph, Mayberry, Mion, Nestor, Papagno, Patterson, Patterson, Paul Hoffman, Pexman, Piwnica-Worms, Plaut, Pobric, Pobric, Pobric, Pulvermuller, Raven, Rogers, Rogers, Rogers, Rohrer, Roy W. Jones, Sharp, Snodgrass, Thompson-Schill, Tyler, Van Dam, Vandenberghe, Visser, Visser, Warrington, Warrington, Warrington, Wechsler, Woollams, Woollams, Yi   +88 more
core   +2 more sources

Single‐nuclei transcriptomic identifies neuronal populations vulnerable to AD by leveraging AD variants

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Individuals meeting neuropathological criteria for Alzheimer's disease (AD) can exhibit distinct clinical syndromes, suggesting region‐specific neuronal susceptibilities to tau pathology. Amnestic AD cases show greater tau burden in CA1, logopenic variant primary progressive aphasia (lvPPA) in the superior temporal gyrus (STG), and ...
Felipe Luiz Pereira, Caroline Lew, Song Hua Li, Liara Rizzi, Igor Prufer Q C Araujo, Alexander V. Soloviev, Salvatore Spina, Jessica E Rexach, William W. Seeley, Claudia Kimie Suemoto, Renata Elaine Paraizo Leite, Kathy L Newell, Bernardino Ghetti, Melissa E. Murray, Lea T. Grinberg   +14 more
wiley   +1 more source

Agnosia for accents in primary progressive aphasia. [PDF]

, 2013
As an example of complex auditory signal processing, the analysis of accented speech is potentially vulnerable in the progressive aphasias. However, the brain basis of accent processing and the effects of neurodegenerative disease on this processing are ...
Agustus, JL, Cifelli, A, Downey, LE, Fletcher, PD, Hailstone, JC, Schott, JM, Tyndall, MH, Warren, JD, Warrington, EK   +8 more
core   +1 more source

Non‐amnestic AD syndrome would exhibit WM differences from amnestic and other non‐amnestic syndromes

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background We have shown non‐amnestic Alzheimer's disease (AD) has greater white matter (WM) degeneration than amnestic AD. Understanding whether WM changes in AD are related to disease pathophysiology may be key to explaining the earlier onset and atypical tau distribution of non‐amnestic AD.
Briar Nowling, Hamsanandini Radhakrishnan, Christopher A Olm, Philip A. Cook, Katheryn A. Q. Cousins, Leslie M. Shaw, Allison Snyder, David J. Irwin, Corey T. McMillan, Lauren Massimo, Ilya M. Nasrallah, Jeffrey S Phillips   +11 more
wiley   +1 more source

Lewy Body Disease is a Contributor to Logopenic Progressive Aphasia Phenotype

Annals of Neurology, 2020
ObjectiveThe objective of this study was to describe clinical features, [18F]‐fluorodeoxyglucose (FDG)‐positron emission tomography (PET) metabolism and digital pathology in patients with logopenic progressive aphasia (LPA) and pathologic diagnosis of diffuse Lewy body disease (DLBD) and compare to patients with LPA with other pathologies, as well as ...
Marina Buciuc, Jennifer L. Whitwell, Koji Kasanuki, Jonathan Graff‐Radford, Mary M. Machulda, Joseph R. Duffy, Edythe A. Strand, Val J. Lowe, Neill R. Graff‐Radford, Beth K. Rush, Malgorzata B. Franczak, Margaret E. Flanagan, Matthew C. Baker, Rosa Rademakers, Owen A. Ross, Bernardino F. Ghetti, Joseph E. Parisi, Aditya Raghunathan, R. Ross Reichard, Eileen H. Bigio, Dennis W. Dickson, Keith A. Josephs   +21 more
openaire   +3 more sources

Digital Language Markers Differentiate Atypical Alzheimer's Disease Variants: Insights into Cognitive and Anatomical Mechanisms

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background The computational analysis of language has demonstrated significant diagnostic value in typical older‐onset Alzheimer's disease (AD). Here, we investigate whether digital language markers can distinguish between variants of atypical AD, including logopenic variant Primary Progressive Aphasia (lvPPA) and Posterior Cortical Atrophy ...
Neguine Rezaii, Yuta Katsumi, Daisy Hochberg, Nneka Watson, Megan Quimby, Brad C. Dickerson, Deepti Putcha   +6 more
wiley   +1 more source

Phonological Facilitation of Object Naming in Agrammatic and Logopenic Primary Progressive Aphasia (PPA): Evidence for a Phonological Processing Deficit [PDF]

, 2012
Naming is a pervasive deficit in primary progressive aphasia. However, the source of such deficits across PPA variants is little understood. In this study, individuals with agrammatic (PPA-G) and logopenic (PPA-L) PPA, along with age-matched controls ...
Cho-Reyes, Soojin, Kloet, James, Mack, Jennifer, Mesulam, M-Marsel, Thompson, Cynthia, Weintraub, Sandra, Wieneke, Christina   +6 more
core