Results 71 to 80 of about 34,580 (193)

Tau, amyloid, and hypometabolism in the logopenic variant of primary progressive aphasia [PDF]

Neurology, 2016
A 57-year-old right-handed woman had an 8-year history of progressive word retrieval and repetition deficits, consistent with the logopenic variant of Alzheimer disease.1 She was studied using the novel hyperphosphorylated-tau tracer 18F-AV-1451,2 in conjunction with metabolic (18F-fluorodeoxyglucose [FDG]) and β-amyloid (18F-florbetapir) PET (figure).
Belen, Pascual, Joseph C, Masdeu
openaire   +2 more sources

Clinical, Radiological, and Immunohistological Distinctions Between Limbic‐Predominant and Typical Alzheimer's Disease: A Systematic Review

Brain and Behavior, Volume 16, Issue 7, July 2026.
Abstract Background Alzheimer's disease (AD) is the most common cause of dementia worldwide and one of the leading causes of morbidity and mortality among elderly people. It is characterized by generalized brain atrophy, especially affecting the hippocampus and medial temporal lobe.
Guilherme Linha Secco, Kashif Qureshi, Murtaja Satea, Pedro Henrique Karpinski, Kim Wouters, Mateus Cordeiro Merlim da Silva, Sravan Reddy Ganta, Enzo von Quednow, Edgar Daniel Guzmán‐Ríos, Khalil St Brice, Mahi Dsouza, Ailton Fernandes Junior, Noor Najah Noori, Bipin Chaurasia, Kivanc Yangi   +14 more
wiley   +1 more source

The Indiana University Brain Health Program to deliver amyloid‐targeted therapy to Alzheimer's disease patients

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.
Abstract INTRODUCTION The Indiana University Brain Health Program was developed to support safe implementation of amyloid‐targeting therapies (ATTs) for early Alzheimer's disease (AD). METHODS We established Neurology Brain Health Navigators (neuroBHNs) to extend our Brain Health Navigator model into specialty care.
Jared R. Brosch, Sophia Wang, Liana G. Apostolova, Atul Agarwal, Jason W. Allen, Laurie Gutmann, Meredith Tobar, Linda Gonzalez, Dontraelle Johnson, Lindsay Treadway, Julie Connolly, Angela Tang, Ethan Lettich, Sam Davies, Nancy Kuhn, Dustin B. Hammers, David Clark, Martin Farlow, Deanna R. Willis, Nicole Fowler, Donna M. Wilcock   +20 more
wiley   +1 more source

Naming Compounds in Logopenic Primary Progressive Aphasia

Procedia - Social and Behavioral Sciences, 2012
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SEMENZA, CARLO, F. Vallese, F. Meneghello   +2 more
openaire   +2 more sources

Lewy Body Disease is a Contributor to Logopenic Progressive Aphasia Phenotype

Annals of Neurology, 2020
ObjectiveThe objective of this study was to describe clinical features, [18F]‐fluorodeoxyglucose (FDG)‐positron emission tomography (PET) metabolism and digital pathology in patients with logopenic progressive aphasia (LPA) and pathologic diagnosis of diffuse Lewy body disease (DLBD) and compare to patients with LPA with other pathologies, as well as ...
Marina Buciuc, Jennifer L. Whitwell, Koji Kasanuki, Jonathan Graff‐Radford, Mary M. Machulda, Joseph R. Duffy, Edythe A. Strand, Val J. Lowe, Neill R. Graff‐Radford, Beth K. Rush, Malgorzata B. Franczak, Margaret E. Flanagan, Matthew C. Baker, Rosa Rademakers, Owen A. Ross, Bernardino F. Ghetti, Joseph E. Parisi, Aditya Raghunathan, R. Ross Reichard, Eileen H. Bigio, Dennis W. Dickson, Keith A. Josephs   +21 more
openaire   +3 more sources

A Dextral Primary Progressive Aphasia Patient with Right Dominant Hypometabolism and Tau Accumulation and Left Dominant Amyloid Accumulation

Case Reports in Neurology, 2016
Background: Primary progressive aphasia (PPA) is a degenerative disease that presents as progressive decline of language ability with preservation of other cognitive functions in the early stages.
Young Kyoung Jang, Seongbeom Park, Hee Jin Kim, Hanna Cho, Chul Hyoung Lyoo, Sang Won Seo, Duk L. Na   +6 more
doaj   +1 more source

Distinct regional patterns of synaptic vulnerability across hippocampal and parahippocampal subregions in Alzheimer's disease

Brain Pathology, Volume 36, Issue 4, July 2026.
Synaptic loss in Alzheimer's disease predominantly affects the entorhinal cortex and parahippocampal gyrus. Amyloid‐β and p‐tau pathology show global associations with synaptic density but are limited in specific subregions. Instead, axonal damage associates with synaptic loss locally and in interconnected subregions.
Maud M. A. Bouwman, Irene Frigerio, Yvon Galis‐de Graaf, Wilma D. J. van de Berg, Laura E. Jonkman   +4 more
wiley   +1 more source

Evidence for a pervasive autobiographical memory impairment in Logopenic Progressive Aphasia

Neurobiology of Aging, 2021
Although characterized primarily as a language disorder, mounting evidence indicates episodic amnesia in Logopenic Progressive Aphasia (LPA). Whether such memory disturbances extend to information encoded pre-disease onset remains unclear. To address this question, we examined autobiographical memory in 10 LPA patients, contrasted with 18 typical ...
Siddharth Ramanan, David Foxe, Hashim El-Omar, Rebekah M. Ahmed, John R. Hodges, Olivier Piguet, Muireann Irish   +6 more
openaire   +2 more sources

Coexisting Logopenic Variant of Primary Progressive Aphasia with Amyloid Pathology and Early Parkinsonism

Journal of Alzheimer's Disease Reports
The presence of parkinsonism features in primary progressive aphasia (PPA) is a subject of ongoing research. These features are usually more pronounced in the advanced stages of the disease, particularly in the non-fluent/agrammatic subtype, and are ...
Martina Caccamo, Daniele Urso, Alfredo Gabriele Nanni, Valentina Gnoni, Alessia Giugno, Alessandra Vitulli, Davide Vilella, Chiara Zecca, Maria Teresa Dell’Abate, Antonio Anastasia, Roberto De Blasi, Alessandro Introna, Giancarlo Logroscino   +12 more
doaj   +1 more source

Improving the clinical trial landscape for patients with atypical variants of Alzheimer's disease: a call to action

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Patients with atypical variants of Alzheimer's disease (AD) often present at a younger age with predominantly non‐amnestic impairments and a more aggressive disease course. Historically, individuals with atypical presentations have not been included in large‐scale clinical trials, which typically focus on late‐onset, sporadic amnestic ...
Nick Corriveau‐Lecavalier, Neus Falgàs, Deepti Putcha, Jonathan Graff‐Radford, Keir X. X. Yong, Baayla D. C. Boon, Rosaleena Mohanty, Eric Westman, Colin Groot, David T. Jones, Lea T. Grinberg, Gil D. Rabinovici, Jennifer L. Whitwell, Liana G. Apostolova, Melissa E. Murray, Dustin B. Hammers, Suzanne E. Schindler, Inga Atonsdottir, Elizabeth K. Rhodus, Jonathan M. Schott, Ignacio Illán‐Gala, Chukwuanugo Ogbuagu, Jorge J. Llibre Guerra, Ruth Peters, Erin L. Abner, Carla Abdelnour, Albert Lladó, Renaud La Joie, Leonardo Cruz de Souza, Neguine Rezaii, Dror Shir, Yolande A. L. Pijenburg, Maria C. Carrillo, Bradford C Dickerson, Paul Aisen, Rik Ossenkoppele, Rema Raman   +36 more
wiley   +1 more source