Results 71 to 80 of about 2,380 (167)

Mapping Alzheimer's disease heterogeneity with molecular imaging biomarkers

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
This review outlines positron emission tomography (PET) biomarkers used in Alzheimer's disease (AD) research and clinical settings, targeting both specific (amyloid, tau) and non‐specific (neurodegeneration, synaptic density, neuroinflammation) processes.
Elif Harput, Cecilia Boccalini, Gregory Mathoux, John O. Prior, Nathalie Testart, Mario Jreige, Valentina Garibotto   +6 more
wiley   +1 more source

Progress in the last decade in our understanding of primary progressive aphasia

Annals of Indian Academy of Neurology, 2010
Primary progressive aphasia (PPA) is a focal neurodegeneration of the brain affecting the language network. Patients can have isolated language impairment for years without impairment in other areas.
Ratnavalli Ellajosyula
doaj  

Presentation of a clinical case of the logopenic form of the syndrome of primary progressive aphasia in the onset of Alzheimer’s disease

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева
A description of a clinical case of the logopenic form of the syndrome of primary progressive aphasia in the onset of Alzheimer’s disease is presented. The disease manifested itself in the form of speech and writing disorders, a sharp disorder in labor ...
Yu. V. Kotsiubinskaya, M. A. Kaigorodtsev, L. I. Sitnik, V. A. Mikhailov, Yu. P. Kolesova   +4 more
doaj   +1 more source

Development of language composites for enhanced sensitivity to multiple plasma biomarkers

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract BACKGROUND While language deficits are among the earliest detectable signs of Alzheimer`s disease (AD), no existing composites integrate connected speech – essential for capturing real‐world communication – limiting precise detection and personalized interventions.
Deling He, Rebecca E Langhough, Carol Van Hulle, Kristin Basche, Erin Jonaitis, Rachael Wilson, Bruce Hermann, Henrik Zetterberg, Sterling Johnson, Kimberly D. Mueller   +9 more
wiley   +1 more source

An Overview on Primary Progressive Aphasia and Its Variants

Behavioural Neurology, 2006
We present a review of the literature on Primary Progressive Aphasia (PPA) together with the analysis of neuropschychological and neuroradiologic profiles of 42 PPA patients.
Serena Amici, Maria Luisa Gorno-Tempini, Jennifer M. Ogar, Nina F. Dronkers, Bruce L. Miller   +4 more
doaj   +1 more source

Predicting primary progressive aphasias with support vector machine approaches in structural MRI data

NeuroImage: Clinical, 2017
Primary progressive aphasia (PPA) encompasses the three subtypes nonfluent/agrammatic variant PPA, semantic variant PPA, and the logopenic variant PPA, which are characterized by distinct patterns of language difficulties and regional brain atrophy.
Sandrine Bisenius, Karsten Mueller, Janine Diehl-Schmid, Klaus Fassbender, Timo Grimmer, Frank Jessen, Jan Kassubek, Johannes Kornhuber, Bernhard Landwehrmeyer, Albert Ludolph, Anja Schneider, Sarah Anderl-Straub, Katharina Stuke, Adrian Danek, Markus Otto, Matthias L. Schroeter   +15 more
doaj   +1 more source

Brain Perfusion, Atrophy, and Dopaminergic Changes in Amyloid Negative Logopenic Primary Progressive Aphasia

Scientific Reports
Although most cases of logopenic variant primary progressive aphasia (lvPPA) are caused by Alzheimer’s disease (AD), Lewy body disease (LBD) has also been reported.
Sungwoo Kang, Seun Jeon, Young-gun Lee, Mijin Yun, HyangHee Kim, Byoung Seok Ye   +5 more
doaj   +1 more source

An interdisciplinary approach aiding the diagnosis of primary progressive aphasia: A case report

Dementia & Neuropsychologia
Frontotemporal dementia (FTD) is one of the most common causes of early-onset dementia with primary progressive aphasia (PPA) being the second-most-frequent form of this degenerative disease.
Nadia Shigaeff, Mayra Zanetti, Sibelle de Almeida Tierno, Ana Beatriz Galhardi Di Tommaso, Thais Cristina Marques, Fábio Gazelato de Mello Franco   +5 more
doaj   +1 more source

Symptom‐based staging for logopenic variant primary progressive aphasia

European Journal of Neurology
AbstractBackground and purposeLogopenic variant primary progressive aphasia (lvPPA) is a major variant presentation of Alzheimer's disease (AD) that signals the importance of communication dysfunction across AD phenotypes. A clinical staging system is lacking for the evolution of AD‐associated communication difficulties that could guide diagnosis and ...
Chris Hardy, Cathleen Taylor‐Rubin, Beatrice Taylor, Emma Harding, Aida Suárez‐González, Jessica Jiang, Laura M. Thompson, Rachel Kingma, Anthipa Chokesuwattanaskul, Ffion Walker, Steve Barker, Emilie Brotherhood, Claire Waddington, Olivia Wood, Nikki Zimmermann, Nuriye Kupeli, Keir Yong, Paul M. Camic, Joshua Stott, Charles R. Marshall, Neil P. Oxtoby, Jonathan D. Rohrer, Frankie O'Shea, Anna Volkmer, Sebastian J. Crutch, Jason D. Warren   +25 more
openaire   +3 more sources

A fluência na afasia progressiva primária logopênica

Audiology: Communication Research
Esta pesquisa é um estudo de caso que tem como objetivo analisar, longitudinalmente, a fluência de um sujeito com Afasia Progressiva Primária (APP) Logopênica.
Karoline Pimentel dos Santos, Danieli Cristina Ribeiro, Ana Paula Santana   +2 more
doaj   +1 more source