Results 51 to 60 of about 2,380 (167)

Evidence for a pervasive autobiographical memory impairment in Logopenic Progressive Aphasia

Neurobiology of Aging, 2021
Although characterized primarily as a language disorder, mounting evidence indicates episodic amnesia in Logopenic Progressive Aphasia (LPA). Whether such memory disturbances extend to information encoded pre-disease onset remains unclear. To address this question, we examined autobiographical memory in 10 LPA patients, contrasted with 18 typical ...
Siddharth Ramanan, David Foxe, Hashim El-Omar, Rebekah M. Ahmed, John R. Hodges, Olivier Piguet, Muireann Irish   +6 more
openaire   +2 more sources

A decade with anomic primary progressive aphasia

eNeurologicalSci
Some patients with primary progressive aphasia (PPA) demonstrate only anomia. The lack of longitudinal observations of anomic PPA precluded us from determining whether progressive anomic aphasia was simply an early stage of semantic or logopenic variants,
Shoko Ota, Kazuo Kakinuma, Wataru Narita, Yoshiyuki Nishio, Nobuko Kawakami, Ayane Tamagake, Shigenori Kanno, Minoru Matsuda, Kyoko Suzuki   +8 more
doaj   +1 more source

Cognitive and Neural Mechanisms of Social Communication Dysfunction in Primary Progressive Aphasia

Brain Sciences, 2021
Mounting evidence suggests that, in parallel with well-defined changes in language, primary progressive aphasia (PPA) syndromes display co-occurring social cognitive impairments.
Zoë-Lee Goldberg, Hashim El-Omar, David Foxe, Cristian E. Leyton, Rebekah M. Ahmed, Olivier Piguet, Muireann Irish   +6 more
doaj   +1 more source

Cognitive reserve and longitudinal changes in brain and cognition in semantic variant primary progressive aphasia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Cognitive reserve (CR) refers to the brain's ability to maintain cognitive performance despite neurodegeneration. Studying CR in semantic variant primary progressive aphasia (svPPA) may clarify variability in disease progression and identify protective factors.
Lauren A. Grebe, Brittany T. Morin, Janhavi Pillai, David Paul Galang Baquirin, Buddhika Ratnasiri, Rian Bogley, Zoe Ezzes, Lisa D. Wauters, Maria Luisa Mandelli, Zachary A. Miller, Boon Lead Tee, Jessica de Leon, Kaitlin B. Casaletto, Howard J. Rosen, Maria Luisa Gorno Tempini, Elizabeth E. Galletta, Mira Goral, Jet M. J. Vonk   +17 more
wiley   +1 more source

Progranulin-associated PiB-negative logopenic primary progressive aphasia [PDF]

Journal of Neurology, 2014
The logopenic variant of primary progressive aphasia (lvPPA) strongly associates with Alzheimer's disease, but can also associate with frontotemporal lobar degeneration. We aimed to assess the frequency of lvPPA in patients with speech and language disorders without β-amyloid deposition, and to perform detailed neuroimaging and genetic testing in such ...
Keith A, Josephs, Joseph R, Duffy, Edythe A, Strand, Mary M, Machulda, Prashanthi, Vemuri, Matthew L, Senjem, Ralph B, Perkerson, Matthew C, Baker, Val, Lowe, Clifford R, Jack, Rosa, Rademakers, Jennifer L, Whitwell   +11 more
openaire   +2 more sources

Cognitive dispersion profiles and prediction of cognitive change in early‐onset dementias: Results from LEADS

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Research into cognitive dispersion – a cognitive process score measuring the intra‐individual variability (IIV) across a single testing session – suggests utility in neurodegenerative populations. Given widespread deficits observed in sporadic early‐onset Alzheimer's disease (EOAD), however, it is unclear if examining cognitive ...
Dustin B. Hammers, Elodie Foster, Ani Eloyan, Maryanne Thangarajah, Alexander Taurone, Alexandra Touroutoglou, Renaud La Joie, Laurel Beckett, Sujuan Gao, Prashanthi Vemuri, Kelly N. Nudelman, Kala Kirby, Jeffrey L. Dage, Paul Aisen, Alireza Atri, David Clark, Gregory S. Day, Ranjan Duara, Neill R. Graff‐Radford, Ian Grant, Lawrence S. Honig, Erik C. B. Johnson, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Leila Parand, Kyle Womack, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon J. Sha, Raymond Scott Turner, Thomas S. Wingo, David A. Wolk, Bradford C. Dickerson, Gil D. Rabinovici, Maria C. Carrillo, Liana G. Apostolova, the LEADS Consortium   +40 more
wiley   +1 more source

Clinical Correlates of Alzheimer's Disease Cerebrospinal Fluid Analytes in Primary Progressive Aphasia

Frontiers in Neurology, 2019
Background: While primary progressive aphasia (PPA) is associated with frontotemporal lobar degeneration (FTLD) pathology due to tau or TDP, clinical-pathological studies also demonstrate many cases have Alzheimer's disease (AD) pathology.
Catherine Norise, Molly Ungrady, Amy Halpin, Charles Jester, Corey T. McMillan, David J. Irwin, Katheryn A. Cousins, Murray Grossman   +7 more
doaj   +1 more source

Classification of primary progressive aphasia: challenges and complexities [version 1; peer review: 2 approved]

F1000Research, 2020
Primary progressive aphasia (PPA) is classified into three variants, logopenic variant PPA (lvPPA), nonfluent agrammatic PPA (nfaPPA), and semantic variant PPA (svPPA), based on clinical (syndromic) characteristics with support from neuroimaging and/or ...
Donna C. Tippett
doaj   +1 more source

Addressing Future Changes in Communication Using Hypothetical Scenarios With People With Primary Progressive Aphasia and Care Partners: A Conversation Analytic Study

International Journal of Language &Communication Disorders, Volume 61, Issue 3, May/June 2026.
ABSTRACT Background People with primary progressive aphasia (PPA) will experience a decline in language and cognitive function, and behavioural changes are not uncommon. Decline in everyday skills has been reported and becomes more pronounced over time.
Winsnes Ingvild, Halvorsen Mia, Krogh Elise, Volkmer Anna   +3 more
wiley   +1 more source

Refining Detection of Subclinical Epileptiform Activity in Alzheimer's Disease: A Case–Control Study and Call for a Consensus

Annals of Neurology, Volume 99, Issue 4, Page 1046-1058, April 2026.
[Color figure can be viewed at www.annalsofneurology.org] Objective Sleep‐predominant network hyperexcitability is increasingly recognized as a potential disease‐accelerating comorbidity in Alzheimer's disease (AD). However, its prevalence and risk‐factors remain debated, largely due to cohort‐specific and methodological differences across studies.
Anna B. Szabo, Jonathan Curot, Fleur Gérard, Florence Rulquin, Rachel Debs, Claire Georges, Marie Denuelle, Amel Bouloufa, Béatrice Lemesle, Patrice Péran, Claire Thalamas, Emmanuel J. Barbeau, Jérémie Pariente, Lionel Dahan, Luc Valton   +14 more
wiley   +1 more source