Results 41 to 50 of about 2,380 (167)
Tau, amyloid, and hypometabolism in the logopenic variant of primary progressive aphasia [PDF]
Neurology, 2016 A 57-year-old right-handed woman had an 8-year history of progressive word retrieval and repetition deficits, consistent with the logopenic variant of Alzheimer disease.1 She was studied using the novel hyperphosphorylated-tau tracer 18F-AV-1451,2 in conjunction with metabolic (18F-fluorodeoxyglucose [FDG]) and β-amyloid (18F-florbetapir) PET (figure).
Belen, Pascual, Joseph C, Masdeu
openaire +2 more sources
Heterogeneity of repetition abilities in logopenic variant primary progressive aphasia
Dementia & Neuropsychologia, 2021 . The differential diagnosis of primary progressive aphasia (PPA) is challenging due to overlapping clinical manifestations of the different variants of the disease.
Joel Macoir +4 more
doaj +1 more source
Journal of the Formosan Medical Association, 2017 Background/Purpose: To determine whether dual-phase 18F-florbetapir positron emission tomography imaging with perfusion-like and amyloid deposition information can distinguish among primary progressive aphasia (PPA), Alzheimer's disease (AD), and healthy
Hung-Chou Kuo +11 more
doaj +1 more source
Olfactory and imaging features in atypical Alzheimer’s disease
Translational Neuroscience, 2018 Cognition and speech disorders are the most common symptoms of dementia in neurodegenerative disease. Here, we present a detailed clinical evaluation of a case of logopenic variant of primary progressive aphasia (lv-PPA), an atypical form of Alzheimer ...
Huihong Zhang +6 more
doaj +1 more source
Thematic Integration Impairments in Primary Progressive Aphasia: Evidence From Eye-Tracking
Frontiers in Human Neuroscience, 2021 Primary progressive aphasia (PPA) is a degenerative disease affecting language while leaving other cognitive facilities relatively unscathed. The agrammatic subtype of PPA (PPA-G) is characterized by agrammatic language production with impaired ...
Matthew Walenski +5 more
doaj +1 more source
Brain Pathology, Volume 36, Issue 4, July 2026.Synaptic loss in Alzheimer's disease predominantly affects the entorhinal cortex and parahippocampal gyrus. Amyloid‐β and p‐tau pathology show global associations with synaptic density but are limited in specific subregions. Instead, axonal damage associates with synaptic loss locally and in interconnected subregions.
Maud M. A. Bouwman +4 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract Patients with atypical variants of Alzheimer's disease (AD) often present at a younger age with predominantly non‐amnestic impairments and a more aggressive disease course. Historically, individuals with atypical presentations have not been included in large‐scale clinical trials, which typically focus on late‐onset, sporadic amnestic ...
Nick Corriveau‐Lecavalier +36 more
wiley +1 more source
Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia
Dementia and Geriatric Cognitive Disorders Extra, 2016 Background/Aims: Frank agrammatism, defined as the omission and/or substitution of grammatical morphemes with associated grammatical errors, is variably reported in patients with nonfluent variant primary progressive aphasia (nfPPA). This study addressed
Naida L. Graham +8 more
doaj +1 more source
Posterior cortical atrophy in logopenic progressive aphasia: A case report
Frontiers in Communication, 2022 Posterior Cortical Atrophy (PCA) and Logopenic progressive aphasia (LPA) are nonamnestic variants of Alzheimer's disease (AD). Language deficits are a hallmark of LPA but not PCA.
Darshini Jeevendra Kumar +5 more
doaj +1 more source
The include network: Advancing cross‐linguistic equity in brain health research
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract Speech and language measures are increasingly recognized as sensitive, scalable, non‐invasive markers of diverse brain disorders. Yet, current research is overwhelmingly English‐centric, neglecting the world's vast linguistic diversity and undermining these markers’ global applicability.
Adolfo M. García +13 more
wiley +1 more source