Results 21 to 30 of about 2,380 (167)
The logopenic variant of primary progressive aphasia [PDF]
The aim is to explore the evolution of the logopenic variant of primary progressive aphasia as a distinct clinical entity and to outline recent advances that have clarified its clinical characteristics, neural underpinnings, and potential genetic and pathological bases.
Henry ML, Gorno Tempini, Maria Luisa
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Background The relatively isolated atrophy of the temporal lobes leads to a clinical radiological pattern, referred to as the temporal variant of frontotemporal dementia.
Thiago Paranhos +4 more
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The logopenic/phonological variant of primary progressive aphasia [PDF]
Primary progressive aphasia (PPA) is characterized by isolated decline in language functions. Semantic dementia and progressive nonfluent aphasia are accepted PPA variants. A "logopenic" variant (LPA) has also been proposed, but its cognitive and anatomic profile is less defined.
Gorno-Tempini, M L +9 more
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Microbleeds in the logopenic variant of primary progressive aphasia [PDF]
AbstractBackgroundMicrobleeds have been associated with Alzheimer's disease (AD), although it is unclear whether they occur in atypical presentations of AD, such as the logopenic variant of primary progressive aphasia (lvPPA). We aimed to assess the presence and clinical correlates of microbleeds in lvPPA.MethodsThirteen lvPPA subjects underwent 3T T2*‐
Jennifer L, Whitwell +10 more
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Background The Landscape Montage Technique was originally developed by Hisao Nakai, a Japanese psychiatrist, to pursue the possibility and application of a psychotherapeutic approach using drawing for patients with schizophrenia.
Masahiko Takaya +3 more
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Clinical Amyloid Imaging in Logopenic Progressive Aphasia [PDF]
The introduction of florbetapir (Amyvid) positron emission tomography biomarkers could dramatically change how we clinically evaluate young patients who present with nonamnestic cognitive complaints for possible Alzheimer disease (AD). Logopenic progressive aphasia (LPA) may be the most common example of this type of clinical problem.
Mario F, Mendez, Valeriy, Sabodash
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Primary progressive aphasias: clinical and genetic heterogeneity and diagnostic difficulties
This systematic review describes primary progressive aphasia (PPA) variants and includes the authors' own clinical observations. Over 20 genes have now been identified, with mutations that are directly involved in the development of the behavioural ...
Igor V. Litvinenko +3 more
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The Neural Basis of Logopenic Progressive Aphasia
Logopenic progressive aphasia (LPA) is defined clinically by impairments of naming and sentence repetition. The relationship between these impairments and their neural basis has, however, not yet been determined. We aimed to localize cortical thinning associated with naming and repetition deficits using cortical thickness measurements.
Leyton, Cristian E +5 more
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White matter disease correlates with lexical retrieval deficits in primary progressive aphasia
Objective: To relate fractional anisotropy changes associated with the semantic and logopenic variants of primary progressive aphasia to measures of lexical retrieval.Methods: We collected neuropsychological testing, volumetric MRI, and diffusion ...
John P. Powers +6 more
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Primary progressive aphasia is a neurodegenerative disorder that was recently classified into three types: fluent (semantic), nonfluent, and logopenic.
Stephanie M. Awad, Amer M. Awad
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