Results 11 to 20 of about 5,559,621 (201)

Formation of subhorizon black holes from preheating [PDF]

, 2014
We study the production of primordial black holes (PBHs) during the preheating stage that follows a chaotic inflationary phase. The scalar fields present in the process are evolved numerically using a modified version of the HLATTICE code.
E. Torres-Lomas, J. Hidalgo, Karim A. Malik, L. A. Urena-L'opez   +3 more
semanticscholar   +1 more source

Effect of ultrasonic waves on the water turbidity during the oxidation of phenol. Formation of (hydro)peroxo complexes.

Ultrasonics sonochemistry, 2017
Analysis of the kinetics of aqueous phenol oxidation by a sono-Fenton process reveals that the via involving ortho-substituted intermediates prevails: catechol (25.0%), hydroquinone (7.7%) and resorcinol (0.6%).
N. Villota, J. Lomas, L. Camarero
semanticscholar   +1 more source

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

Bioscience Reports, 2013
The common severe Z mutation (E342K) of α1-antitrypsin forms intracellular polymers that are associated with liver cirrhosis. The native fold of this protein is well-established and models have been proposed from crystallographic and biophysical data for
I. Haq, J. Irving, S. V. Faull, Jennifer A. Dickens, A. Ordóñez, D. Belorgey, B. Gooptu, D. Lomas   +7 more
semanticscholar   +1 more source

Reconstructing the Siluro-Devonian coastline of Gondwana: insights from the sedimentology of the Port Stephens Formation, Falkland Islands

Journal of the Geological Society, 2003
Silurian and lower Devonian sedimentary successions are uncommon within the remnants of Gondwana. The Port Stephens Formation, the basal unit of the middle Palaeozoic West Falkland Group, presents a rare opportunity to study Gondwanan material of Siluro ...
M. Hunter, S. A. Lomas
semanticscholar   +1 more source

Gamma ray log to estimate clay content in the layers of water boreholes

, 2021
This work describes a complete procedure to estimate the clay content of water-bearing layers in boreholes from gamma-ray logs using an optimised clay index, which conventionally is the normalised gamma-ray value in each layer with respect to the maximum
J. Díaz-Curiel, M. J. Miguel, B. Biosca, L. Arévalo-Lomas   +3 more
semanticscholar   +1 more source

The structural basis for Z α1-antitrypsin polymerization in the liver

Science Advances, 2020
α1-Antitrypsin polymers from human tissue have a structure most consistent with an intermolecular C-terminal domain swap. The serpinopathies are among a diverse set of conformational diseases that involve the aberrant self-association of proteins into ...
S. V. Faull, Emma L. K. Elliston, B. Gooptu, B. Gooptu, Bibek Gooptu, A. Jagger, I. Aldobiyan, Adam Redzej, M. Badaoui, Nina Heyer-Chauhan, S. Rashid, G. Reynolds, D. Adams, E. Miranda, E. Orlova, J. Irving, D. Lomas   +16 more
semanticscholar   +1 more source

Structural Dynamics Associated with Intermediate Formation in an Archetypal Conformational Disease

Structure, 2012
Summary In conformational diseases, native protein conformers convert to pathological intermediates that polymerize. Structural characterization of these key intermediates is challenging.
M. Nyon, Lakshmi Segu, Lisa D. Cabrita, G. Levy, J. Kirkpatrick, B. D. Roussel, A. Patschull, T. Barrett, U. Ekeowa, Richard Kerr, C. Waudby, N. Kalsheker, M. Hill, K. Thalassinos, D. Lomas, J. Christodoulou, B. Gooptu   +16 more
semanticscholar   +1 more source

A Kinetic Mechanism for the Polymerization of α1-Antitrypsin*

Journal of Biological Chemistry, 1999
The mutation in the Z deficiency variant of α1-antitrypsin perturbs the structure of the protein to allow a unique intermolecular linkage. These loop-sheet polymers are retained within the endoplasmic reticulum of hepatocytes to form inclusions that are ...
T. Dafforn, R. Mahadeva, P. Elliott, P. Sivasothy, D. Lomas   +4 more
semanticscholar   +1 more source

Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation*

Journal of Biological Chemistry, 2010
We have previously shown that overexpressing subunits of the iron-binding protein ferritin can rescue the toxicity of the amyloid β (Aβ) peptide in our Drosophila model system.
Beinan Liu, A. Moloney, Sarah Meehan, Kyle L. Morris, Sally E. Thomas, L. Serpell, Robert C. Hider, S. Marciniak, D. Lomas, D. Crowther   +9 more
semanticscholar   +1 more source

Shattered pellet injection experiments at JET in support of the ITER disruption mitigation system design

Nuclear Fusion, 2021
A series of experiments have been executed at JET to assess the efficacy of the newly installed shattered pellet injection (SPI) system in mitigating the effects of disruptions. Issues, important for the ITER disruption mitigation system, such as thermal
S. Jachmich, U. Kruezi, M. Lehnen, M. Baruzzo, L. Baylor, D. Carnevale, D. Craven, N. Eidietis, O. Ficker, T. Gebhart, S. Gerasimov, J. Herfindal, E. Hollmann, A. Huber, P. Lomas, J. Lovell, A. Manzanares, M. Maslov, J. Mlynar, G. Pautasso, C. Paz-Soldan, A. Peacock, L. Piron, V. Plyusnin, M. Reinke, C. Reux, F. Rimini, U. Sheikh, D. Shiraki, S. Silburn, R. Sweeney, J. Wilson, P. Carvalho, the JET Contributors   +33 more
semanticscholar   +1 more source