Results 261 to 270 of about 823,716 (355)

Circular RNA therapeutics: a new class of long-acting RNA medicines for oncology, immunology, and rare diseases. [PDF]

Front Immunol
Ugwu OP, Okon MB, Ogenyi FC, Ugwu JN, Ugwu CN.   +4 more
europepmc   +1 more source

ProTide generated long-acting abacavir nanoformulations

, 2018
Zhiyi Lin, Nagsen Gautam, Yazen Alnouti, JoEllyn McMillan, Aditya N. Bade, Howard E. Gendelman, Benson Edagwa   +6 more
openalex   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Microneedle-Based Technologies for Long-Acting Transdermal Drug Delivery in Wearable Devices. [PDF]

Sensors (Basel)
Luo J, Dai Y, Cheng X, Wang Z, Zhu Z.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Discontinuation of Long-acting Injectable Cabotegravir-Rilpivirine in a Large Clinic Cohort. [PDF]

Open Forum Infect Dis
Christopoulos KA, Erguera X, Grochowski J, Hickey M, Imbert E, Dilworth S, Appa A, Cox C, Shiels M, Oskarsson J, Gandhi M.   +10 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Correction: Clinical effectiveness of long-acting injectable antipsychotics in schizophrenia spectrum disorders: real-world mirror-image evidence. [PDF]

BMC Psychiatry
Kurt Tunagur EM, Tunagur MT.
europepmc   +1 more source