Results 31 to 40 of about 296,746 (277)
Merging short and stranded long reads improves transcript assembly.
PLoS Computational Biology, 2023 Long-read RNA sequencing has arisen as a counterpart to short-read sequencing, with the potential to capture full-length isoforms, albeit at the cost of lower depth.
Amoldeep S Kainth +3 more
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smsMap: mapping single molecule sequencing reads by locating the alignment starting positions
BMC Bioinformatics, 2020 Background Single Molecule Sequencing (SMS) technology can produce longer reads with higher sequencing error rate. Mapping these reads to a reference genome is often the most fundamental and computing-intensive step for downstream analysis. Most existing
Ze-Gang Wei, Shao-Wu Zhang, Fei Liu
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Genomic Structural Variations Within Five Continental Populations of Drosophila melanogaster
G3: Genes, Genomes, Genetics, 2018 Chromosomal structural variations (SV) including insertions, deletions, inversions, and translocations occur within the genome and can have a significant effect on organismal phenotype. Some of these effects are caused by structural variations containing
Evan Long +3 more
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Frontiers in Genetics, 2022 With the rapid development of single molecular sequencing (SMS) technologies such as PacBio single-molecule real-time and Oxford Nanopore sequencing, the output read length is continuously increasing, which has dramatical potentials on cutting-edge ...
Ze-Gang Wei +6 more
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Anatomy of a hash-based long read sequence mapping algorithm for next generation DNA sequencing [PDF]
, 2010 Motivation: Recently, a number of programs have been proposed for mapping short reads to a reference genome. Many of them are heavily optimized for short-read mapping and hence are very efficient for shorter queries, but that makes them inefficient or ...
Ankit Agrawal +3 more
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S-conLSH: alignment-free gapped mapping of noisy long reads [PDF]
BMC Bioinformatics, 2019 Abstract Background The advancement of SMRT technology has unfolded new opportunities of genome analysis with its longer read length and low GC bias. Alignment of the reads to their appropriate positions in the respective reference genome is the first but costliest step of any analysis pipeline
Chakraborty, Angana +5 more
openaire +5 more sources
Structural variant calling: the long and the short of it
Genome Biology, 2019 Recent research into structural variants (SVs) has established their importance to medicine and molecular biology, elucidating their role in various diseases, regulation of gene expression, ethnic diversity, and large-scale chromosome evolution—giving ...
Medhat Mahmoud +5 more
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iScience, 2023 Summary: Alternative transcription increases transcriptome complexity by expression of multiple transcripts per gene. Annotation and quantification of transcripts using short-read sequencing is non-trivial.
Christoph Andreas Engelhard +4 more
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, 2023 <p>PPoPP'24: AGAThA: Fast and Efficient GPU Acceleration of Guided Sequence Alignment for Long Read Mapping.</p ...
readwrite112
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Fast and sensitive mapping of nanopore sequencing reads with GraphMap
Nature Communications, 2016 Read mapping and alignment tools are critical for many applications based on MinION sequencers. Here, the authors present GraphMap, a mapping algorithm designed to analyze nanopore sequencing reads, that progressively refines candidate alignments to ...
Ivan Sović +5 more
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