Results 51 to 60 of about 5,359,748 (310)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A Longitudinal Examination of Post-COVID-19 Mortality in Residents in Long-Term Care Homes

Gerontology and Geriatric Medicine
The most adverse outcomes of the COVID-19 pandemic include high post-infection mortality among long-term care (LTC) home residents. Research about mortality over a longer period after contracting COVID-19 and in different pandemic years is limited.
Gordana Rajlic PhD, Janice M. Sorensen PhD, Akber Mithani MD   +2 more
doaj   +1 more source

Short and long term retention in antiretroviral care in health facilities in rural Malawi and Zimbabwe. [PDF]

, 2012
Despite the successful scale-up of ART services over the past years, long term retention in ART care remains a major challenge, especially in high HIV prevalence and resource-limited settings.
A Boulle, A Kagee, AD Harries, AD Harries, AD Harries, AK Chan, AL Gifford, AP Hardon, D Ekouevi, D Swendeman, DW Krebs, DW Lowrance, E Losina, E Wouters, EH Geng, F Cellettti, F Shumbusho, Freya Rasschaert, GP Bisson, H Bussmann, H Tweya, JK Yu, JM Tassie, JS Stringer, L Ferradini, L Myer, LG Bekker, Lut Lynen, M Callaghan, M Egger, M Massaquoi, M McGuire, M Posse, Marcel Manzi, MP Fox, MW Brinkhof, Olivier Koole, P Braitstein, R Cohen, R Elema, R Zachariah, R Zachariah, Rony Zachariah, RP Dalal, RT Lester, RT Lester, S Rosen, S Rosen, S Thai, SD Lawn, SD Lawn, T Decroo, T Decroo, United Nations General Assembly, W Van Damme, W Van Damme, Wim Van Damme, Y Assefa   +57 more
core   +4 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Patterns of psychotropic drug prescriptions and general practice consultations among community-dwelling older people with dementia during the first two years of the COVID-19 pandemic

BMC Geriatrics
Background The COVID-19 pandemic and subsequent lockdown measures had serious implications for community-dwelling older people with dementia. While the short-term impacts of the pandemic on this population have been well studied, there is limited ...
Jiamin Du, Huibert Burger, Thijmen Kupers, Karina Sulim, Maarten T. Homburg, Jean W. M. Muris, Tim C. olde Hartman, Sytse U. Zuidema, Lilian L. Peters, Sarah I. M. Janus   +9 more
doaj   +1 more source

Health Care Opinion Leaders' Views on the Future of Long-Term Care [PDF]

, 2008
Presents findings from a survey of experts on the challenges for long-term care -- securing adequate financing, developing the required healthcare workforce, and improving the quality of long-term care -- and strategies for addressing ...
Karen Davis, Mary Jane Koren, Michelle M. Doty   +2 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Clinical Frailty Scale and incidence of adverse outcomes in older patients with hip fractures in Qatar

Frontiers in Medicine
BackgroundStudies conducted on Western populations have shown that the Clinical Frailty Scale (CFS) is a major predictor of adverse outcomes in older patients with hip fractures; however, there are no data on Middle Eastern populations, who may be ...
Shirmila Syamala, Francisco José Tarazona-Santabalbina, Francisco José Tarazona-Santabalbina, Jorge Luis Passarelli, Brijesh Sathian, Navas Nadukkandiyil, Hanadi Al Hamad   +6 more
doaj   +1 more source

Long-term Care in Romania. ENEPRI Research Report No. 85, 15 June 2010 [PDF]

, 2010
Launched in January 2009, ANCIEN is a research project that runs for a 44-month period and involves 20 partners from EU member states. The project principally concerns the future of long-term care (LTC) for the elderly in Europe and addresses two ...
Popa, Daniela.
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source