Results 61 to 70 of about 2,070,306 (319)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Clinical Frailty Scale and incidence of adverse outcomes in older patients with hip fractures in Qatar

Frontiers in Medicine
BackgroundStudies conducted on Western populations have shown that the Clinical Frailty Scale (CFS) is a major predictor of adverse outcomes in older patients with hip fractures; however, there are no data on Middle Eastern populations, who may be ...
Shirmila Syamala, Francisco José Tarazona-Santabalbina, Francisco José Tarazona-Santabalbina, Jorge Luis Passarelli, Brijesh Sathian, Navas Nadukkandiyil, Hanadi Al Hamad   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Needs assessment survey among healthcare professionals to implement the 4Ms framework: a cross-sectional study from Qatar

The Aging Male
Background Worldwide, the evidence-based 4Ms framework of the Age-Friendly Health System (AFHS) improves the experience of caring for older adults. This study aimed to examine healthcare professionals’ perceptions, attitudes, and behaviors regarding the ...
Hanadi Al Hamad, Sameer Acharath Valappil, Brijesh Sathian   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Citizens as Active Participants in Integrated Care: Challenging the Field’s Dominant Paradigms

International Journal of Integrated Care, 2019
Policy makers, practitioners and academics often claim that care users and other citizens should be ‘at the center’ of care integration pursuits. Nonetheless, the field of integrated care tends to approach these constituents as passive recipients of ...
Ludo Glimmerveen, Henk Nies, Sierk Ybema
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The relation between resident-related factors and care problems in nursing homes: a multi-level analysis

BMC Health Services Research
Background Care problems such as decubitus and fall incidents are prevalent in nursing homes. Yet, research regarding explanatory factors on these care problems is scarce.
Suleyman Bouchmal, Yvonne M. J. Goërtz, Coen Hacking, Bjorn Winkens, Sil Aarts   +4 more
doaj   +1 more source

Long Term Care Ombudsman Annual Report 1993

, 1993
October, 1992 through September 30 ...
Kansas. Long Term Care Ombudsman
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source