Results 71 to 80 of about 5,359,748 (310)

Long-term foster care: different needs, different outcomes [PDF]

open access: yes, 2011
This brief examines where foster children are living four years after removal from their homes and the characteristics of these children and their placements. Understanding whether child characteristics such as age or emotional or behavioral problems are
Mattingly, Marybeth J., Walsh, Wendy A.
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Assessing old-age long-term care using the concepts of healthy life expectancy and care duration: the new parameter "Long-Term Care-Free Life-Expectancy (LTCF)" [PDF]

open access: yes
Achieving old ages is also connected with prevalence of illness and long-term care. With the introduction of the statutory long-term care insurance in 1996 and the long-term care statistics in 1999 research data of about 2.3 million people receiving long-
Anne Schulz, Rembrandt D. Scholz
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Measuring the Impact of Integrated Care: from Principles to Real-World Impact

open access: yesInternational Journal of Integrated Care, 2023
Jessica Michgelsen   +3 more
doaj   +1 more source

Differences in help-seeking behaviour between males and females with multiple pelvic floor symptoms: A qualitative study

open access: yesHeliyon
Background: Pelvic floor symptoms (PFS) are common and frequently co-occur, but few patients seek help despite negative effects on their quality of life. Moreover, most studies assessing help-seeking behaviour have only focused on a single PFS.
Kim Groot Wesseldijk   +4 more
doaj   +1 more source

Pre-admission assessment of elderly applicants to long-term care [PDF]

open access: yes, 2003
Aim: to identify whether pre-admission assessment of elderly applicants could be an effective means of identifying actual need for long term care Methods: 105 applicants to long term care were assessed at source for suitability for admission.
Dimech, Joseph, Fiorini, Anthony
core  

Finding a way: long-term care homes to support dementia [PDF]

open access: yes, 2015
An ageing demographic has increased the number of people with dementia. Although dementia is commonly associated with memory loss, other early symptoms include difficulty with wayfinding.
Alzheimer's Society   +20 more
core   +1 more source

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