Results 91 to 100 of about 2,070,306 (319)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Study of predictors of mortality among older residents with pneumonia in Qatar's long-term care facilities

Aging and Health Research
It is widely recognized that older adults are at an increased risk of contracting pneumonia, which may lead to significant adverse outcomes, including increased rates of morbidity and mortality. The primary aim of this retrospective study was to identify
Shafi Hashmath Ulla Khan, Al Anoud Al Fehaidi, Wasim Akram, Irshad Badarudeen, Mahmoud Ahmed Refaee, Noorudeen Kunnunmal, Asma Abbas, Osama Idris, Sheela Umakanth, Hanadi Al Hamad   +9 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Long Term Care Ombudsman Annual Report, 1994

, 1994
October 1, 1993, to September 30 ...
Kansas. Long Term Care Ombudsman
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Predictors of Actual Turnover Among Part‐Time Homecare Nurses in Japan: A Longitudinal Study

Journal of General and Family Medicine
Background High turnover among homecare nurses leads to nursing shortages and a decline in care quality. In Japan, part‐time nurses are crucial to the workforce.
Maiko Noguchi‐Watanabe, Noriko Yamamoto‐Mitani, Hanako Numata, Asa Inagaki‐Asano   +3 more
doaj   +1 more source

Analysis of outcomes from a geriatrician-led evidence-based falls prevention clinic: a retrospective study from Qatar

The Aging Male
Background Falls are an important health concern among older persons. This study attempted to evaluate the characteristics and risk factors of falls in older persons attending a geriatric falls clinic in Qatar, with a particular emphasis on the impact of
Hanadi Al Hamad, Brijesh Sathian
doaj   +1 more source

Long-term care in developing countries : ten case studies / editors: J. Brodsky, J. Habib and M. Hirschfeld

, 2003
Prepared in collaboration with the World Health Organization and the JDC-Brookdale Institute, the WHO Collaborating Centre for Health and Long-Term Care Policy and Research461 ...
World Health Organization, Habib, Jack, Brodsky, Jenny, Hirschfeld, Miriam J, WHO Collaborating Centre for Health and Long-Term Care Policy and Research   +4 more
core