Results 101 to 110 of about 4,590,611 (322)

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones, Samuele Bonomi, Keith E. Stockerl‐Goldstein, Randall J. Bateman   +3 more
wiley   +1 more source

Store-Operated Calcium Entry Is Required for mGluR-Dependent Long Term Depression in Cortical Neurons

Frontiers in Cellular Neuroscience, 2017
Store-operated calcium entry (SOCE) is a Calcium (Ca2+) influx pathway activated by depletion of intracellular stores that occurs in eukaryotic cells. In neurons, the presence and functions of SOCE are still in question.
Paloma González-Sánchez, Paloma González-Sánchez, Paloma González-Sánchez, Araceli del Arco, Araceli del Arco, Araceli del Arco, José A. Esteban, Jorgina Satrústegui, Jorgina Satrústegui, Jorgina Satrústegui   +9 more
doaj   +1 more source

miR-191 and miR-135 are required for long-lasting spine remodeling associated with synaptic long term depression

Nature Communications, 2014
Activity-dependent modification of dendritic spines, subcellular compartments accommodating postsynaptic specializations in the brain, is an important cellular mechanism for brain development, cognition and synaptic pathology of brain disorders.
Zhonghua Hu, Danni Yu, Qinhua Gu, Yanqin Yang, K. Tu, Jun Zhu, Zheng Li   +6 more
semanticscholar   +1 more source

Esketamine Nasal Spray Plus Oral Antidepressant in Patients With Treatment-Resistant Depression: Assessment of Long-Term Safety in a Phase 3, Open-Label Study (SUSTAIN-2).

Journal of Clinical Psychiatry, 2020
OBJECTIVE To evaluate long-term safety and efficacy of esketamine nasal spray plus a new oral antidepressant (OAD) in patients with treatment-resistant depression (TRD).
E. Wajs, L. Aluisio, R. Holder, E. Daly, R. Lane, P. Lim, Joyce E George, R. Morrison, G. Sanacora, A. Young, S. Kasper, A. Sulaiman, Cheng-Ta Li, J. Paik, H. Manji, D. Hough, Jennifer Grunfeld, H. Jeon, S. Wilkinson, W. Drevets, Jaskaran Singh   +20 more
semanticscholar   +1 more source

Long-term trends in depression among women separated from abusive partners [PDF]

, 2003
This study tested a cumulative adversity hypothesis, where differences in postseparation stressors among battered women were expected to lead to a widening gap in levels of women’s depression over time.
Anderson, D.K, Bybee, Deborah I., Saunders, Daniel G., Sullivan, Cris M., Yoshihama, Meiko   +4 more
core   +1 more source

Traumatic Microhemorrhages Are Not Synonymous With Axonal Injury

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diffuse axonal injury (DAI) is caused by acceleration‐deceleration forces during trauma that shear white matter tracts. Susceptibility‐weighted MRI (SWI) identifies microbleeds that are considered the radiologic hallmark of DAI and are used in clinical prognostication.
Karinn Sytsma, Rhonda Mittenzwei, Heather Maioli, Amanda Kirkland, C. Dirk Keene, Ramon Diaz‐Arrastia, Christine Mac Donald, Chiara Maffei, Brian L. Edlow, Amber L. Nolan   +9 more
wiley   +1 more source

Exercise is medicine for depression: even when the “pill” is small

Neuropsychiatric Disease and Treatment, 2016
Mats Hallgren,1 Davy Vancampfort,2,3 Brendon Stubbs4,5 1Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden; 2Department of Rehabilitation Sciences, 3University Psychiatric Centre – KU Leuven, KU Leuven &ndash ...
Hallgren M, Vancampfort D, Stubbs B
doaj  

Long-term outcomes in patients with severe depression after in-hospital treatment – study protocol of the depression long-term Augsburg (DELTA) study

BMJ Open, 2019
Introduction Depressive disorders are very common diseases entailing a great burden on affected people. However, comprehensive information on long-term disease course in patients with severe depression is lacking so far. The objectives of the DELTA study
Jakob Linseisen, Inge Kirchberger, Barbara Maleckar, Christine Meisinger, Max Schmauss, Jessica Baumgärtner   +5 more
doaj   +1 more source

O-GlcNAcylation of AMPA Receptor GluA2 Is Associated with a Novel Form of Long-Term Depression at Hippocampal Synapses

Journal of Neuroscience, 2014
Serine phosphorylation of AMPA receptor (AMPAR) subunits GluA1 and GluA2 modulates AMPAR trafficking during long-term changes in strength of hippocampal excitatory transmission required for normal learning and memory.
Erica Taylor, Kai Wang, Amy R. Nelson, Teruko M. Bredemann, Kyle Fraser, S. Clinton, Rosemary Puckett, R. Marchase, J. Chatham, L. McMahon   +9 more
semanticscholar   +1 more source

Clinically Relevant Outcome Measures in Women With Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adrenoleukodystrophy is a rare inherited peroxisomal disease caused by pathogenic variants in the ABCD1 gene located on the X chromosome. Although the most severe central nervous system and adrenal complications typically affect only men with adrenoleukodystrophy, the majority of women develop myeloneuropathy symptoms in adulthood.
Chenwei Yan, Elizabeth I. Pierpont, Amena S. Fine, Reena V. Kartha   +3 more
wiley   +1 more source