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Depression: A Long-Term Illness
British Journal of Psychiatry, 1994The realisation that major depression is often both chronic and recurrent has slowly begun to change the way that depression is diagnosed and treated. In particular, the need for continuation and maintenance treatment is an issue that now deserves increased attention, especially with the availability of new classes of antidepressant treatments, which ...
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Long-term Depression Overcomes Long-term Facilitation
Science Signaling, 2002In the short-term, a single neuron receiving multiple excitatory and inhibitory inputs at spatially distinct locales will sum all of them into the decision of whether or not to fire a nerve impulse. Guan et al. investigated the mechanisms whereby neurons integrate facilitatory and inhibitory inputs leading to long ...
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Calcium signals in long-term potentiation and long-term depression
Canadian Journal of Physiology and Pharmacology, 1999We describe postsynaptic Ca2+signals that subserve induction of two forms of neuronal plasticity, long-term potentiation (LTP) and long-term depression (LTD), in rat hippocampal neurons. The common induction protocol for LTP, a 1-s, 50-Hz tetanus, generates Ca2+increases of about 50 µM in dendritic spines of CA1 neurons.
J A, Connor +3 more
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Long-term depression in the CNS
Nature Reviews Neuroscience, 2010Long-term depression (LTD) in the CNS has been the subject of intense investigation as a process that may be involved in learning and memory and in various pathological conditions. Several mechanistically distinct forms of this type of synaptic plasticity have been identified and their molecular mechanisms are starting to be unravelled.
Collingridge, GL +3 more
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Long-Term Potentiation, Long-Term Depression, and Learning
1998Publisher Summary Almost everyone agrees that information is acquired, stored, and retrieved by the brain. All brains consist of individual cellular elements. Most neurons have the same parts: a dendritic tree, cell body, axon, and synaptic boutons.
Joe L. Martinez +2 more
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Annales medico-psychologiques, 1990
Our practice, in a unit of treatment of dysthymic state being confronted with problems of relapses and recurrences, we have questioned the therapeutic strategies in the long run and their possible assessments. After recalling conceptual and methodological reference about relapses, recurrences and therapeutic assessment, we propose the methods and first
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Our practice, in a unit of treatment of dysthymic state being confronted with problems of relapses and recurrences, we have questioned the therapeutic strategies in the long run and their possible assessments. After recalling conceptual and methodological reference about relapses, recurrences and therapeutic assessment, we propose the methods and first
openaire +1 more source
Long-Term Potentiation and Long-Term Depression
2018Synaptic connections in the brain can change their strength in response to patterned activity. This ability of synapses is defined as synaptic plasticity. Long lasting forms of synaptic plasticity, long-term potentiation (LTP), and long-term depression (LTD), are thought to mediate the storage of information about stimuli or features of stimuli in a ...
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The long-term management of depression
Journal of Psychopharmacology, 1995The long-term outlook for patients with unipolar depression is often poor. As few as one-fifth will remain well and a similar number will suffer chronic depression. It is now standard practice to extend acute treatment into a 4–6 month period of continuation therapy, and the value of prophylactic treatment over longer periods is becoming more widely ...
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Long-Term Potentiation and Long-Term Depression
Synaptic plasticity, the ability of chemical synapses to strengthen or weaken, has long been postulated to be a mechanistic basis of memory. Long-term potentiation (LTP), one form of synaptic plasticity, is defined as a persistent increase in the strength of synaptic transmission, whereas long-term depression (LTD) is the opposite—a persistent decreaseopenaire +1 more source