Results 211 to 220 of about 543,035 (258)
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The long-term management of depression
Journal of Psychopharmacology, 1995The long-term outlook for patients with unipolar depression is often poor. As few as one-fifth will remain well and a similar number will suffer chronic depression. It is now standard practice to extend acute treatment into a 4–6 month period of continuation therapy, and the value of prophylactic treatment over longer periods is becoming more widely ...
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A model for long-term potentiation and depression
Journal of Computational Neuroscience, 1995A computational model of long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus is presented. The model assumes the existence of retrograde signals, is in good agreement with several experimental data on LTP, LTD, and their pharmacological manipulations, and shows how a simple kinetic scheme can capture the essential ...
Migliore, M, Alicata, F, Ayala, GF
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Depression: A Long-Term Illness
British Journal of Psychiatry, 1994The realisation that major depression is often both chronic and recurrent has slowly begun to change the way that depression is diagnosed and treated. In particular, the need for continuation and maintenance treatment is an issue that now deserves increased attention, especially with the availability of new classes of antidepressant treatments, which ...
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Calcium signals in long-term potentiation and long-term depression
Canadian Journal of Physiology and Pharmacology, 1999We describe postsynaptic Ca2+signals that subserve induction of two forms of neuronal plasticity, long-term potentiation (LTP) and long-term depression (LTD), in rat hippocampal neurons. The common induction protocol for LTP, a 1-s, 50-Hz tetanus, generates Ca2+increases of about 50 µM in dendritic spines of CA1 neurons.
J A, Connor +3 more
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Long‐term treatment of depression with isocarboxazide
Acta Psychiatrica Scandinavica, 1980Isocarboxazide has been used as long‐term treatment for a selected group of 20 depressive patients, of whom some 90% (17/19) were non‐responders to treatment with tricyclic antidepressants. At the follow‐up the median duration of illness was 162 months, and the median duration of treatment was 42 months. Side‐effects and interactions were moderate thus
J K, Larsen, O J, Rafaelsen
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The Long-Term Outcome of Depressive Illness
British Journal of Psychiatry, 1988One hundred and forty-five patients with primary depressive illness admitted to a university hospital between 1966 and 1970 were followed up an average of 15 years later. Adequate data were obtained on 133 (92%) of the 145. During the follow-up period, 7% of the 133 had suicided, 12% had remained incapacitated by illness and only 20% had remained ...
L G, Kiloh, G, Andrews, M, Neilson
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Long-Term Depression: Cerebellum
2001Long-term depression (LTD) displayed in the cerebellar cortex is a persistent decrease of the transmission efficacy from granule cell to Purkinje cells. LTD is induced when two inputs to a Purkinje cell, one from a climbing fiber and the other from a set of granule cell axons, are repeatedly associated.
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Heterosynaptic long-term depression in the hippocampus
Journal of Physiology-Paris, 1996Heterosynaptic long-term depression (hetLTD) at one input can be induced by applying a conditioning stimulus to an adjacent set of synapses. In hippocampal CA1 pyramidal cells, our results suggest that hetLTD is triggered by an extracellular diffusible factor that is released following tetanic activation of NMDA receptors.
M, Scanziani, R A, Nicoll, R C, Malenka
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The Long-Term Outcome of Maudsley Depressives
British Journal of Psychiatry, 1988Eighty-nine consecutive admissions with primary depressive illness were prospectively ascertained and diagnosed in 1965–66 by R. E. Kendell, who also allocated each a position on a neurotic-psychotic continuum on the basis of previous discriminant function analysis. In 1983–84, 94% of the survivors were personally interviewed by a psychiatrist blind to
A S, Lee, R M, Murray
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The long-term stability of depressive subtypes
American Journal of Psychiatry, 1994This study used the concept of diagnostic stability to examine the validity of three subtypes of major depression.Patients with major depressive disorder (N = 424) were assigned baseline diagnoses according to structured interviews and the Research Diagnostic Criteria.
W, Coryell +5 more
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