Results 21 to 30 of about 4,459,968 (325)

Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons

Molecular Brain, 2022
Cyclin-dependent kinase 5 (Cdk5) /p35 is involved in many developmental processes of the central nervous system. Cdk5/p35 is also implicated in synaptic plasticity, learning and memory.
Miyuki Takahashi, Takeru Nakabayashi, Naoki Mita, Xiaohua Jin, Yuta Aikawa, Kodai Sasamoto, Goichi Miyoshi, Mariko Miyata, Takafumi Inoue, Toshio Ohshima   +9 more
doaj   +1 more source

Purkinje cells translate subjective salience into readiness to act and choice performance

Cell Reports, 2021
Summary: The brain selectively allocates attention from a continuous stream of sensory input. This process is typically attributed to computations in distinct regions of the forebrain and midbrain.
Lorenzo Bina, Vincenzo Romano, Tycho M. Hoogland, Laurens W.J. Bosman, Chris I. De Zeeuw   +4 more
doaj   +1 more source

Mapping dynamic interactions among cognitive biases in depression [PDF]

, 2020
Depression is theorized to be caused in part by biased cognitive processing of emotional information. Yet, prior research has adopted a reductionist approach that does not characterize how biases in cognitive processes such as attention and memory work ...
Bernstein, Amit, Everaert, Jonas, Joormann, Jutta, Koster, Ernst   +3 more
core   +1 more source

Long-term potentiation and long-term depression: a clinical perspective

Clinics, 2011
Long-term potentiation and long-term depression are enduring changes in synaptic strength, induced by specific patterns of synaptic activity, that have received much attention as cellular models of information storage in the central nervous system.
Timothy V.P. Bliss, Sam F. Cooke
doaj   +1 more source

Dependence receptor involvement in subtilisin-induced long-term depression and in long-term potentiation [PDF]

, 2016
The serine protease subtilisin induces a form of long-term depression (LTD) which is accompanied by a reduced expression of the axo-dendritic guidance molecule Unco-ordinated-5C (Unc-5C).
Darlington, L. Gail, Forrest, Caroline M., Stone, Trevor W.   +2 more
core   +1 more source

Long-term course of severe depression: late remission and recurrence may be found in a follow-up after 38-53 years

Mental Illness, 2012
This study is a follow-up of inpatients diagnosed with severe depression/melancholia between 1956 and 1969. During this period, all inpatients at the Department of Psychiatry, University Hospital, Lund, were rated on a multidimensional diagnostic ...
Lisa Crona, Louise Brådvik
doaj   +1 more source

Rho Signaling in Synaptic Plasticity, Memory, and Brain Disorders

Frontiers in Cell and Developmental Biology, 2021
Memory impairments are associated with many brain disorders such as autism, Alzheimer’s disease, and depression. Forming memories involves modifications of synaptic transmission and spine morphology.
Haorui Zhang, Haorui Zhang, Youssif Ben Zablah, Youssif Ben Zablah, Haiwang Zhang, Haiwang Zhang, Zhengping Jia, Zhengping Jia   +7 more
doaj   +1 more source

Bidirectional Synaptic Plasticity Is Driven by Sex Neurosteroids Targeting Estrogen and Androgen Receptors in Hippocampal CA1 Pyramidal Neurons

Frontiers in Cellular Neuroscience, 2019
Neuroactive estrogenic and androgenic steroids influence synaptic transmission, finely modulating synaptic plasticity in several brain regions including the hippocampus.
Alessandro Tozzi, Valentina Durante, Paolo Manca, Michela Di Mauro, Juan Blasi, Silvarosa Grassi, Paolo Calabresi, Suguru Kawato, Suguru Kawato, Vito Enrico Pettorossi   +9 more
doaj   +1 more source

Usability and Feasibility Study of a Remote Cognitive Behavioral Therapy System with Long-Term Unemployed Women [PDF]

, 2017
We present the results of the use of a cognitive behavioral therapeutic intervention tool to improve the mental, physical, and social health of a group of long-term unemployed women in Spain.
Aguilera, A, Ferrás, C, García, Y, Ávila, P   +3 more
core   +1 more source

Investigating the prevalence of anxiety and depression in people living with patellofemoral pain in the UK: the Dep-Pf Study [PDF]

, 2019
Patellofemoral pain (PFP) is a common knee condition causing pain around or behind the kneecap which is exacerbated by certain activities. Traditionally it has been viewed as a self-limiting condition.
Bannigan, Katrina, Wride, James
core   +1 more source