Results 301 to 310 of about 4,459,968 (325)

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial

Advanced Science, EarlyView.
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera, Suneesh Thilak, Asha Patel, Prashant Nasa, Zubair Ahmed, Lorraine Jacques, William J. Scotton, Cyril Chacko, Randeep Mullhi, Ruoling Chen, Vikram Patil, Suresh Renukappa, Tonny Veenith   +12 more
wiley   +1 more source

Systematic review on the efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) in the long-term management of treatment-resistant depression

Letícia da Fonte Porto Carreiro de Paula, Guilherme Barros Vieira de Mello, Cecília Avellar Diniz Rebêlo Távora, Paulo de Morais Andrade Lima Neto, Valdir Ribeiro, Bárbara Vieira, Paulo André Jordão de Paiva Serpa, Hayira Endy Ferreira de Souza, Pedro Duarte, João Cardoso, José Petrúcio de Siqueira Neto, F. Borges, Luana Tamiozzo Arraes, Rafaella de Souza Pereira Rodrigues, João P. S. Maurício de Carvalho   +14 more
openalex   +2 more sources

Global Evidence of the Unimodal Response of Ecosystem Respiration to Soil Moisture

Advanced Science, EarlyView.
Using global eddy covariance observations and a field experiment, this paper provides compelling evidence for the widespread unimodal relationship between soil moisture and ecosystem respiration and its water adaptation. Such knowledge facilitates understanding of soil moisture in affecting respiratory carbon emissions and has the potential to improve ...
Jinlong Peng, Shudi Xie, Jiwang Tang, Jiaqiang Liao, Chen Chen, Chuanlian Sun, Yiheng Wang, Qingping Zhou, Guirui Yu, Shuli Niu   +9 more
wiley   +1 more source

Advanced Stem Cell Therapy: 3D‐Bioprinted Brain‐Like Transplants for Alzheimer's Disease‐Like Dementia

Advanced Science, EarlyView.
A tri‐component biomimetic bioink(gelatin/alginate/fibrinogen) is developed to protect cells in critical pathological environments in AD. Using this bioink, a 3D‐printed NPC construct optimized for hippocampal transplantation is provided to improve cell retention and differentiation in an AD‐like model. This approach enhances memory recovery and offers
Ke Gai, Yu Song, Dawen Gao, Qingning Nie, Xiao Luo, Caizhe Xu, Changhao Cai, Austin Smith, Xiang Li, Wei Shi, Lei Zhang, Wei Sun, Feng Lin   +12 more
wiley   +1 more source

A Floating‐Gate Photoelectric Synaptic Transistor Utilizing BP/POx/WSe2 Heterostructure for Neuromorphic Visual Processing

Advanced Science, EarlyView.
In this paper, a novel floating gate transistor (BP/POx/WSe2) is developed, which enables rich synaptic functionality under optoelectronic conditions and can mimic human visual memory. By introducing a two‐path convolutional neural network that synergistically fuses optical and electronic inputs, it can achieve efficient feature extraction and weight ...
Yuxuan Zeng, Wenxing Lv, Zehai Hou, Weihua Huang, Zhipeng Yu, Zishuo Han, Rongbin Zhan, Tianle Zeng, Yawen Luo, Yu Lin, Weiming Lv, Bin Fang, Zhongming Zeng, Lianbo Guo   +13 more
wiley   +1 more source

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

Advanced Science, EarlyView.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang, Ling Jiang, Yibo Hu, Chuhan Fu, Jinhua Huang, Jing Chen, Qinghai Zeng   +6 more
wiley   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Long-Term Risk of Clinical Depression and Anxiety after Bariatric Surgery: A Population-Based Matched Cohort Study

Xiaochen Yang, Dong Xue, Susan A. Jebb, Paul Aveyard, Min Gao   +4 more
openalex   +1 more source