Results 321 to 330 of about 4,391,625 (378)

Genetic Evidence Supporting a Role for Brain Region Volume and Functional Network Alterations in Major Depression

Advanced Science, EarlyView.
Genome‐wide analyses indicate that reduced ventral diencephalon and thalamus volumes, along with decreased functional connectivity within the triple network (DMN/CEN/SN), are uniquely associated with the risk of major depression (MD) onset, compared to other similar severe psychiatric disorders.
Ming‐Min Xu, Nan Li, Yi‐Wen Lv, Wen‐Miao Yang, Zhi‐Yun Yu, Yi‐Min Zhang, Yu Guo, Xiao‐Yin Chen   +7 more
wiley   +1 more source

Targeting RBM10‐Repressed RORB Activity in Liquid Condensates Inhibits Lysosomal Biogenesis and Neuroblastoma Progression via Affecting NF‐κB Signaling

Advanced Science, EarlyView.
This study identifies that RBM10 represses the transcriptional activity of RORB in liquid condensates, resulting in down‐regulation of NR1D1 and RIOK3 that further activates NF‐κB activity to facilitate lysosomal biogenesis and aggressive features of NB cells.
Yanhua Guo, Xiaojing Wang, Chunhui Yang, Zhijie Wang, Xiaolin Wang, Xinyue Li, Jiaying Qu, Shunchen Zhou, Liduan Zheng, Qiangsong Tong   +9 more
wiley   +1 more source

ZnO Quantum Dots@CsPbBr3 Poly‐Heterocrystalline Film Enables High‐Performance Floating‐Gate Transistor Arrays for Edge Computing

Advanced Science, EarlyView.
The ZnO QDs@CsPbBr3 poly‐heterocrystalline film, featuring a semi‐coherent interface, delivers high electrical conductivity and excellent photoelectric properties. Functioning as a floating gate in photosensitive transistors, it enables high hole storage at 1 V and achieves a conductivity ratio of ≈3.57×105.
Jiajun Xu, Bo Tong, Nian Dai, Tongjian Liu, Zhibo Liu, Dingdong Zhang, Yan Liang, Song Qiu, Lai‐Peng Ma, Jinhong Du   +9 more
wiley   +1 more source

Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy

Advanced Science, EarlyView.
This review highlights the pivotal role of the nervous system in cancer progression, emphasizing how neural–tumor interactions—via synaptic signaling, neurotransmitters, and paracrine factors—reshape the tumor microenvironment. It introduces cancer neuroscience as an emerging field and proposes integrating advanced tools such as AI and optogenetics to ...
Mengyu Yuan, Rongjiao Xi, Yong Kang, Ming‐jie Kuang, Xiaoyuan Ji   +4 more
wiley   +1 more source

Anti‐Icing Organogel Enables Quasi‐Homogeneous Supercooling Preservation of Mouse Hearts

Advanced Science, EarlyView.
An organogel interface with a large energy barrier for ice nucleation is proposed to enable a quasi‐homogeneous supercooling preservation for organs. This method does not rely on cryoprotectant agents or machine perfusion and can double the ex vivo storage time of mouse hearts.
Junhao Li, Wei Wang, Chenghao Li, Lintao Kuang, Zhi Huang, Xing Chen, Zhenghao Guo, Kang Liu, Jinping Liu   +8 more
wiley   +1 more source

Atypical Hydrogen Bond Interaction Enables Anion‐Rich Solvation Structure in Polymer Electrolytes for High‐Voltage Flexible Lithium Metal Batteries

Advanced Science, EarlyView.
A high‐voltage, Li‐metal‐compatible, and highly conductive polymer electrolyte is reported by integrating a low‐solvating fluorinated plasticizer. Strong atypical hydrogen bonds formed between the plasticizer and polymer chains promote the establishment of anion‐rich solvation structure, effectively stabilizing electrolyte‐electrode interphase at the ...
Shujing Wen, Junhua Zhou, Guangzhao Zhang, Qingrong Wang, Chao Luo, Ruo Wang, Pengxian Li, Chaoyang Wang, Xiaoxiong Xu, Yonghong Deng, Jian Chang, Zijian Zheng   +11 more
wiley   +1 more source

Structure‐Function Relationships of Biomass‐Derived Materials for Zinc Metal Protection

Advanced Science, EarlyView.
This review analyses the mechanism of zinc anode degradation, focuses on the protective roles of the four major functional groups of carboxyl, amino, hydroxyl, and sulfonic acid groups in biomass materials, reveals the structure‐function relationship and synergistic effects of functional groups, and looks forward to the challenges and directions of ...
Qiwei Gao, Zhuo Chen, Ya He, Zhangxiang Hao, Junrun Feng   +4 more
wiley   +1 more source

Flexible Memory Application of Nanoscale Ti–Ge–Te Thin Film as Information Storage Medium With Excellent Thermal Stability, Low Resistance Drift and Superior Bending Characteristic

Advanced Science, EarlyView.
Nanoscale Ti–Ge–Te films were fabricated via magnetron co‐sputtering, exhibiting the exceptional thermal stability, low resistance drift, and superior mechanical flexibility. Density functional theory reveals Ti doping can convert GeTe to a direct bandgap semiconductor and enhance covalent Ti–Te bonding. Flexible phase‐change memory devices demonstrate
Han Gu, Weihua Wu, Xiaochen Zhou, Pei Zhang, Bowen Fu, Jiwei Zhai, Sannian Song, Zhitang Song   +7 more
wiley   +1 more source

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

Advanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni, He Chen, Qiaqi Chen, Yangyang Liao, Yunqian Wang, Linyan Ye, Xiaohui Wu, Hongyu Ni, Tingyun Jiang, Shufen Li, Qiong Yang, Hong Xue, Zhongju Wang, Feng Yi, Cunyou Zhao   +14 more
wiley   +1 more source

Analyses of GWAS and Sub‐Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk

Advanced Science, EarlyView.
A cost‐effective strategy is developed analyzing sub‐threshold GWAS loci (5 × 10−8 < P ≤ 10−6), identifying 180 risk loci and 304 high‐confidence genes through combined GWAS/subGWAS analysis. This approach reveals dendrite development and morphogenesis (DDM) as a novel SCZ pathway.
Rui Chen, Benjamin Siciliano, Quan Wang, Chongchong Xu, Qiang Wei, Hai Yang, James S Sutcliffe, Yi Jiang, Ying Ji, Chunyu Liu, Feixiong Cheng, Edwin H Cook, Nancy J Cox, Xue Zhong, Zhexing Wen, Bingshan Li   +15 more
wiley   +1 more source