Results 51 to 60 of about 9,825,522 (293)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Computer simulations of developmental change: The contributions of working memory capacity and long-term knowledge [PDF]

, 2008
Increasing working memory (WM) capacity is often cited as a major influence on children’s development and yet WM capacity is difficult to examine independently of long-term knowledge.
Pine, JM, Julian M. Pine, Fernand Gobet, Gary Jones, Jones, G, Gobet, F   +5 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Dependency-based long short term memory network for drug-drug interaction extraction

BMC Bioinformatics, 2017
Background Drug-drug interaction extraction (DDI) needs assistance from automated methods to address the explosively increasing biomedical texts. In recent years, deep neural network based models have been developed to address such needs and they have ...
Wei Wang, Xi Yang, Canqun Yang, Xiaowei Guo, Xiang Zhang, Chengkun Wu   +5 more
doaj   +1 more source

The capacity of human memory: Is there any limit to human memory?

Journal of Research on English and Language Learning, 2020
There exist some estimates of the capacity of human memory. Recent studies have proven the fact that Long Term Memory is subject to constant reconfigurations mostly at lower levels of neural clusters.
Ehsan Namaziandost, Meisam Ziafar
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Forecasting Air Quality Indeks Using Long Short Term Memory

Journal of Applied Informatics and Computing
Exercise offers significant physical and mental health benefits. However, undetected air pollution can have a negative impact on individual health, especially lung health when doing physical activity in crowded sports venues.
Irfan Wahyu Ramadhani, Filmada Ocky Saputra, Ricardus Anggi Pramunendar, Galuh Wilujeng Saraswati, Nurul Anisa Sri Winarsih, Muhammad Syaifur Rohman, Danny Oka Ratmana, Guruh Fajar Shidik   +7 more
doaj   +1 more source

Stress and long-term memory retrieval: a systematic review

Trends in Psychiatry and Psychotherapy, 2020
Introduction The experience of stressful events can alter brain structures involved in memory encoding, storage and retrieval. Here we review experimental research assessing the impact of the stress-related hormone cortisol on long-term memory retrieval.
Cadu Klier, Luciano Grüdtner Buratto
doaj   +1 more source