Results 61 to 70 of about 2,305,737 (285)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The capacity of human memory: Is there any limit to human memory?

Journal of Research on English and Language Learning, 2020
There exist some estimates of the capacity of human memory. Recent studies have proven the fact that Long Term Memory is subject to constant reconfigurations mostly at lower levels of neural clusters.
Ehsan Namaziandost, Meisam Ziafar
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Stress and long-term memory retrieval: a systematic review

Trends in Psychiatry and Psychotherapy, 2020
Introduction The experience of stressful events can alter brain structures involved in memory encoding, storage and retrieval. Here we review experimental research assessing the impact of the stress-related hormone cortisol on long-term memory retrieval.
Cadu Klier, Luciano Grüdtner Buratto
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Forecasting Air Quality Indeks Using Long Short Term Memory

Journal of Applied Informatics and Computing
Exercise offers significant physical and mental health benefits. However, undetected air pollution can have a negative impact on individual health, especially lung health when doing physical activity in crowded sports venues.
Irfan Wahyu Ramadhani, Filmada Ocky Saputra, Ricardus Anggi Pramunendar, Galuh Wilujeng Saraswati, Nurul Anisa Sri Winarsih, Muhammad Syaifur Rohman, Danny Oka Ratmana, Guruh Fajar Shidik   +7 more
doaj   +1 more source

Long-term memory persistence

Future Neurology, 2010
Memories lasting 6–24 h or more are usually called long-term memories. Some of them, however, persist just a couple of days, and others last months or years. Recent studies have described a delayed post-training phase that induces memory persistence. Two mechanisms have been described in rodents immediately after hippocampal cellular consolidation is ...
Ivan Izquierdo, Martin Cammarota, Jorge H Medina   +2 more
openaire   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Dependency-based long short term memory network for drug-drug interaction extraction

BMC Bioinformatics, 2017
Background Drug-drug interaction extraction (DDI) needs assistance from automated methods to address the explosively increasing biomedical texts. In recent years, deep neural network based models have been developed to address such needs and they have ...
Wei Wang, Xi Yang, Canqun Yang, Xiaowei Guo, Xiang Zhang, Chengkun Wu   +5 more
doaj   +1 more source