Results 61 to 70 of about 218,957 (288)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

1268 A cbt intervention for long term sickness absence [PDF]

Work Disability Prevention and Integration, 2018
Introduction The longer an individual is out of work the less likely that individual will ever return to work. Research has shown that, after six consecutive months of absence an individual has only a 50% chance of returning to work, this falls to 20% after 12 months’ continuous absence and 10% after 24 months’ continuous absence.
Lorraine Begley, Thérèsse Hodgins, John Mc Dermott   +2 more
openaire   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Gender differences in sickness absence and the gender division of family responsibilities [PDF]

, 2013
This study investigates possible reasons for the gender difference in sickness absence. We estimate both short- and long-term effects of parenthood in a within-couple analysis based on the timing of parenthood.
Angelov, Nikolay, Johansson, Per, Lindahl, Erica   +2 more
core   +2 more sources

Addressing long-term sickness absence: moving beyond disease, illness and work-related factors for effective prevention

Scandinavian Journal of Work, Environment & Health, 2017
Although only a relatively small percentage of workers report sick for longer than a few days or weeks, it should be noted that long-term sickness absence constitutes the major part of the already substantial costs of sickness absence for companies and ...
Ludovic GPM van Amelsvoort, Nicole WH Jansen, IJmert Kant   +2 more
doaj   +1 more source

Prevention of sickness absence through early identification and rehabilitation of at-risk patients with musculoskeletal pain (PREVSAM): a randomised controlled trial protocol

BMC Musculoskeletal Disorders, 2020
Background Musculoskeletal pain is globally a leading cause of physical disability. Many musculoskeletal-related pain conditions, such as low back pain, often resolve spontaneously.
MEH Larsson, L. Nordeman, K. Holmgren, A. Grimby-Ekman, G. Hensing, C. Björkelund, S. Bergman, A. Ekhammar, M. Dottori, S. Bernhardsson   +9 more
doaj   +1 more source

Returning and staying connected to work after long-term sickness absence [PDF]

Occupational Medicine, 2016
Returning to work (RTW) after long-term sickness absence is a challenge for convalescent workers, co-workers, managers and organizations. Few studies have investigated the post-return phase after long-term sickness absence.To investigate the RTW process as experienced by returning workers, co-workers and managers at an emergency care service and a ...
Petersen, K S, Labriola, M, Nielsen, Claus Vinther, Larsen, Eva Ladekjær   +3 more
openaire   +3 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Impact of psychosocial characteristics in neck and low back pain : Long-term outcome and prognosis concerning sick leave [PDF]

, 2011
Background: Neck pain (NP) and low back pain (LBP) are common, disabling and extremely costly health issues in the industrial world, and the problem does not seem to be declining.
Bergström, Cecilia
core   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source