Results 71 to 80 of about 3,384,181 (301)

Medial Superior Olivary Neurons Receive Surprisingly Few Excitatory and Inhibitory Inputs with Balanced Strength and Short-Term Dynamics [PDF]

, 2010
Neurons in the medial superior olive (MSO) process microsecond interaural time differences, the major cue for localizing low-frequency sounds, by comparing the relative arrival time of binaural, glutamatergic excitatory inputs. This coincidence detection
Couchman, Kiri, Felmy, Felix, Grothe, Benedikt   +2 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

ANALYSIS LAYER MODEL OF POLYMER COMPOSITE DESIGN UNDER MULTIFACTOR LOADING

Вестник Донского государственного технического университета, 2018
A mathematical model is offered for the analysis of complex stress-strain state of the layer load-carrying structures of the aircraft planes. It is presented as sets of the equations of the constraining relations of load parameters, voltages and ...
Oleg G. Osyaev, Yury A. Taturin, Alexey M. Kostin, Artur V. Zhukov   +3 more
doaj  

Prestress loss of post-tensioned clay diaphragm and fin brickwork [PDF]

, 1994
Unlike calcium silicate and concrete block masonry which undergo shrinkage with time, clay brickwork has been known to expand instead. Expansion of brick units in prestressed masonry will cause an increase in the prestressing force instead of prestress ...
Tapsir, Siti Hamisab
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Long term effects of lead contaminated water on the strength and microstructure of concrete

Scientific Reports
The discharge of lead-contaminated effluents from industrial activities such as smelting, refining, and petrochemical operations poses a critical environmental challenge by polluting surface and groundwater resources. Among mitigation strategies, the use
Sedigheh Ghasemi, Peyman Homami, Jafar Keyvani Ghamsari   +2 more
doaj   +1 more source

Factors of the effectiveness of competitive activity of arm wrestlers aged 14-15 years at the stage of preliminary basic training

Слобожанський науково-спортивний вісник
Background and Study Aim. Considering that there are no studies aimed at identifying the components of physical and functional fitness in arm wrestling at the stage of preliminary basic training, and it is not advisable to transfer training of adult ...
Dmytro Bezkorovainyi, Artur Oderov, Kravchenko Anton, Leonid Plotnytskyi, Liudovyk Tetiana, Volodymyr Ozharevskyi   +5 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

ANALYSIS LAYER MODEL OF POLYMER COMPOSITE DESIGN UNDER MULTIFACTOR LOADING

Advanced Engineering Research, 2011
A mathematical model is offered for the analysis of complex stress-strain state of the layer load-carrying structures of the aircraft planes. It is presented as sets of the equations of the constraining relations of load parameters, voltages and ...
Oleg G. Osyaev, Yury A. Taturin, Alexey M. Kostin, Artur V. Zhukov   +3 more
doaj