Results 31 to 40 of about 5,368 (195)

Serial MultiView: An Efficient Approach to Mitigating Atmospheric Spatial-structure Errors for Very-long-baseline-interferometry Astrometry

open access: yesThe Astronomical Journal
Atmospheric propagation errors are a main constraint on the accuracy of very-long-baseline-interferometry astrometry. For relative astrometry, differential techniques can mitigate these errors, but their effectiveness diminishes with decreasing elevation
Jingdong Zhang   +6 more
doaj   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

open access: yesAdvanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang   +19 more
wiley   +1 more source

First Very Long Baseline Interferometry Detections at 870 μm

open access: yesThe Astronomical Journal
The first very long baseline interferometry (VLBI) detections at 870 μ m wavelength (345 GHz frequency) are reported, achieving the highest diffraction-limited angular resolution yet obtained from the surface of the Earth and the highest-frequency ...
Alexander W. Raymond   +278 more
doaj   +1 more source

Theory of optical long-baseline interferometry on polarized sources

open access: yesAstronomy & Astrophysics
The effects of the polarization characteristics of beam trains in optical long-baseline interferometers are well known and have led to difficulties in measuring the spatial coherence of astronomical sources in the past.
Perrin G.
doaj   +1 more source

Microfluidic Gratings for X‐Ray Phase Contrast Imaging

open access: yesAdvanced Science, EarlyView.
This work establishes a new protocol for the fabrication of X‐ray gratings that exploits the advantages of microfluidics and enables a more inexpensive, faster, and scalable production process. These X‐ray devices are fundamental for implementing X‐ray phase contrast imaging (XPCI) in laboratory and clinical settings, yet their costly and complex ...
Alessandro Rossi   +10 more
wiley   +1 more source

Wide-spectrum optical synthetic aperture imaging via spatial intensity interferometry

open access: yesOpto-Electronic Advances, 2023
High resolution imaging is achieved using increasingly larger apertures and successively shorter wavelengths. Optical aperture synthesis is an important high-resolution imaging technology used in astronomy.
Chunyan Chu   +6 more
doaj   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

open access: yesAdvanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li   +19 more
wiley   +1 more source

Measuring Black Hole Light Echoes with Very Long Baseline Interferometry

open access: yesThe Astrophysical Journal Letters
Light passing near a black hole can follow multiple paths from an emission source to an observer due to strong gravitational lensing. Photons following different paths take different amounts of time to reach the observer, which produces an echo signature
George N. Wong   +3 more
doaj   +1 more source

A bacterial protein inhibitor of dUTPase disrupts zebrafish embryogenesis through a conserved active-site mechanism. [PDF]

open access: yesProtein Sci
Abstract Deoxyuridine triphosphatase (dUTPase) is essential for DNA replication fidelity and embryonic development in metazoa, yet whether a protein inhibitor can acutely disrupt dUTPase function in a living vertebrate has not been tested. The Staphylococcus aureus Stl protein inhibits diverse dUTPases in vitro, but its efficacy in a eukaryotic ...
Perey-Simon V   +7 more
europepmc   +2 more sources

Nonlinear Ion‐Specific Control of Underwater Adhesion by Bottlebrush Polymer Interfaces

open access: yesAdvanced Science, EarlyView.
The efficiency of underwater adhesion is modulated by ion‐specific effects. Strongly hydrated Na+ remains separated from the mica surface by its hydration shell, preserving access to binding sites, whereas weakly hydrated K+ can partially dehydrate and occupy ditrigonal cavities.
Chang‐Sheng Wang   +10 more
wiley   +1 more source

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