Results 31 to 40 of about 5,368 (195)
AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor
Advanced Science, EarlyView.We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen +19 morewiley +1 more sourceFirst Very Long Baseline Interferometry Detections at 870 μm
The Astronomical JournalThe first very long baseline interferometry (VLBI) detections at 870 μ m wavelength (345 GHz frequency) are reported, achieving the highest diffraction-limited angular resolution yet obtained from the surface of the Earth and the highest-frequency ...Alexander W. Raymond, Sheperd S. Doeleman, Keiichi Asada, Lindy Blackburn, Geoffrey C. Bower, Michael Bremer, Dominique Broguiere, Ming-Tang Chen, Geoffrey B. Crew, Sven Dornbusch, Vincent L. Fish, Roberto García, Olivier Gentaz, Ciriaco Goddi, Chih-Chiang Han, Michael H. Hecht, Yau-De Huang, Michael Janssen, Garrett K. Keating, Jun Yi Koay, Thomas P. Krichbaum, Wen-Ping Lo, Satoki Matsushita, Lynn D. Matthews, James M. Moran, Timothy J. Norton, Nimesh Patel, Dominic W. Pesce, Venkatessh Ramakrishnan, Helge Rottmann, Alan L. Roy, Salvador Sánchez, Remo P. J. Tilanus, Michael Titus, Pablo Torne, Jan Wagner, Jonathan Weintroub, Maciek Wielgus, André Young, Kazunori Akiyama, Ezequiel Albentosa-Ruíz, Antxon Alberdi, Walter Alef, Juan Carlos Algaba, Richard Anantua, Rebecca Azulay, Uwe Bach, Anne-Kathrin Baczko, David Ball, Mislav Balokovic, Bidisha Bandyopadhyay, John Barrett, Michi Bauböck, Bradford A. Benson, Dan Bintley, Raymond Blundell, Katherine L. Bouman, Hope Boyce, Roger Brissenden, Silke Britzen, Avery E. Broderick, Thomas Bronzwaer, Sandra Bustamante, John E. Carlstrom, Andrew Chael, Chi-kwan Chan, Dominic O. Chang, Koushik Chatterjee, Shami Chatterjee, Yongjun Chen, Xiaopeng Cheng, Ilje Cho, Pierre Christian, Nicholas S. Conroy, John E. Conway, Thomas M. Crawford, Alejandro Cruz-Osorio, Yuzhu Cui, Rohan Dahale, Jordy Davelaar, Mariafelicia De Laurentis, Roger Deane, Jessica Dempsey, Gregory Desvignes, Jason Dexter, Vedant Dhruv, Indu K. Dihingia, Sergio A. Dzib, Ralph P. Eatough, Razieh Emami, Heino Falcke, Joseph Farah, Edward Fomalont, Anne-Laure Fontana, H. Alyson Ford, Marianna Foschi, Raquel Fraga-Encinas, William T. Freeman, Per Friberg, Christian M. Fromm, Antonio Fuentes, Peter Galison, Charles F. Gammie, Boris Georgiev, Roman Gold, Arturo I. Gómez-Ruiz, José L. Gómez, Minfeng Gu, Mark Gurwell, Kazuhiro Hada, Daryl Haggard, Ronald Hesper, Dirk Heumann, Luis C. Ho, Paul Ho, Mareki Honma, Chih-Wei L. Huang, Lei Huang, David H. Hughes, Shiro Ikeda, C. M. Violette Impellizzeri, Makoto Inoue, Sara Issaoun, David J. James, Buell T. Jannuzi, Britton Jeter, Wu Jiang, Alejandra Jiménez-Rosales, Michael D. Johnson, Svetlana Jorstad, Adam C. Jones, Abhishek V. Joshi, Taehyun Jung, Ramesh Karuppusamy, Tomohisa Kawashima, Mark Kettenis, Dong-Jin Kim, Jae-Young Kim, Jongsoo Kim, Junhan Kim, Motoki Kino, Prashant Kocherlakota, Yutaro Kofuji, Patrick M. Koch, Shoko Koyama, Carsten Kramer, Joana A. Kramer, Michael Kramer, Derek Kubo, Cheng-Yu Kuo, Noemi La Bella, Sang-Sung Lee, Aviad Levis, Zhiyuan Li, Rocco Lico, Greg Lindahl, Michael Lindqvist, Mikhail Lisakov, Jun Liu, Kuo Liu, Elisabetta Liuzzo, Andrei P. Lobanov, Laurent Loinard, Colin J. Lonsdale, Amy E. Lowitz, Ru-Sen Lu, Nicholas R. MacDonald, Sylvain Mahieu, Doris Maier, Jirong Mao, Nicola Marchili, Sera Markoff, Daniel P. Marrone, Alan P. Marscher, Iván Martí-Vidal, Lia Medeiros, Karl M. Menten, Izumi Mizuno, Yosuke Mizuno, Joshua Montgomery, Kotaro Moriyama, Monika Moscibrodzka, Wanga Mulaudzi, Cornelia Müller, Hendrik Müller, Alejandro Mus, Gibwa Musoke, Ioannis Myserlis, Hiroshi Nagai, Neil M. Nagar, Masanori Nakamura, Gopal Narayanan, Iniyan Natarajan, Antonios Nathanail, Santiago Navarro Fuentes, Joey Neilsen, Chunchong Ni, Michael A. Nowak, Junghwan Oh, Hiroki Okino, Héctor Raúl Olivares Sánchez, Tomoaki Oyama, Feryal Özel, Daniel C. M. Palumbo, Georgios Filippos Paraschos, Jongho Park, Harriet Parsons, Ue-Li Pen, Vincent Piétu, Aleksandar PopStefanija, Oliver Porth, Ben Prather, Giacomo Principe, Dimitrios Psaltis, Hung-Yi Pu, Philippe A. Raffin, Ramprasad Rao, Mark G. Rawlings, Angelo Ricarte, Bart Ripperda, Freek Roelofs, Cristina Romero-Cañizales, Eduardo Ros, Arash Roshanineshat, Ignacio Ruiz, Chet Ruszczyk, Kazi L. J. Rygl, David Sánchez-Argüelles, Miguel Sánchez-Portal, Mahito Sasada, Kaushik Satapathy, Tuomas Savolainen, F. Peter Schloerb, Jonathan Schonfeld, Karl-Friedrich Schuster, Lijing Shao, Zhiqiang Shen, Des Small, Bong Won Sohn, Jason SooHoo, León David Sosapanta Salas, Kamal Souccar, Ranjani Srinivasan, Joshua S. Stanway, He Sun, Fumie Tazaki, Alexandra J. Tetarenko, Paul Tiede, Kenji Toma, Teresa Toscano, Efthalia Traianou, Tyler Trent, Sascha Trippe, Matthew Turk, Ilse van Bemmel, Huib Jan van Langevelde, Daniel R. van Rossum, Jesse Vos, Derek Ward-Thompson, John Wardle, Jasmin E. Washington, Robert Wharton, Kaj Wiik, Gunther Witzel, Michael F. Wondrak, George N. Wong, Qingwen Wu, Nitika Yadlapalli, Paul Yamaguchi, Aristomenis Yfantis, Doosoo Yoon, Ziri Younsi, Wei Yu, Feng Yuan, Ye-Fei Yuan, J. Anton Zensus, Shuo Zhang, Guang-Yao Zhao, Shan-Shan Zhao +278 moredoaj +1 more sourceMicrofluidic Gratings for X‐Ray Phase Contrast Imaging
Advanced Science, EarlyView.This work establishes a new protocol for the fabrication of X‐ray gratings that exploits the advantages of microfluidics and enables a more inexpensive, faster, and scalable production process. These X‐ray devices are fundamental for implementing X‐ray phase contrast imaging (XPCI) in laboratory and clinical settings, yet their costly and complex ...Alessandro Rossi, Antonio Ferraro, Francesco Coccimiglio, Tiziana Ritacco, Alberto Astolfo, Michele Giocondo, Vincenzo Formoso, Raffaele Giuseppe Agostino, Francesco Iacoviello, Ioannis Papakonstantinou, Alessandro Olivo +10 morewiley +1 more sourceA Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi
Advanced Science, EarlyView.[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li +19 morewiley +1 more sourceNonlinear Ion‐Specific Control of Underwater Adhesion by Bottlebrush Polymer Interfaces
Advanced Science, EarlyView.The efficiency of underwater adhesion is modulated by ion‐specific effects. Strongly hydrated Na+ remains separated from the mica surface by its hydration shell, preserving access to binding sites, whereas weakly hydrated K+ can partially dehydrate and occupy ditrigonal cavities.Chang‐Sheng Wang, Hui Guo, Hu Zhang, Duy Anh Pham, Nahid Hassanpour, Wojciech Raj, Qiang Peng, Justine Saber, Tzu‐Hsuan Huang, Florina G. Halmac, Xavier Banquy +10 morewiley +1 more source