Results 41 to 50 of about 4,978 (186)

Measuring Black Hole Light Echoes with Very Long Baseline Interferometry

The Astrophysical Journal Letters
Light passing near a black hole can follow multiple paths from an emission source to an observer due to strong gravitational lensing. Photons following different paths take different amounts of time to reach the observer, which produces an echo signature
George N. Wong, Lia Medeiros, Alejandro Cárdenas-Avendaño, James M. Stone   +3 more
doaj   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Imaging “Pinwheel” nebulae with optical long-baseline interferometry [PDF]

Proceedings of the International Astronomical Union, 2010
AbstractDusty Wolf-Rayet stars are few but remarkable in terms of dust production rates (up to Ṁ = 10−6 M⊙/yr). Infrared excesses associated to mass-loss are found in the sub-types WC8 and WC9. Few WC9d stars are hosting a “pinwheel” nebula, indirect evidence of a companion star around the primary. While few other WC9d stars have a dust shell which has
Millour, Florentin, Driebe, Thomas, Groh, José, Chesneau, Olivier, Weigelt, Gerd, Liermann, Adriane, Meilland, Anthony   +6 more
openaire   +3 more sources

Demonstrating Photon Ring Existence with Single-baseline Polarimetry

The Astrophysical Journal Letters, 2023
Images of supermassive black hole accretion flows contain features of both curved spacetime and plasma structure. Inferring properties of the spacetime from images requires modeling the plasma properties, and vice versa.
Daniel C. M. Palumbo, George N. Wong, Andrew Chael, Michael D. Johnson   +3 more
doaj   +1 more source

Exceptional Antimodes in Multi‐Drive Cavity Magnonics

Advanced Electronic Materials, EarlyView.
Driven‐dissipative cavity‐magnonics provides a flexible platform for engineering non‐Hermitian physics such as exceptional points. Here, using a four‐port, three‐mode system with controllable microwave interference, antimodes and coherent perfect extinction (CPE) are realized, enabling active tuning to antimode exceptional points.
Mawgan A. Smith, Ryan D. McKenzie, Alban Joseph, Robert L. Stamps, Rair Macêdo   +4 more
wiley   +1 more source

Stability of PEA2PbBr4 Thin‐Film Photodetectors under Thermal and Moisture Stress

Advanced Electronic Materials, EarlyView.
This study investigates the environmental durability of 2D perovskite photodetectors under extreme heat and humidity. While pristine films degrade in harsh environmental conditions, adding a halogen‐bonding agent significantly improves stability. This passivated device maintains stable performance in conditions mimicking space and solar applications ...
Sara Cepić, Andrea Ciavatti, Enrico Gianfranco Campari, Beatrice Fraboni   +3 more
wiley   +1 more source

The First LWA Swarm Calibrator Survey

The Astrophysical Journal
The LWA Swarm is an aperture synthesis telescope consisting of interconnected Long Wavelength Array (LWA) stations autonomously making joint observations.
C. A. Taylor, G. B. Taylor, J. Dowell, S. Pezzaioli   +3 more
doaj   +1 more source

The ORCA‐TWIN qCMOS Experiment I. Science Case and Commissioning at Calar Alto Observatory

Astronomische Nachrichten, EarlyView.
ABSTRACT We describe a pilot study to explore a new generation of fast and low noise CMOS image sensors for time domain astronomy, using two remote telescopes with a baseline of 1635 km. The experiment involves direct imaging with novel qCMOS image sensor technology that combines fast readout with sub‐electron readout noise.
Martin M. Roth, Paško Roje, Stella Vješnica, Stefan Cikota, Alex J. Brown, Mike Kretlow, Marco Azzaro, Santiago Reinhart, Jesús Aceituno, Harry Dawson, Carsten Denker, Torsten Enßlin, Stephan Geier, Thomas Granzer, Thomas Kupfer, Gianluca Li Causi, Samaya Nissanke, José Luis Ortiz, Fernando Pedichini, Katja Poppenhäger, Axel Schwope   +20 more
wiley   +1 more source