Results 191 to 200 of about 9,101,712 (212)

Long interspersed nucleotide element‐1 hypomethylation in folate‐deficient mouse embryonic stem cells

Journal of Cellular Biochemistry, 2013
AbstractFolate is thought to contribute to health and development by methylation regulation. Long interspersed nucleotide element‐1 (LINE‐1), which is regulated by methylation modification, plays an important role in sculpting the structure and function of genomes.
Shaoyan, Chang, Li, Wang, Yunqian, Guan, Shaofang, Shangguan, Qingan, Du, Yang, Wang, Ting, Zhang, Yu, Zhang   +7 more
exaly   +3 more sources

Long Interspersed Nucleotide Element 1 Hypomethylation Is Associated With Poor Prognosis of Lung Adenocarcinoma

Annals of Thoracic Surgery, 2013
Genome-wide DNA hypomethylation is known to play important roles in genomic instability and carcinogenesis. Methylation in long interspersed nucleotide element 1 (LINE-1) is a good indicator of the global DNA methylation level within a cell. The aim of this study was to evaluate prognostic significance of LINE-1 hypomethylation in lung adenocarcinoma.A
Takeshi Mori, Yoshifumi Baba
exaly   +3 more sources

Length distribution of long interspersed nucleotide elements (LINEs) and processed pseudogenes of human endogenous retroviruses: implications for retrotransposition and pseudogene detection

Gene, 2002
Deciphering the human genome includes reliable identification and structural characterization of individual retrotransposon elements. The most active group of autonomous transposable elements, the long interspersed nuclear elements (LINE), transpose themselves as well as other RNAs, including those of human endogenous retroviruses (HERV).
Jiří Hejnar, Paces J, Adam Pavlı́ček   +2 more
exaly   +3 more sources

Assessing the Expression of Long INterspersed Elements (LINEs) via Long-Read Sequencing in Diverse Human Tissues and Cell Lines

Genes, 2023
Transposable elements, such as Long INterspersed Elements (LINEs), are DNA sequences that can replicate within genomes. LINEs replicate using an RNA intermediate followed by reverse transcription and are typically a few kilobases in length. LINE activity
Jinchuan Xing, Karleena Rybacki
exaly   +2 more sources

Long interspersed nucleotide element‐1 hypomethylation in canine malignant mucosal melanoma

Veterinary and Comparative Oncology, 2020
AbstractCanine malignant melanoma is a common cancer with a high mortality rate and is a clinically important disease. DNA methylation has been considered to be a potential tumorigenic mechanism through aberrant DNA methylation at promoter region which represses gene transcription.
Teita Ishizaki, Jumpei Yamazaki, Shinji Meagawa, Nozomu Yokoyama, Keisuke Aoshima, Mitsuyoshi Takiguchi, Takashi Kimura   +6 more
openaire   +2 more sources

Long Interspersed Nucleotide Element

, 2008
openaire   +2 more sources

Tumor Long-interspersed Nucleotide Element-1 Methylation Level and Immune Response to Esophageal Cancer

Annals of Surgery, 2019
Objective: To examine the relationship between tumor long-interspersed nucleotide element-1 (LINE-1) methylation level and immune response to esophageal cancer. Background: Evidence points to a correlation between the abundance of immune cells and a favorable prognosis in esophageal
Keisuke, Kosumi, Yoshifumi, Baba, Kazuo, Okadome, Taisuke, Yagi, Yuki, Kiyozumi, Naoya, Yoshida, Masayuki, Watanabe, Hideo, Baba   +7 more
openaire   +2 more sources

PCR and Magnetic Bead-Mediated Target Capture for the Isolation of Short Interspersed Nucleotide Elements in Fishes

International Journal of Molecular Sciences, 2012
Short interspersed nucleotide elements (SINEs), a type of retrotransposon, are widely distributed in various genomes with multiple copies arranged in different orientations, and cause changes to genes and genomes during evolutionary history.
Jinquan Yang, Wenqiao Tang, Hongyi Guo, Dong Liu, Guoli Zhu   +4 more
exaly   +2 more sources

Hypomethylation of long interspersed nucleotide element‐1 in peripheral mononuclear cells of juvenile systemic lupus erythematosus patients in China

International Journal of Rheumatic Diseases, 2013
AbstractAimMethylation abnormalities in T lymphocytes have been reported to correlate with systemic lupus erythematosus (SLE). Previous studies identified hypomethylation in the promoter of several genes linked to SLE. Long interspersed nucleotide element‐1 (LINE‐1) constitutes 17–25% of the human genome, and LINE‐1 hypomethylation has been reported in
Xiaolan, Huang, Gaixiu, Su, Zhen, Wang, Shaofang, Shangguan, Xiaodai, Cui, Jia, Zhu, Min, Kang, Shengnan, Li, Ting, Zhang, Fengqi, Wu, Li, Wang   +10 more
openaire   +2 more sources

Tissue-Specific Methylation of Long Interspersed Nucleotide Element-1 of Homo Sapiens (L1Hs) During Human Embryogenesis and Roles in Neural Tube Defects

Current Molecular Medicine, 2015
Epigenetic regulation of long interspersed nucleotide element-1 (LINE-1) retrotransposition events plays crucial roles during early development. Previously we showed that LINE-1 hypomethylation in neuronal tissues is associated with pathogenesis of neural tube defect (NTD).
L, Wang, S, Chang, J, Guan, S, Shangguan, X, Lu, Z, Wang, L, Wu, J, Zou, H, Zhao, Y, Bao, Z, Qiu, B, Niu, T, Zhang   +12 more
openaire   +2 more sources