Results 101 to 110 of about 457,250 (297)

Cascade transcription of mRNA-type long non-coding RNAs (mlonRNAs) and local chromatin remodeling [PDF]

, 2009
Kouji Hirota, Kunihiro Ohta
openalex   +1 more source

New Insights into Long Non-Coding RNA MALAT1 in Cancer and Metastasis

Cancers, 2019
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is one of the most abundant, long non-coding RNAs (lncRNAs) in normal tissues. This lncRNA is highly conserved among mammalian species, and based on in vitro results, has been reported to ...
Yutong Sun, Li Ma
semanticscholar   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis [PDF]

, 2010
Rajnish A. Gupta, Nilay Shah, Ke Wang, Jeewon Kim, Hugo M. Horlings, David J. Wong, Miao-Chih Tsai, Tiffany Hung, Pedram Argani, John L. Rinn, Yulei Wang, Pius Brzoska, Benjamin Kong, Rui Li, Robert B. West, Marc J. van de Vijver, Saraswati Sukumar, Howard Y. Chang   +17 more
openalex   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis

Journal of Hematology & Oncology, 2019
BackgroundLong non-coding RNAs (lncRNAs) have been associated with non-small cell lung cancer (NSCLC), but the underlying molecular mechanisms of their specific roles in mediating aerobic glycolysis have been poorly explored.MethodsNext-generation RNA ...
Qian Hua, Mingming Jin, Baoming Mi, Fei Xu, Tian Li, Li Zhao, Jianju Liu, Gang Huang   +7 more
semanticscholar   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

HDAC3 inhibition mitigates acute kidney injury by alleviating RIPK1-mediated programmed necrosis

Frontiers in Pharmacology
Acute kidney injury (AKI) refers to clinical syndromes culminating in rapidly reduced renal function associated with inflammation and the demise of renal tubular epithelial cells.
Manman Xie, Manman Xie, Rui Hou, Runrun Shan, Xinyu Cheng, Pengcheng Wu, Xiufeng Luo, Yangyang Wei, Li Gao, Xiaoying Liu, Xiaoying Liu, Qi Chen   +11 more
doaj   +1 more source

Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse [PDF]

, 2010
Björn Reinius, Chengxi Shi, Liu Hengshuo, Kuljeet Singh Sandhu, Katarzyna J. Radomska, Glenn D. Rosen, Lu Lu, Klas Kullander, Robert W. Williams, Elena Jazin   +9 more
openalex   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source