Results 101 to 110 of about 718,965 (394)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Long non-coding RNA MSTO2P promotes the proliferation and colony formation in gastric cancer by indirectly regulating miR-335 expression

Tumor Biology, 2017
Long non-coding RNAs are emerging as new players in gene regulation, but whether long non-coding RNAs influence the expression of microRNA is unclear.
Han Li, Hua Zhu, Yanbing Zhou, Haibo Wang, Zhaojian Niu, Yi Shen, Liang Lv   +6 more
doaj   +1 more source

Expression of the Long Non-Coding RNA HOTAIR Correlates with Disease Progression in Bladder Cancer and Is Contained in Bladder Cancer Patient Urinary Exosomes

PLoS ONE, 2016
Exosomes are 30-150nM membrane-bound secreted vesicles that are readily isolated from biological fluids such as urine (UEs). Exosomes contain proteins, micro RNA (miRNA), messenger RNA (mRNA), and long non-coding RNA (lncRNA) from their cells of origin ...
Claudia Berrondo, J. Flax, V. Kucherov, Aisha Siebert, T. Osinski, Alex F. Rosenberg, Christopher Fucile, Samuel Richheimer, C. Beckham   +8 more
semanticscholar   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers [PDF]

, 2012
Background: Molecular characterization of tumors has been critical for identifying important genes in cancer biology and for improving tumor classification and diagnosis.
Beck, Andrew H, Brunner, Alayne L, Chang, Howard Y, Edris, Badreddin, Flynn, Ryan A, Foley, Joseph W, Giacomini, Craig P, Gilks, Thea, Guo, Xiangqian, Li, Rui, Montgomery, Kelli, Pollack, Jonathan R, Sweeney, Robert T, Tibshirani, Robert, van de Rijn, Matt, Varma, Sushama, West, Robert B, Witten, Daniela M, Zhu, Shirley X   +18 more
core   +1 more source

Long Non-coding RNA

, 2015
Rapid development in genome-wide transcriptional analyses has led to the discovery of a large number of non-coding transcripts, also called long non-coding RNA (lncRNA). LncRNAs harbor biological activities including regulation of protein-coding gene expression at epigenetic, transcriptional and post-transcriptional levels.
openaire   +2 more sources

Long non-coding RNAs in ovarian cancer [PDF]

Journal of Experimental & Clinical Cancer Research, 2018
Long non-coding RNAs (lncRNAs) refer to functional cellular RNAs molecules longer than 200 nucleotides in length. Unlike microRNAs, which have been widely studied, little is known about the enigmatic role of lncRNAs. However, lncRNAs have motivated extensively attention in the past few years and are emerging as potentially important regulators in ...
Jun Li, Bing Wei, Lei Zhan
openaire   +4 more sources

Diagnostic value of serum COMP and ADAMTS7 for intervertebral disc degeneration

European Journal of Medical Research
Objective Intervertebral disc degeneration (IVDD) is a major cause of morbidity and disability. Our study aimed to investigate the potential of cartilage oligomeric matrix protein (COMP) and ADAMTS7 (A disintegrin and metalloproteinases with ...
Jing-Yu Ding, Xu Yan, Ren-Jie Zhang, Hua-Qing Zhang, Liang Kang, Chong-Yu Jia, Rick F. Thorne, Xiao-Ying Liu , Cai-Liang Shen   +8 more
doaj   +1 more source

MiRNA-related metastasis in oral cancer: moving and shaking

Cancer Cell International, 2023
Across the world, oral cancer is a prevalent tumor. Over the years, both its mortality and incidence have grown. Oral cancer metastasis is a complex process involving cell invasion, migration, proliferation, and egress from cancer tissue either by ...
Meghdad Eslami, Saba Khazeni, Xaniar Mohammadi Khanaghah, Mohammad Hossein Asadi, Mohamad Amin Ansari, Javad Hayati Garjan, Mohammad Hassan Lotfalizadeh, Mobina Bayat, Mohammad Taghizadieh, Seyed Pouya Taghavi, Michael R Hamblin, Javid Sadri Nahand   +11 more
doaj   +1 more source

Long non-coding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and upregulate ITGB3.

Cancer Research, 2019
Long non-coding RNAs (lncRNAs) play important roles in the tumorigenesis and progression of cancers. However, the clinical significance of lncRNAs and their regulatory mechanisms in nasopharyngeal carcinogenesis (NPC) are largely unknown.
Zi-Qi Zheng, Zhi-Xuan Li, G. Zhou, Li Lin, Lulu Zhang, J. Lv, Xiao-Dan Huang, Rui-Qi Liu, Fo-Ping Chen, Xiao-Jun He, J. Kou, J. Zhang, Xin Wen, Yingqin Li, Jun Ma, Na Liu, Ying Sun   +16 more
semanticscholar   +1 more source