Results 101 to 110 of about 728,039 (351)

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

A novel long non-coding RNA XLOC_004787, is associated with migration and promotes cancer cell proliferation by downregulating mir-203a-3p in gastric cancer [PDF]

, 2023
Renjie Miao, Zhendong Yao, Bingheng Hu, Tao Jin, Dong‐Lai Zhu, Yun‐Bo Shi, Yuhua Gong, Shihe Shao, Chen Shao   +8 more
openalex   +1 more source

The complex transcriptional landscape of the anucleate human platelet. [PDF]

, 2013
BACKGROUND: Human blood platelets are essential to maintaining normal hemostasis, and platelet dysfunction often causes bleeding or thrombosis. Estimates of genome-wide platelet RNA expression using microarrays have provided insights to the platelet ...
Bray, Paul F, Chen, Huang-Wen, Delgrosso, Kathleen, Edelstein, Leonard, Ertel, Adam, Fortina, Paolo, Jing, Yi, Kupper, Joan, Loher, Phillipe, Londin, Eric R, McKenzie, Steven E, Nagalla, Srikanth, Rigoutsos, Isidore   +12 more
core   +1 more source

The H19 Long non-coding RNA in cancer initiation, progression and metastasis – a proposed unifying theory

Molecular Cancer, 2015
The imprinted oncofetal long non-coding RNA (lncRNA) H19 is expressed in the embryo, down-regulated at birth and then reappears in tumors. Its role in tumor initiation and progression has long been a subject of controversy, although accumulating data ...
E. Raveh, I. Matouk, Michal Gilon, A. Hochberg   +3 more
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Long non-coding RNA LINC02613 is a prognostic biomarker for breast cancer and correlates with the cell cycle and immune infiltration based on TCGA data [PDF]

, 2022
Mengyao Cui, Yanbiao Liu, Lei Cui
openalex   +1 more source

Emerging roles of long non‐coding RNA in cancer

Cancer Science, 2018
Since comprehensive analysis of the mammalian genome revealed that the majority of genomic products are transcribed in long non‐coding RNA (lncRNA), increasing attention has been paid to these transcripts.
Anna Sanchez Calle, Yumi Kawamura, Yusuke Yamamoto, F. Takeshita, T. Ochiya   +4 more
semanticscholar   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Non-coding RNAs in primary liver cancer

Frontiers in Medicine, 2015
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with poor prognosis and limited therapeutic options. Over the past few years, many studies have evaluated the role of non-coding RNAs (ncRNAs) in hepatocarcinogenesis and tumour ...
Michele eGhidini, Michele eGhidini, CHIARA eBRACONI, CHIARA eBRACONI   +3 more
doaj   +1 more source

Non-coding RNAs in Transcriptional Regulation [PDF]

, 2015
Transcriptional gene silencing guided by small RNAs is a process conserved from protozoa to mammals. Small RNAs loaded into Argonaute family proteins direct repressive histone modifications or DNA cytosine methylation to homologous regions of the genome.
Aravin, Alexei A., Chen, Yung-Chia Ariel
core   +1 more source