Results 111 to 120 of about 16,781,272 (315)
Approaches to Identify and Characterise the Post-Transcriptional Roles of lncRNAs in Cancer
, 2021 It is becoming increasingly evident that the non-coding genome and transcriptome exert great influence over their coding counterparts through complex molecular interactions.
Li, Yinghui +9 more
core +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
More than the SRY: The Non-Coding Landscape of the Y Chromosome and Its Importance in Human Disease
Historically, the Y chromosome has presented challenges to classical methodology and philosophy of understanding the differences between males and females. A genetic unsolved puzzle, the Y chromosome was the last chromosome to be fully sequenced.
Ivan Martinez +3 more
core +1 more source
, 2017 Background: Recent advances in sequencing technology have opened a new era in RNA studies. Novel types of RNAs such as long non-coding RNAs (lncRNAs) have been discovered by transcriptomic sequencing and some lncRNAs have been found to play essential ...
Chen, Mei-Ju May;Chen, Li-Kai;Lai, Yu-Shing;Lin, Yu-Yu;Wu, Dung-Chi;Tung, Yi-An;Liu, Kwei-Yan;Shih, Hsueh-Tzu;Chen, Yi-Jyun;Lin, Yan-Liang;Ma, Li-Ting;Huang, Jian-Long;Wu, Po-Chun;Hong, Ming-Yi;Chu, Fang-Hua;Wu, June-Tai;Li, Wen-Hsiung;Chen, Chien-Yu +1 more
core +1 more source
Non-Syndromic Intellectual Disability and Its Pathways: A Long Noncoding RNA Perspective
, 2021 Non-syndromic intellectual disability (NS-ID or idiopathic) is a complex neurodevelopmental disorder that represents a global health issue. Although many efforts have been made to characterize it and distinguish it from syndromic intellectual disability (
Jessica O. Santis +8 more
core +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The Role of Long Non-Coding RNAs in Human Endoderm Differentiation
The human genome sequencing revealed a vast complexity of transcripts, with over 80% of the genome being transcribed into non-coding RNAs. In particular, long non-coding RNAs (lncRNAs) have emerged as critical regulators of various cellular processes ...
Bruno Dallagiovanna +1 more
core +1 more source
Noncoder : a web interface for exon array-based detection of long non-coding RNAs [PDF]
, 2012 Due to recent technical developments, a high number of long non-coding RNAs (lncRNAs) have been discovered in mammals. Although it has been shown that lncRNAs are regulated differently among tissues and disease statuses, functions of these transcripts ...
Braun, Thomas +3 more
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Long Non-Coding RNA TUG1 Expression Is Associated with Different Subtypes in Human Breast Cancer
, 2017 Taurine upregulated 1 gene (TUG1) is a long non-coding RNA associated with several types of cancer. Recently, differential expression of TUG1 was found in cancerous breast tissues and associated with breast cancer malignancy features.
Carolina Mathias +9 more
core +1 more source