Results 121 to 130 of about 728,039 (351)

Immune-related long non-coding RNAs can serve as prognostic biomarkers for clear cell renal cell carcinoma [PDF]

, 2021
Cheng Shan Li, Zhang Ze Lu, Da Fang, Wei Zhou, Jie Wei   +4 more
openalex   +1 more source

MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches

Journal of Hematology & Oncology, 2018
The deeper understanding of non-coding RNAs has recently changed the dogma of molecular biology assuming protein-coding genes as unique functional biological effectors, while non-coding genes as junk material of doubtful significance. In the last decade,
N. Amodio, L. Raimondi, G. Juli, Maria Angelica Stamato, D. Caracciolo, P. Tagliaferri, P. Tassone   +6 more
semanticscholar   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Long non-coding RNA DSCAM-AS1 promotes pancreatic cancer progression via regulating the miR-136-5p/PBX3 axis [PDF]

, 2022
Xing Huang, Zihe Wang, Shengzhong Hou, Chao Yue, Zhenlu Li, Weiming Hu, Huimin Lu   +6 more
openalex   +1 more source

The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan

Nature, 2016
Neutrophils, eosinophils and ‘classical’ monocytes collectively account for about 70% of human blood leukocytes and are among the shortest-lived cells in the body.
Jonathan J Kotzin, Sean P. Spencer, S. McCright, Dinesh B. Uthaya Kumar, Magalie A. Collet, Walter K. Mowel, Ellen N. Elliott, A. Uyar, M. Makiya, Margaret C. Dunagin, Christian C. D. Harman, Anthony T. Virtue, Stella Zhu, Will Bailis, Judith Stein, C. Hughes, A. Raj, E. Wherry, L. Goff, A. Klion, J. Rinn, Adam Williams, R. A. Flavell, Jorge Henao-Mejia   +23 more
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia [PDF]

, 2021
Mattias Hofmans, Tim Lammens, Barbara Depreter, Ying Wu, Miriam Erlacher, Aurélie Caye, Hélène Cavé, Christian Flotho, Valérie de Haas, Charlotte M. Niemeyer, Jan Starý, Filip Van Nieuwerburgh, Dieter Deforce, Wouter Van Loocke, Pieter Van Vlierberghe, Jan Philippé, Barbara De Moerloose   +16 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Long Non-Coding RNA NBR2 Suppresses the Progression of Colorectal Cancer by Downregulating miR-19a to Regulate M2 Macrophage Polarization

, 2023
Xiaoting Yang, Ye Luo, Mengying Li, Zhan Jin, Gao Chen, Chunchun Gan   +5 more
openalex   +1 more source

An Overview of Long Non-Coding (lnc)RNAs in Neuroblastoma [PDF]

, 2021
Francesca Baldini, Matilde Calderoni, Laura Vergani, Paola Modesto, Tullio Florio, Aldo Pagano   +5 more
openalex   +1 more source