Results 131 to 140 of about 728,039 (351)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Image_3_Dissecting the Role of N6-Methylandenosine-Related Long Non-coding RNAs Signature in Prognosis and Immune Microenvironment of Breast Cancer.TIF

, 2021
Jinguo Zhang (2249806), Benjie Shan (5881088), Lin Lin (46073), Jie Dong (12143), Qingqing Sun (280493), Qiong Zhou (169101), Jian Chen (15340), Xinghua Han (3047892)   +7 more
openalex   +2 more sources

Regulatory Role of Long Non-Coding RNA “Maternally-Expressed Gene-3” in Diabetic Nephropathy through Targeting microRNA-21 and Transforming Growth Factor-Beta [PDF]

, 2022
Heba M. Elwi, Shimaa El-Din, Laila Rashed, Noha Adly Sadek, Engy Medhat   +4 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Additional file 7 of Genome-wide identification and characterization of long non-coding RNAs conferring resistance to Colletotrichum gloeosporioides in walnut (Juglans regia)

, 2021
Shan Feng, Hongcheng Fang, Xia Liu, Yuhui Dong, Qingpeng Wang, Ke Yang   +5 more
openalex   +1 more source

Correction for: Silencing of long non-coding RNA H19 downregulates CTCF to protect against atherosclerosis by upregulating PKD1 expression in ApoE knockout mice [PDF]

, 2021
Yongyao Yang, Feng Tang, Fang Wei, Long Yang, Chunyan Kuang, Hongming Zhang, Jiusheng Deng, Qiang Wu   +7 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Long non-coding RNA L13Rik promotes high glucose-induced mesangial cell injury by regulating miR-2861/CDKN1B axis [PDF]

, 2022
Linlin Sun, Miao Ding, Fuhua Chen, Dingyu Zhu, Xinmiao Xie   +4 more
openalex   +1 more source

Long non-coding RNA MALAT1 suppresses breast cancer metastasis

Nature Genetics, 2018
MALAT1 has previously been described as a metastasis-promoting long noncoding RNA (lncRNA). We show here, however, that targeted inactivation of the Malat1 gene in a transgenic mouse model of breast cancer, without altering the expression of its adjacent
Jongchan Kim, Hai-long Piao, Hai-long Piao, Beom-Jun Kim, Fan Yao, Zhenbo Han, Yumeng Wang, Zhenna Xiao, Ashley N. Siverly, Sarah E Lawhon, Baochau N. Ton, Hyemin Lee, Zhicheng Zhou, B. Gan, S. Nakagawa, M. Ellis, Han Liang, M. Hung, M. Hung, M. J. You, Yutong Sun, Li Ma   +21 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source