Results 131 to 140 of about 739,569 (400)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Non-coding RNAs in primary liver cancer

open access: yesFrontiers in Medicine, 2015
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with poor prognosis and limited therapeutic options. Over the past few years, many studies have evaluated the role of non-coding RNAs (ncRNAs) in hepatocarcinogenesis and tumour ...
Michele eGhidini   +3 more
doaj   +1 more source

Characterization of a Novel Long Non-coding RNA Involved in Thyroid Differentiation [PDF]

open access: yes, 2017
Thyroid is the endocrine gland that most frequently undergoes to congenital disorders or neoplastic transformation and despite its organogenesis is well characterized, molecular bases of early thyroid differentiation are still obscure. During last years,
Credendino, Sara Carmela
core   +1 more source

An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes

open access: yesFrontiers in Oncology, 2020
The small nucleolar RNA host genes (SNHGs) are a group of long non-coding RNAs, which are reported in many studies as being overexpressed in various cancers.
Alina-Andreea Zimta   +5 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Long non-coding RNA MALAT1 suppresses breast cancer metastasis

open access: yesNature Genetics, 2018
MALAT1 has previously been described as a metastasis-promoting long noncoding RNA (lncRNA). We show here, however, that targeted inactivation of the Malat1 gene in a transgenic mouse model of breast cancer, without altering the expression of its adjacent
Jongchan Kim   +21 more
semanticscholar   +1 more source

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