Results 161 to 170 of about 739,569 (400)

HDAC3 inhibition mitigates acute kidney injury by alleviating RIPK1-mediated programmed necrosis

Frontiers in Pharmacology
Acute kidney injury (AKI) refers to clinical syndromes culminating in rapidly reduced renal function associated with inflammation and the demise of renal tubular epithelial cells.
Manman Xie, Manman Xie, Rui Hou, Runrun Shan, Xinyu Cheng, Pengcheng Wu, Xiufeng Luo, Yangyang Wei, Li Gao, Xiaoying Liu, Xiaoying Liu, Qi Chen   +11 more
doaj   +1 more source

Long Non-coding RNA H19 Induces Cerebral Ischemia Reperfusion Injury via Activation of Autophagy

Aging and Disease, 2017
Long non-coding RNA H19 (lncRNA H19) was found to be upregulated by hypoxia, its expression and function have never been tested in cerebral ischemia and reperfusion (I/R) injury.
Jue Wang, Bin Cao, Dong-Sun Han, Miao Sun, Juan Feng   +4 more
semanticscholar   +1 more source

Regulatory Role of Long Non-Coding RNA “Maternally-Expressed Gene-3” in Diabetic Nephropathy through Targeting microRNA-21 and Transforming Growth Factor-Beta [PDF]

, 2022
Heba M. Elwi, Shimaa El-Din, Laila Rashed, Noha Adly Sadek, Engy Medhat   +4 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Long non-coding RNA: its evolutionary relics and biological implications in mammals: a review

Journal of Animal Science and Technology, 2018
The central dogma of gene expression propounds that DNA is transcribed to mRNA and finally gets translated into protein. Only 2–3% of the genomic DNA is transcribed to protein-coding mRNA.
J. Dhanoa, R. Sethi, Ramneek Verma, J. Arora, C. S. Mukhopadhyay   +4 more
semanticscholar   +1 more source

lncRNA_Mdeep: an alignment-free predictor for long non-coding RNAs identification by multimodal deep learning [PDF]

, 2019
Xiao-Nan Fan, Shao‐Wu Zhang, Song-Yao Zhang, Jinjie Ni   +3 more
openalex   +1 more source

318 The long non-coding RNA LINC00958 is overexpressed in psoriasis epidermis and induces keratinocyte proliferation [PDF]

, 2022
Lei Luo, L. Pasquali, A. Srivastava, A. Pivarcsi, E. Sonkoly   +4 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway

OncoTarget, 2016
Recently, the long non-coding RNA (lncRNA) NEAT1 has been identified as an oncogenic gene in multiple cancer types and elevated expression of NEAT1 was tightly linked to tumorigenesis and cancer progression.
Chengcao Sun, Shujun Li, Feng Zhang, Yongyong Xi, Liang Wang, Y. Bi, Dejia Li   +6 more
semanticscholar   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source