Results 171 to 180 of about 703,919 (374)

Long non-coding RNA MALAT1 suppresses breast cancer metastasis

Nature Genetics, 2018
MALAT1 has previously been described as a metastasis-promoting long noncoding RNA (lncRNA). We show here, however, that targeted inactivation of the Malat1 gene in a transgenic mouse model of breast cancer, without altering the expression of its adjacent
Jongchan Kim, Hai-long Piao, Hai-long Piao, Beom-Jun Kim, Fan Yao, Zhenbo Han, Yumeng Wang, Zhenna Xiao, Ashley N. Siverly, Sarah E Lawhon, Baochau N. Ton, Hyemin Lee, Zhicheng Zhou, B. Gan, S. Nakagawa, M. Ellis, Han Liang, M. Hung, M. Hung, M. J. You, Yutong Sun, Li Ma   +21 more
semanticscholar   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Prediction of plant lncRNA by ensemble machine learning classifiers

BMC Genomics, 2018
Background In plants, long non-protein coding RNAs are believed to have essential roles in development and stress responses. However, relative to advances on discerning biological roles for long non-protein coding RNAs in animal systems, this RNA class ...
Caitlin M. A. Simopoulos, Elizabeth A. Weretilnyk, G. Brian Golding   +2 more
doaj   +1 more source

Cascade transcription of mRNA-type long non-coding RNAs (mlonRNAs) and local chromatin remodeling [PDF]

, 2009
Kouji Hirota, Kunihiro Ohta
openalex   +1 more source

Long Non-coding RNA H19 Induces Cerebral Ischemia Reperfusion Injury via Activation of Autophagy

Aging and Disease, 2017
Long non-coding RNA H19 (lncRNA H19) was found to be upregulated by hypoxia, its expression and function have never been tested in cerebral ischemia and reperfusion (I/R) injury.
Jue Wang, Bin Cao, Dong-Sun Han, Miao Sun, Juan Feng   +4 more
semanticscholar   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis [PDF]

, 2010
Rajnish A. Gupta, Nilay Shah, Ke Wang, Jeewon Kim, Hugo M. Horlings, David J. Wong, Miao-Chih Tsai, Tiffany Hung, Pedram Argani, John L. Rinn, Yulei Wang, Pius Brzoska, Benjamin Kong, Rui Li, Robert B. West, Marc J. van de Vijver, Saraswati Sukumar, Howard Y. Chang   +17 more
openalex   +1 more source

New Insights into Long Non-Coding RNA MALAT1 in Cancer and Metastasis

Cancers, 2019
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is one of the most abundant, long non-coding RNAs (lncRNAs) in normal tissues. This lncRNA is highly conserved among mammalian species, and based on in vitro results, has been reported to ...
Yutong Sun, Li Ma
semanticscholar   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Influence of viral genes on the cell-to-cell spread of RNA silencing [PDF]

The turnip crinkle virus-based vector TCV–GFPDCP had been devised previously to study cell-to-cell and long-distance spread of virus-induced RNA silencing.
Hong, Yiguo, Ryabov, Eugene V., Zhang, Xuemei, Zhou, Yu   +3 more
core   +1 more source